Tbio SNTB1 Beta-1-syntrophin

Protein Summary

Description

Adapter protein that binds to and probably organizes the subcellular localization of a variety of membrane proteins. May link various receptors to the actin cytoskeleton and the dystrophin glycoprotein complex. Dystrophin is a large, rod-like cytoskeletal protein found at the inner surface of muscle fibers. Dystrophin is missing in Duchenne Muscular Dystrophy patients and is present in reduced amounts in Becker Muscular Dystrophy patients. The protein encoded by this gene is a peripheral membrane protein found associated with dystrophin and dystrophin-related proteins. This gene is a member of the syntrophin gene family, which contains at least two other structurally-related genes. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• Q13884
• A8K9E0
• O14912
• Q4KMG8

Gene Name

• SNTB1

Ensembl ID

• ENST00000395601
• ENSP00000378965
• ENSG00000172164
• ENST00000517992
• ENSP00000431124

Symbol

• SNT2B1
• A1B
• SNT2
• BSYN2
• 59-DAP
• DAPA1B
• SNT2B1
• TIP-43

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
gene perturbation	0.88
cell type or tissue	0.73
PubMedID	0.73
phenotype	0.65
microRNA	0.63

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 18.77   (req: < 5)

Gene RIFs: 5   (req: <= 3)

Antibodies: 140   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 18.77   (req: >= 5)

Gene RIFs: 5   (req: > 3)

Antibodies: 140   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Protein Sequence and Structure

Residue Counts

Protein Sequence

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Expression Data (0 Tissues)

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No expression data found

Related Tools

Target Illumination GWAS Analytics (TIGA)

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

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GENEVA

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

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GlyGen

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

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ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

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Approved Drugs (0)

No approved drugs found

Active Ligands (0)

No active ligands found

Protein-Protein Interactions (59)

Explore Interacting Targets

1 – 10 of 59

• See Interactions on String-DB

SNTG2

Tbio

Novelty:  0.04056715

p_int:  0.999999985

p_ni:  3e-9

p_wrong:  1.3e-8

Score:  0.963

Data Source:  BioPlex,STRINGDB

SNTG1

Tbio

Novelty:  0.05608114

p_int:  0.999999983

p_ni:  1.7e-8

Score:  0.821

Data Source:  BioPlex,STRINGDB

DTNB

Tbio

Novelty:  0.0586565

p_int:  0.999999965

p_ni:  3.5e-8

Score:  0.684

Data Source:  BioPlex,STRINGDB

DMD

Tclin

Novelty:  0.00025661

p_int:  0.999999952

p_ni:  2e-9

p_wrong:  4.6e-8

Score:  0.987

Data Source:  BioPlex,STRINGDB

HMG20A

Tbio

Family:  TF

Novelty:  0.11994252

p_int:  0.99999467

p_ni:  0.000005295

p_wrong:  3.5e-8

Score:  0.207

Data Source:  BioPlex,STRINGDB

NDEL1

Tbio

Novelty:  0.01241819

p_int:  0.999976218

p_ni:  0.000023782

Score:  0.173

Data Source:  BioPlex,STRINGDB

TAGAP

Tbio

Family:  Enzyme

Novelty:  0.04450409

p_int:  0.999929609

p_ni:  0.000070391

Data Source:  BioPlex

SGCA

Tbio

Novelty:  0.00442268

Score:  0.925

Data Source:  STRINGDB

UTRN

Tchem

Novelty:  0.0018541

Score:  0.92

Data Source:  STRINGDB

DTNA

Tbio

Novelty:  0.01165754

Score:  0.896

Data Source:  STRINGDB

Nearest Tclin Targets

Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.

Pathways (0)

No pathways found

Viral Interactions (0)

No viral interactions found

Gene Ontology Terms (12)

Functions (4)

Components (7)

Processes (1)

Find Similar Targets

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10

1 – 4 of 4

GO Term	Evidence	Assigned by
actin binding	Inferred from Electronic Annotation (IEA)	UniProtKB-KW
calmodulin binding	Inferred from Electronic Annotation (IEA)	UniProtKB-KW
PDZ domain binding	Inferred from Electronic Annotation (IEA)	Ensembl
structural molecule activity	Inferred from Electronic Annotation (IEA)	InterPro

Disease Associations ()

No disease associations found

GWAS Traits (3)

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5

1 – 3 of 3

GWAS Trait	EFO ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
high density lipoprotein cholesterol measurement	EFO_0004612	6	4	7		86.9
apolipoprotein A 1 measurement	EFO_0004614	2	2	2		74.9
pathological myopia	EFO_0004207	1	1	0	1.3	33.1

• Explore on Target Illumination GWAS Analytics (TIGA)

Items per page:

5

1 – 3 of 3

GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
high density lipoprotein cholesterol measurement	EFO_0004612	7		86.9
apolipoprotein A 1 measurement	EFO_0004614	2		74.9
pathological myopia	EFO_0004207	0	1.3	33.1

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Find similar targets by:

UniProt Keyword Find Similar Targets

No Header	No Header
Acetylation
Actin-binding
Alternative splicing
Calcium
Calmodulin-binding
Cell junction
Cell membrane
Complete proteome
Cytoplasm
Cytoskeleton

GWAS Trait Find Similar Targets

No Header	No Header
apolipoprotein A 1 measurement
high density lipoprotein cholesterol measurement
pathological myopia

IDG Resources

No IDG generated resources found

Orthologs (12)

1 – 5 of 12

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Chimp	syntrophin beta 1	VGNC:6574	464362
Macaque	syntrophin beta 1		703245
Mouse	syntrophin, basic 1	MGI:101781	20649
Rat	syntrophin, beta 1	RGD:1307728	299940
Dog	syntrophin beta 1	VGNC:46613	482030

Species	Name	OMA	EggNOG	Inparanoid
Chimp	syntrophin beta 1
Macaque	syntrophin beta 1
Mouse	syntrophin, basic 1
Rat	syntrophin, beta 1
Dog	syntrophin beta 1

Publication Statistics

PubMed Score 18.77

PubMed score by year

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PubTator Score 55.02

PubTator score by year

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Related Publications

Text Mined References (31)

GeneRif Annotations (5)

Items per page:

10

0 of 0

PMID	Year	Title