Tbio C1D Nuclear nucleic acid-binding protein C1D

Protein Summary

Description

Plays a role in the recruitment of the RNA exosome complex to pre-rRNA to mediate the 3'-5' end processing of the 5.8S rRNA; this function may include MPHOSPH6. Can activate PRKDC not only in the presence of linear DNA but also in the presence of supercoiled DNA. Can induce apoptosis in a p53/TP53 dependent manner. May regulate the TRAX/TSN complex formation. Potentiates transcriptional repression by NR1D1 and THRB (By similarity). The protein encoded by this gene is a DNA binding and apoptosis-inducing protein and is localized in the nucleus. It is also a Rac3-interacting protein which acts as a corepressor for the thyroid hormone receptor. This protein is thought to regulate TRAX/Translin complex formation. Alternate splicing results in multiple transcript variants that encode the same protein. Multiple pseudogenes of this gene are found on chromosome 10.[provided by RefSeq, Jun 2010]

Uniprot Accession IDs

• Q13901
• A8K336
• D6W5F8
• Q05D64
• hC1D

Gene Name

• C1D

Ensembl ID

• ENST00000355848
• ENSP00000348107
• ENSG00000197223
• ENST00000409302
• ENSP00000386779
• ENST00000410067
• ENSP00000386468

Symbol

• LRP1
• hC1D
• Rrp47
• SUNCOR
• SUN-CoR

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
virus perturbation	0.85
histone modification site profile	0.81
transcription factor binding site profile	0.8
cell type or tissue	0.64
cellular component	0.61

Protein Classes

PANTHER Classes

Protein / Transcription Factor / Transcription Cofactor / Nuclear Nucleic Acid-binding Protein C1d

Protein / Nucleic Acid Binding / Nuclear Nucleic Acid-binding Protein C1d

DTO Classes

Protein / Transcription Factor / Transcription Cofactor / Nuclear Nucleic Acid-binding Protein C1d

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 120.13   (req: < 5)

Gene RIFs: 9   (req: <= 3)

Antibodies: 233   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 120.13   (req: >= 5)

Gene RIFs: 9   (req: > 3)

Antibodies: 233   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0