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Tbio
SNTB1
Beta-1-syntrophin

Protein Summary
Description
Adapter protein that binds to and probably organizes the subcellular localization of a variety of membrane proteins. May link various receptors to the actin cytoskeleton and the dystrophin glycoprotein complex. Dystrophin is a large, rod-like cytoskeletal protein found at the inner surface of muscle fibers. Dystrophin is missing in Duchenne Muscular Dystrophy patients and is present in reduced amounts in Becker Muscular Dystrophy patients. The protein encoded by this gene is a peripheral membrane protein found associated with dystrophin and dystrophin-related proteins. This gene is a member of the syntrophin gene family, which contains at least two other structurally-related genes. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000395601
  • ENSP00000378965
  • ENSG00000172164
  • ENST00000517992
  • ENSP00000431124

Symbol
  • SNT2B1
  • A1B
  • SNT2
  • BSYN2
  • 59-DAP
  • DAPA1B
  • SNT2B1
  • TIP-43
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
gene perturbation
0.88
cell type or tissue
0.73
PubMedID
0.73
phenotype
0.65
microRNA
0.63


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 18.77   (req: < 5)
Gene RIFs: 5   (req: <= 3)
Antibodies: 140   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 18.77   (req: >= 5)
Gene RIFs: 5   (req: > 3)
Antibodies: 140   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (59)
SNTG2
Tbio
Novelty:  0.04056715
p_int:  0.999999985
p_ni:  3e-9
p_wrong:  1.3e-8
Score:  0.963
Data Source:  BioPlex,STRINGDB
SNTG1
Tbio
Novelty:  0.05608114
p_int:  0.999999983
p_ni:  1.7e-8
Score:  0.821
Data Source:  BioPlex,STRINGDB
DTNB
Tbio
Novelty:  0.0586565
p_int:  0.999999965
p_ni:  3.5e-8
Score:  0.684
Data Source:  BioPlex,STRINGDB
DMD
Tclin
Novelty:  0.00025661
p_int:  0.999999952
p_ni:  2e-9
p_wrong:  4.6e-8
Score:  0.987
Data Source:  BioPlex,STRINGDB
HMG20A
Tbio
Family:  TF
Novelty:  0.11994252
p_int:  0.99999467
p_ni:  0.000005295
p_wrong:  3.5e-8
Score:  0.207
Data Source:  BioPlex,STRINGDB
NDEL1
Tbio
Novelty:  0.01241819
p_int:  0.999976218
p_ni:  0.000023782
Score:  0.173
Data Source:  BioPlex,STRINGDB
TAGAP
Tbio
Family:  Enzyme
Novelty:  0.04450409
p_int:  0.999929609
p_ni:  0.000070391
Data Source:  BioPlex
SGCA
Tbio
Novelty:  0.00442268
Score:  0.925
Data Source:  STRINGDB
UTRN
Tchem
Novelty:  0.0018541
Score:  0.92
Data Source:  STRINGDB
DTNA
Tbio
Novelty:  0.01165754
Score:  0.896
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (3)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
high density lipoprotein cholesterol measurement
6
4
7
86.9
apolipoprotein A 1 measurement
2
2
2
74.9
1
1
0
1.3
33.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
high density lipoprotein cholesterol measurement
7
86.9
apolipoprotein A 1 measurement
2
74.9
0
1.3
33.1
IDG Resources
No IDG generated resources found
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
syntrophin beta 1
VGNC:6574
464362
Macaque
syntrophin beta 1
703245
Mouse
MGI:101781
20649
Rat
RGD:1307728
299940
Dog
syntrophin beta 1
VGNC:46613
482030
Species
Name
OMA
EggNOG
Inparanoid
Chimp
syntrophin beta 1
Macaque
syntrophin beta 1
Mouse
Rat
Dog
syntrophin beta 1
Publication Statistics
PubMed Score 18.77
PubMed score by year
PubTator Score 55.02
PubTator score by year
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Related Publications
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PMID
Year
Title