Protein Summary
Adapter protein that binds to and probably organizes the subcellular localization of a variety of membrane proteins. May link various receptors to the actin cytoskeleton and the dystrophin glycoprotein complex. Dystrophin is a large, rod-like cytoskeletal protein found at the inner surface of muscle fibers. Dystrophin is missing in Duchenne Muscular Dystrophy patients and is present in reduced amounts in Becker Muscular Dystrophy patients. The protein encoded by this gene is a peripheral membrane protein found associated with dystrophin and dystrophin-related proteins. This gene is a member of the syntrophin gene family, which contains at least two other structurally-related genes. [provided by RefSeq, Jul 2008]
- ENST00000395601
- ENSP00000378965
- ENSG00000172164
- ENST00000517992
- ENSP00000431124
- SNT2B1
- A1B
- SNT2
- BSYN2
- 59-DAP
- DAPA1B
- SNT2B1
- TIP-43
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
---|---|---|---|
gene perturbation | 0.88 | ||
cell type or tissue | 0.73 | ||
PubMedID | 0.73 | ||
phenotype | 0.65 | ||
microRNA | 0.63 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 18.77 (req: < 5)
Gene RIFs: 5 (req: <= 3)
Antibodies: 140 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 18.77 (req: >= 5)
Gene RIFs: 5 (req: > 3)
Antibodies: 140 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 5
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
Related Tools

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (59)
SNTG2
Novelty: 0.04056715
p_int: 0.999999985
p_ni: 3e-9
p_wrong: 1.3e-8
Score: 0.963
Data Source: BioPlex,STRINGDB
SNTG1
Novelty: 0.05608114
p_int: 0.999999983
p_ni: 1.7e-8
Score: 0.821
Data Source: BioPlex,STRINGDB
DTNB
Novelty: 0.0586565
p_int: 0.999999965
p_ni: 3.5e-8
Score: 0.684
Data Source: BioPlex,STRINGDB
DMD
Novelty: 0.00025661
p_int: 0.999999952
p_ni: 2e-9
p_wrong: 4.6e-8
Score: 0.987
Data Source: BioPlex,STRINGDB
HMG20A
Family: TF
Novelty: 0.11994252
p_int: 0.99999467
p_ni: 0.000005295
p_wrong: 3.5e-8
Score: 0.207
Data Source: BioPlex,STRINGDB
NDEL1
Novelty: 0.01241819
p_int: 0.999976218
p_ni: 0.000023782
Score: 0.173
Data Source: BioPlex,STRINGDB
TAGAP
Family: Enzyme
Novelty: 0.04450409
p_int: 0.999929609
p_ni: 0.000070391
Data Source: BioPlex
Nearest Tclin Targets
Pathways (0)
Viral Interactions (0)
Gene Ontology Terms (12)
Functions (4)
Components (7)
Processes (1)
GO Term | Evidence | Assigned by | ||
---|---|---|---|---|
Inferred from Electronic Annotation (IEA) | UniProtKB-KW | |||
Inferred from Electronic Annotation (IEA) | UniProtKB-KW | |||
Inferred from Electronic Annotation (IEA) | Ensembl | |||
Inferred from Electronic Annotation (IEA) | InterPro | |||
Disease Associations ()
GWAS Traits (3)
Items per page:
1 – 3 of 3
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|---|---|
high density lipoprotein cholesterol measurement | 6 | 4 | 7 | 86.9 | |||||
apolipoprotein A 1 measurement | 2 | 2 | 2 | 74.9 | |||||
1 | 1 | 0 | 1.3 | 33.1 | |||||
Items per page:
1 – 3 of 3
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|
high density lipoprotein cholesterol measurement | 7 | 86.9 | |||||
apolipoprotein A 1 measurement | 2 | 74.9 | |||||
0 | 1.3 | 33.1 | |||||
Find similar targets by:
IDG Resources
Orthologs (12)
1 – 5 of 12
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|---|---|
Chimp | syntrophin beta 1 | VGNC:6574 | 464362 | |||||
Macaque | syntrophin beta 1 | 703245 | ||||||
Mouse | MGI:101781 | 20649 | ||||||
Rat | RGD:1307728 | 299940 | ||||||
Dog | syntrophin beta 1 | VGNC:46613 | 482030 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|
Chimp | syntrophin beta 1 | |||||
Macaque | syntrophin beta 1 | |||||
Mouse | ||||||
Rat | ||||||
Dog | syntrophin beta 1 | |||||
Publication Statistics
PubMed Score 18.77
PubMed score by year
PubTator Score 55.02
PubTator score by year
Related Publications
Text Mined References (31)
GeneRif Annotations (5)
Items per page:
0 of 0
PMID | Year | Title |
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