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Tbio
BYSL
Bystin

Protein Summary
Description
Required for processing of 20S pre-rRNA precursor and biogenesis of 40S ribosomal subunits. May be required for trophinin-dependent regulation of cell adhesion during implantation of human embryos. Bystin is expressed as a 2-kb major transcript and a 3.6-kb minor transcript in SNG-M cells and in human trophoblastic teratocarcinoma HT-H cells. Protein binding assays determined that bystin binds directly to trophinin and tastin, and that binding is enhanced when cytokeratins 8 and 18 are present. Immunocytochemistry of HT-H cells showed that bystin colocalizes with trophinin, tastin, and the cytokeratins, suggesting that these molecules form a complex in trophectoderm cells at the time of implantation. Using immunohistochemistry it was determined that trophinin and bystin are found in the placenta from the sixth week of pregnancy. Both proteins were localized in the cytoplasm of the syncytiotrophoblast in the chorionic villi and in endometrial decidual cells at the uteroplacental interfa ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000230340
  • ENSP00000230340
  • ENSG00000112578

Symbol
  • Enp1
  • BYSTIN
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
0.95
transcription factor binding site profile
0.9
drug perturbation
0.87
interacting protein
0.87
histone modification site profile
0.84


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 55.15   (req: < 5)
Gene RIFs: 4   (req: <= 3)
Antibodies: 73   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 55.15   (req: >= 5)
Gene RIFs: 4   (req: > 3)
Antibodies: 73   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (3)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
age at menarche
2
2
2
69.7
smoking status measurement
2
1
2
41.5
monocyte percentage of leukocytes
1
1
1
30.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
age at menarche
2
69.7
smoking status measurement
2
41.5
monocyte percentage of leukocytes
1
30.2
Orthologs (15)
1 – 5 of 15
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
bystin like
VGNC:2652
462688
Macaque
bystin like
694976
Mouse
MGI:1858419
53414
Rat
RGD:727959
359727
Dog
bystin like
VGNC:38570
474900
Species
Name
OMA
EggNOG
Inparanoid
Chimp
bystin like
Macaque
bystin like
Mouse
Rat
Dog
bystin like
Protein Data Bank (3)
1 – 3 of 3
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (4)
Major pathway of rRNA processing in the nucleolus and cytosol (R-HSA-6791226)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Major pathway of rRNA processing in the nucleolus and cytosol
Reactome
Metabolism of RNA
Reactome
rRNA processing
Reactome
rRNA processing in the nucleus and cytosol
Name
Explore in Pharos
Explore in Source
Major pathway of rRNA processing in the nucleolus and cytosol
Metabolism of RNA
rRNA processing
rRNA processing in the nucleus and cytosol
Gene Ontology Terms (17)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from High Throughput Direct Assay (HDA)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Protein-Protein Interactions (386)
1 – 10 of 386
DHPS
Tbio
Family: Enzyme
Novelty: 0.00776893
p_int: 0.999999572
p_ni: 4.28e-7
Score: 0.231
Data Source: BioPlex,STRINGDB
PARN
Tbio
Family: Enzyme
Novelty: 0.00738516
p_int: 0.999997793
p_ni: 0.000001602
p_wrong: 6.05e-7
Score: 0.642
Data Source: BioPlex,STRINGDB
NOP14
Tbio
Novelty: 0.08903014
p_int: 0.999993697
p_ni: 0.000006303
Score: 0.999
Data Source: BioPlex,STRINGDB
NOC4L
Tdark
Novelty: 0.39929311
p_int: 0.999988569
p_ni: 0.000011365
p_wrong: 6.6e-8
Score: 0.999
Data Source: BioPlex,STRINGDB
LTV1
Tbio
Novelty: 0.04050879
p_int: 0.999906331
p_ni: 0.000093669
Score: 0.999
Data Source: BioPlex,STRINGDB
SRFBP1
Tbio
Novelty: 0.10070972
p_int: 0.999851293
p_ni: 0.000148707
Score: 0.727
Data Source: BioPlex,STRINGDB
RRP12
Tbio
Novelty: 0.10034381
p_int: 0.999795495
p_ni: 0.000204505
Score: 0.984
Data Source: BioPlex,STRINGDB
TSR1
Tbio
Novelty: 0.01639069
p_int: 0.999760471
p_ni: 0.000239529
Score: 0.999
Data Source: BioPlex,STRINGDB
FAM207A
Tdark
Novelty: 0.62803282
p_int: 0.999607388
p_ni: 0.000392612
Score: 0.667
Data Source: BioPlex,STRINGDB
NOB1
Tbio
Novelty: 0.01209681
p_int: 0.992738638
p_ni: 0.007261362
Score: 0.999
Data Source: BioPlex,STRINGDB
Publication Statistics
PubMed Score  55.15

PubMed score by year
PubTator Score  16.91

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer