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Tchem
PTK6
Protein-tyrosine kinase 6

Protein Summary
Description
Non-receptor tyrosine-protein kinase implicated in the regulation of a variety of signaling pathways that control the differentiation and maintenance of normal epithelia, as well as tumor growth. Function seems to be context dependent and differ depending on cell type, as well as its intracellular localization. A number of potential nuclear and cytoplasmic substrates have been identified. These include the RNA-binding proteins: KHDRBS1/SAM68, KHDRBS2/SLM1, KHDRBS3/SLM2 and SFPQ/PSF; transcription factors: STAT3 and STAT5A/B and a variety of signaling molecules: ARHGAP35/p190RhoGAP, PXN/paxillin, BTK/ATK, STAP2/BKS. Associates also with a variety of proteins that are likely upstream of PTK6 in various signaling pathways, or for which PTK6 may play an adapter-like role. These proteins include ADAM15, EGFR, ERBB2, ERBB3 and IRS4. In normal or non-tumorigenic tissues, PTK6 promotes cellular differentiation and apoptosis. In tumors PTK6 contributes to cancer progression by sensitizing cells ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000217185
  • ENSP00000217185
  • ENSG00000101213
  • ENST00000542869
  • ENSP00000442460

Symbol
  • BRK
  • BRK
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.97
molecular function
0.95
biological process
0.89
biological term
0.57
gene perturbation
0.56


Related Tools
ProKinO
The ProKinO is a protein kinase-specific ontology, which provides a controlled vocabulary of terms, their hierarchy, and relationships unifying sequence, structure, function, mutation and pathway information on kinases.
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 236.91   (req: < 5)
Gene RIFs: 73   (req: <= 3)
Antibodies: 478   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 236.91   (req: >= 5)
Gene RIFs: 73   (req: > 3)
Antibodies: 478   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 22
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 51
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 2
Approved Drugs (2)
1 – 2 of 2
dasatinib
chemical structure image
ibrutinib
chemical structure image
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
hair shape measurement
1
1
1
74.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
hair shape measurement
1
74.5
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Mouse
MGI:99683
20459
Rat
RGD:1309098
366275
Horse
protein tyrosine kinase 6
VGNC:22004
100060532
Cow
protein tyrosine kinase 6
VGNC:33520
529814
Opossum
protein tyrosine kinase 6
100025045
Species
Name
OMA
EggNOG
Inparanoid
Mouse
Rat
Horse
protein tyrosine kinase 6
Cow
protein tyrosine kinase 6
Opossum
protein tyrosine kinase 6
Protein Structure (8 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q13882-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 5 of 8
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (27)
Cell Cycle (R-HSA-1640170)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 24
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cell Cycle
Reactome
Cell Cycle, Mitotic
Reactome
Cyclin A:Cdk2-associated events at S phase entry
Reactome
Cyclin D associated events in G1
Reactome
Cyclin E associated events during G1/S transition
Name
Explore in Pharos
Explore in Source
Cell Cycle
Cell Cycle, Mitotic
Cyclin A:Cdk2-associated events at S phase entry
Cyclin D associated events in G1
Cyclin E associated events during G1/S transition
Gene Ontology Terms (30)
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Experiment (EXP)
Reactome
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
IntAct
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (83)
1 – 10 of 83
KHDRBS1
Tbio
Novelty: 0.00647929
Score: 0.988
Data Source: Reactome,STRINGDB
STAP2
Tbio
Novelty: 0.00375696
Score: 0.984
Data Source: Reactome,STRINGDB
PXN
Tbio
Novelty: 0.00082031
Score: 0.971
Data Source: Reactome,STRINGDB
STAT3
Tchem
Family: TF
Novelty: 0.00011808
Score: 0.968
Data Source: Reactome,STRINGDB
ARHGAP35
Tbio
Family: Enzyme
Novelty: 0.00970784
Score: 0.967
Data Source: Reactome,STRINGDB
BCAR1
Tbio
Novelty: 0.00329214
Score: 0.964
Data Source: Reactome,STRINGDB
KHDRBS3
Tbio
Novelty: 0.00490069
Score: 0.964
Data Source: Reactome,STRINGDB
EGFR
Tclin
Family: Kinase
Novelty: 0.00007274
Score: 0.953
Data Source: Reactome,STRINGDB
KHDRBS2
Tbio
Novelty: 0.01986638
Score: 0.953
Data Source: Reactome,STRINGDB
ERBB2
Tclin
Family: Kinase
Novelty: 0.00003761
Score: 0.952
Data Source: Reactome,STRINGDB
Publication Statistics
PubMed Score  236.91

PubMed score by year
PubTator Score  94.84

PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer