Protein Summary
Transcription factor that binds to GC box promoter elements. Activates the transcription of these genes. This gene encodes a member of the Kruppel-like factor subfamily of zinc finger proteins. The encoded protein is a transcriptional activator that binds directly to a specific recognition motif in the promoters of target genes. This protein acts downstream of multiple different signaling pathways and is regulated by post-translational modification. It may participate in both promoting and suppressing cell proliferation. Expression of this gene may be changed in a variety of different cancers and in cardiovascular disease. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2013]
- ENST00000377687
- ENSP00000366915
- ENSG00000102554
- ENST00000539231
- ENSP00000440407
- BTEB2
- CKLF
- IKLF
- CKLF
- IKLF
- BTEB2
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
PubMedID | 0.98 | ||
transcription factor binding site profile | 0.91 | ||
hub protein | 0.9 | ||
biological process | 0.87 | ||
molecular function | 0.86 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 389.18 (req: < 5)
Gene RIFs: 207 (req: <= 3)
Antibodies: 297 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 389.18 (req: >= 5)
Gene RIFs: 207 (req: > 3)
Antibodies: 297 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 21
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligands: 40
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0