Protein Summary
Required for processing of 20S pre-rRNA precursor and biogenesis of 40S ribosomal subunits. May be required for trophinin-dependent regulation of cell adhesion during implantation of human embryos. Bystin is expressed as a 2-kb major transcript and a 3.6-kb minor transcript in SNG-M cells and in human trophoblastic teratocarcinoma HT-H cells. Protein binding assays determined that bystin binds directly to trophinin and tastin, and that binding is enhanced when cytokeratins 8 and 18 are present. Immunocytochemistry of HT-H cells showed that bystin colocalizes with trophinin, tastin, and the cytokeratins, suggesting that these molecules form a complex in trophectoderm cells at the time of implantation. Using immunohistochemistry it was determined that trophinin and bystin are found in the placenta from the sixth week of pregnancy. Both proteins were localized in the cytoplasm of the syncytiotrophoblast in the chorionic villi and in endometrial decidual cells at the uteroplacental interfa ...more
- ENST00000230340
- ENSP00000230340
- ENSG00000112578
- Enp1
- BYSTIN
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
---|---|---|---|
kinase perturbation | 0.95 | ||
transcription factor binding site profile | 0.9 | ||
drug perturbation | 0.87 | ||
interacting protein | 0.87 | ||
histone modification site profile | 0.84 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 54.97 (req: < 5)
Gene RIFs: 4 (req: <= 3)
Antibodies: 73 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 54.97 (req: >= 5)
Gene RIFs: 4 (req: > 3)
Antibodies: 73 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 8
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
Related Tools

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (386)
DHPS
Family: Enzyme
Novelty: 0.00776893
p_int: 0.999999572
p_ni: 4.28e-7
Score: 0.231
Data Source: BioPlex,STRINGDB
PARN
Family: Enzyme
Novelty: 0.00738516
p_int: 0.999997793
p_ni: 0.000001602
p_wrong: 6.05e-7
Score: 0.642
Data Source: BioPlex,STRINGDB
NOP14
Novelty: 0.08903014
p_int: 0.999993697
p_ni: 0.000006303
Score: 0.999
Data Source: BioPlex,STRINGDB
NOC4L
Novelty: 0.39929311
p_int: 0.999988569
p_ni: 0.000011365
p_wrong: 6.6e-8
Score: 0.999
Data Source: BioPlex,STRINGDB
LTV1
Novelty: 0.04050879
p_int: 0.999906331
p_ni: 0.000093669
Score: 0.999
Data Source: BioPlex,STRINGDB
SRFBP1
Novelty: 0.10070972
p_int: 0.999851293
p_ni: 0.000148707
Score: 0.727
Data Source: BioPlex,STRINGDB
RRP12
Novelty: 0.10034381
p_int: 0.999795495
p_ni: 0.000204505
Score: 0.984
Data Source: BioPlex,STRINGDB
TSR1
Novelty: 0.01639069
p_int: 0.999760471
p_ni: 0.000239529
Score: 0.999
Data Source: BioPlex,STRINGDB
FAM207A
Novelty: 0.62803282
p_int: 0.999607388
p_ni: 0.000392612
Score: 0.667
Data Source: BioPlex,STRINGDB
NOB1
Novelty: 0.01209681
p_int: 0.992738638
p_ni: 0.007261362
Score: 0.999
Data Source: BioPlex,STRINGDB
Nearest Tclin Targets
Pathways (4)
Reactome (4)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|---|
Reactome | Major pathway of rRNA processing in the nucleolus and cytosol | ||||
Reactome | Metabolism of RNA | ||||
Reactome | rRNA processing | ||||
Reactome | rRNA processing in the nucleus and cytosol | ||||
Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|
Major pathway of rRNA processing in the nucleolus and cytosol | ||||
Metabolism of RNA | ||||
rRNA processing | ||||
rRNA processing in the nucleus and cytosol | ||||
Viral Interactions (0)
Gene Ontology Terms (17)
Functions (2)
Components (9)
Processes (6)
GO Term | Evidence | Assigned by | ||
---|---|---|---|---|
Inferred from High Throughput Direct Assay (HDA) | UniProtKB | |||
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Disease Associations ()
GWAS Traits (25)
Items per page:
1 – 5 of 25
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|---|---|
mean corpuscular volume | 7 | 15 | 19 | 99.9 | |||||
mean reticulocyte volume | 1 | 9 | 9 | 99.8 | |||||
reticulocyte count | 5 | 7 | 15 | 99.3 | |||||
red blood cell distribution width | 4 | 6 | 11 | 99.2 | |||||
mean corpuscular hemoglobin | 4 | 5 | 6 | 98.8 | |||||
Items per page:
1 – 5 of 25
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|
mean corpuscular volume | 19 | 99.9 | |||||
mean reticulocyte volume | 9 | 99.8 | |||||
reticulocyte count | 15 | 99.3 | |||||
red blood cell distribution width | 11 | 99.2 | |||||
mean corpuscular hemoglobin | 6 | 98.8 | |||||
Find similar targets by:
IDG Resources
Orthologs (15)
1 – 5 of 15
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|---|---|
Chimp | bystin like | VGNC:2652 | 462688 | |||||
Macaque | bystin like | 694976 | ||||||
Mouse | MGI:1858419 | 53414 | ||||||
Rat | RGD:727959 | 359727 | ||||||
Dog | bystin like | VGNC:38570 | 474900 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|
Chimp | bystin like | |||||
Macaque | bystin like | |||||
Mouse | ||||||
Rat | ||||||
Dog | bystin like | |||||
Publication Statistics
PubMed Score 54.97
PubMed score by year
PubTator Score 16.91
PubTator score by year
Related Publications
Text Mined References (27)
GeneRif Annotations (4)
Items per page:
0 of 0
PMID | Year | Title |
---|