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Tbio
GTF2H3
General transcription factor IIH subunit 3

Protein Summary
Description
Component of the general transcription and DNA repair factor IIH (TFIIH) core complex, which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA and, when complexed to CAK, in RNA transcription by RNA polymerase II. In NER, TFIIH acts by opening DNA around the lesion to allow the excision of the damaged oligonucleotide and its replacement by a new DNA fragment. In transcription, TFIIH has an essential role in transcription initiation. When the pre-initiation complex (PIC) has been established, TFIIH is required for promoter opening and promoter escape. Phosphorylation of the C-terminal tail (CTD) of the largest subunit of RNA polymerase II by the kinase module CAK controls the initiation of transcription. This gene encodes a member of the TFB4 family. The encoded protein is a subunit of the core-TFIIH basal transcription factor and localizes to the nucleus. The encoded protein is involved in RNA transcription by RNA polymerase II and nucleot ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000228955
  • ENSP00000228955
  • ENSG00000111358
  • ENST00000543341
  • ENSP00000445162

Symbol
  • P34
  • BTF2
  • TFB4
  • TFIIH
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.95
kinase perturbation
0.93
histone modification site profile
0.91
biological process
0.85
transcription factor binding site profile
0.74


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 8.87   (req: < 5)
Gene RIFs: 3   (req: <= 3)
Antibodies: 105   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 8.87   (req: >= 5)
Gene RIFs: 3   (req: > 3)
Antibodies: 105   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 20
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (214)
ERCC3
Tbio
Family:  Enzyme
Novelty:  0.00978601
p_int:  1
Score:  0.999
Data Source:  BioPlex,STRINGDB
GTF2H5
Tbio
Novelty:  0.03493285
p_int:  1
Score:  0.999
Data Source:  BioPlex,STRINGDB
GTF2H1
Tbio
Novelty:  0.01736328
p_int:  0.999999983
p_ni:  1.6e-8
Score:  0.999
Data Source:  BioPlex,STRINGDB
GTF2H4
Tbio
Novelty:  0.03140561
p_int:  0.999999394
p_ni:  6.07e-7
Score:  0.999
Data Source:  BioPlex,STRINGDB
GTF2H2
Tbio
Novelty:  0.02761619
p_int:  0.999994944
p_ni:  0.000005056
Score:  0.999
Data Source:  BioPlex,STRINGDB
ZNF784
Tdark
Family:  TF
Novelty:  17.08860759
p_int:  0.987710622
p_ni:  0.004487326
p_wrong:  0.007802052
Data Source:  BioPlex
ERCC2
Tchem
Family:  Enzyme
Novelty:  0.00240155
Score:  0.999
Data Source:  STRINGDB
MNAT1
Tbio
Family:  Enzyme
Novelty:  0.02484936
Score:  0.999
Data Source:  STRINGDB
CCNH
Tbio
Novelty:  0.00693072
Score:  0.999
Data Source:  STRINGDB
GTF2B
Tbio
Novelty:  0.00179492
Score:  0.998
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (56)
DNA Repair (R-HSA-73894)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 47
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
DNA Repair
Reactome
Disease
Reactome
Dual Incision in GG-NER
Reactome
Dual incision in TC-NER
Reactome
Epigenetic regulation of gene expression
Name
Explore in Pharos
Explore in Source
DNA Repair
Disease
Dual Incision in GG-NER
Dual incision in TC-NER
Epigenetic regulation of gene expression
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (27)
Find Similar Targets
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Physical Interaction (IPI)
UniProtKB
Traceable Author Statement (TAS)
ProtInc
Traceable Author Statement (TAS)
ProtInc
Non-traceable Author Statement (NAS)
ProtInc
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Disease Associations ()
No disease associations found
GWAS Traits (9)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
waist-hip ratio
1
11
11
94
BMI-adjusted waist-hip ratio
1
11
11
93.4
waist circumference
1
7
7
89.8
BMI-adjusted waist circumference
1
8
8
89.1
high density lipoprotein cholesterol measurement
1
3
3
76.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
waist-hip ratio
11
94
BMI-adjusted waist-hip ratio
11
93.4
waist circumference
7
89.8
BMI-adjusted waist circumference
8
89.1
high density lipoprotein cholesterol measurement
3
76.3
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
general transcription factor IIH subunit 3
VGNC:8417
452352
Mouse
MGI:1277143
209357
Rat
RGD:1305494
288651
Horse
general transcription factor IIH subunit 3
VGNC:18640
100059174
Cow
general transcription factor IIH subunit 3
VGNC:29696
511896
Species
Name
OMA
EggNOG
Inparanoid
Chimp
general transcription factor IIH subunit 3
Mouse
Rat
Horse
general transcription factor IIH subunit 3
Cow
general transcription factor IIH subunit 3
Publication Statistics
PubMed Score 8.87
PubMed score by year
PubTator Score 79.70
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title