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Tchem
IDI1
Isopentenyl-diphosphate Delta-isomerase 1

Protein Summary
Description
Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP). IDI1 encodes a peroxisomally-localized enzyme that catalyzes the interconversion of isopentenyl diphosphate (IPP) to its highly electrophilic isomer, dimethylallyl diphosphate (DMAPP), which are the substrates for the successive reaction that results in the synthesis of farnesyl diphosphate and, ultimately, cholesterol. It has been shown in peroxisomal deficiency diseases such as Zellweger syndrome and neonatal adrenoleukodystrophy that there is reduction in IPP isomerase activity. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000381344
  • ENSP00000370748
  • ENSG00000067064
  • ENST00000429642
  • ENSP00000401879

Symbol
  • IPP1
  • IPPI1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor perturbation
0.96
disease perturbation
0.95
kinase perturbation
0.88
transcription factor binding site profile
0.83
gene perturbation
0.76


Protein Classes
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 77.36   (req: < 5)
Gene RIFs: 5   (req: <= 3)
Antibodies: 149   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 77.36   (req: >= 5)
Gene RIFs: 5   (req: > 3)
Antibodies: 149   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 1
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
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GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
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GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Protein-Protein Interactions (92)
VWA8
Tdark
Novelty:  0.17546432
p_int:  0.858989007
p_ni:  0.141010993
Score:  0.455
Data Source:  BioPlex,STRINGDB
MVD
Tchem
Family:  Enzyme
Novelty:  0.0067581
Score:  0.997
Data Source:  STRINGDB
FDPS
Tclin
Family:  Enzyme
Novelty:  0.00164195
Score:  0.994
Data Source:  STRINGDB
SQLE
Tchem
Family:  Enzyme
Novelty:  0.0059338
Score:  0.989
Data Source:  STRINGDB
HMGCS1
Tchem
Family:  Enzyme
Novelty:  0.01089288
Score:  0.988
Data Source:  STRINGDB
GGPS1
Tchem
Family:  Enzyme
Novelty:  0.00292258
Score:  0.987
Data Source:  STRINGDB
MSMO1
Tbio
Family:  Enzyme
Novelty:  0.01263528
Score:  0.987
Data Source:  STRINGDB
FDFT1
Tchem
Family:  Enzyme
Novelty:  0.00225882
Score:  0.986
Data Source:  STRINGDB
HMGCR
Tclin
Family:  Enzyme
Novelty:  0.00046789
Score:  0.976
Data Source:  STRINGDB
CYP51A1
Tchem
Family:  Enzyme
Novelty:  0.00127373
Score:  0.975
Data Source:  STRINGDB
Pathways (41)
Activation of gene expression by SREBF (SREBP) (R-HSA-2426168)

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Find Similar Targets
Items per page:
1 – 5 of 6
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Activation of gene expression by SREBF (SREBP)
Reactome
Cholesterol biosynthesis
Reactome
Metabolism
Reactome
Metabolism of lipids
Reactome
Metabolism of steroids
Name
Explore in Pharos
Explore in Source
Activation of gene expression by SREBF (SREBP)
Cholesterol biosynthesis
Metabolism
Metabolism of lipids
Metabolism of steroids
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (12)
Find Similar Targets
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Electronic Annotation (IEA)
InterPro
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Disease Associations ()
No disease associations found
GWAS Traits (7)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
creatinine measurement
3
2
3
90.7
glomerular filtration rate
3
2
3
90.6
eosinophil count
2
2
2
84.6
eosinophil percentage of leukocytes
2
2
2
83.2
testosterone measurement
1
1
1
64.9
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
creatinine measurement
3
90.7
glomerular filtration rate
3
90.6
eosinophil count
2
84.6
eosinophil percentage of leukocytes
2
83.2
testosterone measurement
1
64.9
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
isopentenyl-diphosphate delta isomerase 1
VGNC:12346
104008078
Macaque
isopentenyl-diphosphate delta isomerase 1
710052
Mouse
MGI:2442264
319554
Rat
RGD:621835
89784
Cow
isopentenyl-diphosphate delta isomerase 1
514293
Species
Name
OMA
EggNOG
Inparanoid
Chimp
isopentenyl-diphosphate delta isomerase 1
Macaque
isopentenyl-diphosphate delta isomerase 1
Mouse
Rat
Cow
isopentenyl-diphosphate delta isomerase 1
Publication Statistics
PubMed Score 77.36
PubMed score by year
PubTator Score 11.04
PubTator score by year
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Related Publications
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0 of 0
PMID
Year
Title