Tbio GTF2H3 General transcription factor IIH subunit 3

Protein Summary

Description

Component of the general transcription and DNA repair factor IIH (TFIIH) core complex, which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA and, when complexed to CAK, in RNA transcription by RNA polymerase II. In NER, TFIIH acts by opening DNA around the lesion to allow the excision of the damaged oligonucleotide and its replacement by a new DNA fragment. In transcription, TFIIH has an essential role in transcription initiation. When the pre-initiation complex (PIC) has been established, TFIIH is required for promoter opening and promoter escape. Phosphorylation of the C-terminal tail (CTD) of the largest subunit of RNA polymerase II by the kinase module CAK controls the initiation of transcription. This gene encodes a member of the TFB4 family. The encoded protein is a subunit of the core-TFIIH basal transcription factor and localizes to the nucleus. The encoded protein is involved in RNA transcription by RNA polymerase II and nucleotide excision repair and associates with the Cdk-activating kinase complex. Alternative splicing results in multiple transcript variants. A related pseudogene has been identified on chromosome 14. [provided by RefSeq, Dec 2012]

Uniprot Accession IDs

• Q13889
• B2R819
• B4DNZ6
• Q7L0G0
• Q96AT7

Gene Name

• GTF2H3

Ensembl ID

• ENST00000228955
• ENSP00000228955
• ENSG00000111358
• ENST00000543341
• ENSP00000445162

Symbol

• P34
• BTF2
• TFB4
• TFIIH

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
molecular function	0.95
kinase perturbation	0.93
histone modification site profile	0.91
biological process	0.85
transcription factor binding site profile	0.74

Protein Classes

PANTHER Classes

Protein / Transcription Factor / General Transcription Factor Iih Subunit 3

Protein / Nucleic Acid Binding / General Transcription Factor Iih Subunit 3

DTO Classes

Protein / Nucleic Acid Binding / General Transcription Factor Iih Subunit 3

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 10.56   (req: < 5)

Gene RIFs: 3   (req: <= 3)

Antibodies: 105   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 10.56   (req: >= 5)

Gene RIFs: 3   (req: > 3)

Antibodies: 105   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 20

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0