Tbio BYSL Bystin

Protein Summary

Description

Required for processing of 20S pre-rRNA precursor and biogenesis of 40S ribosomal subunits. May be required for trophinin-dependent regulation of cell adhesion during implantation of human embryos. Bystin is expressed as a 2-kb major transcript and a 3.6-kb minor transcript in SNG-M cells and in human trophoblastic teratocarcinoma HT-H cells. Protein binding assays determined that bystin binds directly to trophinin and tastin, and that binding is enhanced when cytokeratins 8 and 18 are present. Immunocytochemistry of HT-H cells showed that bystin colocalizes with trophinin, tastin, and the cytokeratins, suggesting that these molecules form a complex in trophectoderm cells at the time of implantation. Using immunohistochemistry it was determined that trophinin and bystin are found in the placenta from the sixth week of pregnancy. Both proteins were localized in the cytoplasm of the syncytiotrophoblast in the chorionic villi and in endometrial decidual cells at the uteroplacental interface. After week 10, the levels of trophinin, tastin, and bystin decreased and then disappeared from placental villi. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• Q13895
• Q6P5W4
• Q86W44
• Q96IP8

Gene Name

• BYSL

Ensembl ID

• ENST00000230340
• ENSP00000230340
• ENSG00000112578

Symbol

• Enp1
• BYSTIN

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
kinase perturbation	0.95
transcription factor binding site profile	0.9
drug perturbation	0.87
interacting protein	0.87
histone modification site profile	0.84

Related Tools

Target Illumination GWAS Analytics (TIGA)

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GENEVA

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

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GlyGen

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ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

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IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 55.15   (req: < 5)

Gene RIFs: 4   (req: <= 3)

Antibodies: 73   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 55.15   (req: >= 5)

Gene RIFs: 4   (req: > 3)

Antibodies: 73   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

GWAS Traits (3)

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GWAS Trait	EFO ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
age at menarche	EFO_0004703	2	2	2		69.7
smoking status measurement	EFO_0006527	2	1	2		41.5
monocyte percentage of leukocytes	EFO_0007989	1	1	1		30.2

• Explore on Target Illumination GWAS Analytics (TIGA)

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GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
age at menarche	EFO_0004703	2		69.7
smoking status measurement	EFO_0006527	2		41.5
monocyte percentage of leukocytes	EFO_0007989	1		30.2

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Orthologs (15)

1 – 5 of 15

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Chimp	bystin like	VGNC:2652	462688
Macaque	bystin like		694976
Mouse	bystin-like	MGI:1858419	53414
Rat	bystin-like	RGD:727959	359727
Dog	bystin like	VGNC:38570	474900

Species	Name	OMA	EggNOG	Inparanoid
Chimp	bystin like
Macaque	bystin like
Mouse	bystin-like
Rat	bystin-like
Dog	bystin like

Protein Data Bank (3)

1 – 3 of 3

PDB Structure Id	Ligand	Method	Resolution (Å)	M.W. (kDa)	Pub Year	Title

PDB Structure Id	M.W.	Resolution	Pub Year

Pathways (4)

Reactome (4)

Major pathway of rRNA processing in the nucleolus and cytosol (R-HSA-6791226)

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Data Source	Name	Explore in Pharos	Explore in Source
Reactome	Major pathway of rRNA processing in the nucleolus and cytosol	183 targets	R-HSA-6791226
Reactome	Metabolism of RNA	686 targets	R-HSA-8953854
Reactome	rRNA processing	217 targets	R-HSA-72312
Reactome	rRNA processing in the nucleus and cytosol	193 targets	R-HSA-8868773

Name	Explore in Pharos	Explore in Source
Major pathway of rRNA processing in the nucleolus and cytosol	183 targets	R-HSA-6791226
Metabolism of RNA	686 targets	R-HSA-8953854
rRNA processing	217 targets	R-HSA-72312
rRNA processing in the nucleus and cytosol	193 targets	R-HSA-8868773

Gene Ontology Terms (17)

Functions (2)

Components (9)

Processes (6)

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10

1 – 2 of 2

GO Term	Evidence	Assigned by
RNA binding	Inferred from High Throughput Direct Assay (HDA)	UniProtKB
snoRNA binding	Inferred from Biological aspect of Ancestor (IBA)	GO_Central

Protein-Protein Interactions (386)

Explore Interacting Targets

1 – 10 of 386

• See Interactions on String-DB

DHPS

Tbio

Family: Enzyme

Novelty: 0.00776893

p_int: 0.999999572

p_ni: 4.28e-7

Score: 0.231

Data Source: BioPlex,STRINGDB

PARN

Tbio

Family: Enzyme

Novelty: 0.00738516

p_int: 0.999997793

p_ni: 0.000001602

p_wrong: 6.05e-7

Score: 0.642

Data Source: BioPlex,STRINGDB

NOP14

Tbio

Novelty: 0.08903014

p_int: 0.999993697

p_ni: 0.000006303

Score: 0.999

Data Source: BioPlex,STRINGDB

NOC4L

Tdark

Novelty: 0.39929311

p_int: 0.999988569

p_ni: 0.000011365

p_wrong: 6.6e-8

Score: 0.999

Data Source: BioPlex,STRINGDB

LTV1

Tbio

Novelty: 0.04050879

p_int: 0.999906331

p_ni: 0.000093669

Score: 0.999

Data Source: BioPlex,STRINGDB

SRFBP1

Tbio

Novelty: 0.10070972

p_int: 0.999851293

p_ni: 0.000148707

Score: 0.727

Data Source: BioPlex,STRINGDB

RRP12

Tbio

Novelty: 0.10034381

p_int: 0.999795495

p_ni: 0.000204505

Score: 0.984

Data Source: BioPlex,STRINGDB

TSR1

Tbio

Novelty: 0.01639069

p_int: 0.999760471

p_ni: 0.000239529

Score: 0.999

Data Source: BioPlex,STRINGDB

FAM207A

Tdark

Novelty: 0.62803282

p_int: 0.999607388

p_ni: 0.000392612

Score: 0.667

Data Source: BioPlex,STRINGDB

NOB1

Tbio

Novelty: 0.01209681

p_int: 0.992738638

p_ni: 0.007261362

Score: 0.999

Data Source: BioPlex,STRINGDB

Publication Statistics

PubMed Score  55.15

PubMed score by year

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PubTator Score  16.91

PubTator score by year

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Amino Acid Sequence

Residue Counts

Protein Sequence

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UniProt Keyword Find Similar Targets

3D-structure
Complete proteome
Cytoplasm
Methylation
Nucleus
Phosphoprotein
Polymorphism
Reference proteome
Ribosome biogenesis

GWAS Trait Find Similar Targets

age at menarche
monocyte percentage of leukocytes
smoking status measurement

MGI Phenotype Find Similar Targets

mortality/aging