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Tclin
TUBB2A
Tubulin beta-2A chain

Protein Summary
Description
Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain (By similarity). Microtubules, key participants in processes such as mitosis and intracellular transport, are composed of heterodimers of alpha- and beta-tubulins. The protein encoded by this gene is a beta-tubulin. Defects in this gene are associated with complex cortical dysplasia with other brain malformations-5. Two transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jul 2015]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000333628
  • ENSP00000369703
  • ENSG00000137267

Symbol
  • TUBB2
  • TUBB
  • TUBB2
  • CDCBM5
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
interacting protein
1
protein complex
1
gene perturbation
0.97
protein domain
0.97
hub protein
0.95


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 99.1   (req: < 5)
Gene RIFs: 12   (req: <= 3)
Antibodies: 331   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 99.1   (req: >= 5)
Gene RIFs: 12   (req: > 3)
Antibodies: 331   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 13
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (13)
paclitaxel
Rendered image for paclitaxel
docetaxel
Rendered image for docetaxel
brentuximab vedotin
no chemical structure image available
vinblastine
Rendered image for vinblastine
vinorelbine
Rendered image for vinorelbine
trastuzumab emtansine
no chemical structure image available
polatuzumab vedotin
no chemical structure image available
enfortumab vedotin
no chemical structure image available
ixabepilone
Rendered image for ixabepilone
vincristine
Rendered image for vincristine
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (176)
EML2
Tbio
Novelty:  0.09538181
p_int:  0.999999696
p_ni:  3.04e-7
p_wrong:  1e-9
Score:  0.825
Data Source:  BioPlex,STRINGDB
ARL2
Tbio
Family:  Enzyme
Novelty:  0.01989908
p_int:  0.999998949
p_ni:  0.000001051
Score:  0.973
Data Source:  BioPlex,STRINGDB
EML1
Tbio
Novelty:  0.02262549
p_int:  0.999998922
p_ni:  0.000001078
Score:  0.836
Data Source:  BioPlex,STRINGDB
TBCD
Tbio
Novelty:  0.01161221
p_int:  0.999534936
p_ni:  0.000465064
Score:  0.986
Data Source:  BioPlex,STRINGDB
EML4
Tbio
Novelty:  0.00217772
p_int:  0.997125554
p_ni:  0.002874446
Score:  0.69
Data Source:  BioPlex,STRINGDB
TTC5
Tbio
Novelty:  0.12127698
p_int:  0.995830699
p_ni:  0.004169301
Score:  0.528
Data Source:  BioPlex,STRINGDB
CAPS
Tbio
Novelty:  0.04549022
p_int:  0.989483734
p_ni:  0.010516266
Data Source:  BioPlex
TUBB
Tclin
Novelty:  0.0038007
p_int:  0.973814576
p_ni:  0.026185424
Score:  0.824
Data Source:  BioPlex,STRINGDB
MFAP5
Tbio
Novelty:  0.01839035
p_int:  0.930024852
p_ni:  0.069975148
Data Source:  BioPlex
CCT2
Tbio
Novelty:  0.01967139
p_int:  0.914702383
p_ni:  0.085297617
Score:  0.931
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (18)
Carboxyterminal post-translational modifications of tubulin (R-HSA-8955332)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 9
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Carboxyterminal post-translational modifications of tubulin
Reactome
Chaperonin-mediated protein folding
Reactome
Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding
Reactome
Formation of tubulin folding intermediates by CCT/TriC
Reactome
Metabolism of proteins
Name
Explore in Pharos
Explore in Source
Carboxyterminal post-translational modifications of tubulin
Chaperonin-mediated protein folding
Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding
Formation of tubulin folding intermediates by CCT/TriC
Metabolism of proteins
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
red blood cell distribution width
3
2
3
71.6
mean reticulocyte volume
1
1
1
4.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
red blood cell distribution width
3
71.6
mean reticulocyte volume
1
4.7
IDG Resources
No IDG generated resources found
Orthologs (8)
1 – 5 of 8
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
tubulin beta-2B chain
708415
Mouse
MGI:107861
22151
Rat
RGD:1588452
498736
Horse
tubulin beta-2B chain
100050361
Cow
tubulin beta 2A class IIa
VGNC:54244
100295973
Species
Name
OMA
EggNOG
Inparanoid
Macaque
tubulin beta-2B chain
Mouse
Rat
Horse
tubulin beta-2B chain
Cow
tubulin beta 2A class IIa
Publication Statistics
PubMed Score 99.10
PubMed score by year
PubTator Score 14.39
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title