Pharos: Illuminating the Druggable Genome

Tchem

Protein Classes

Protein Summary

Description

Non-receptor tyrosine-protein kinase implicated in the regulation of a variety of signaling pathways that control the differentiation and maintenance of normal epithelia, as well as tumor growth. Function seems to be context dependent and differ depending on cell type, as well as its intracellular localization. A number of potential nuclear and cytoplasmic substrates have been identified. These include the RNA-binding proteins: KHDRBS1/SAM68, KHDRBS2/SLM1, KHDRBS3/SLM2 and SFPQ/PSF; transcription factors: STAT3 and STAT5A/B and a variety of signaling molecules: ARHGAP35/p190RhoGAP, PXN/paxillin, BTK/ATK, STAP2/BKS. Associates also with a variety of proteins that are likely upstream of PTK6 in various signaling pathways, or for which PTK6 may play an adapter-like role. These proteins include ADAM15, EGFR, ERBB2, ERBB3 and IRS4. In normal or non-tumorigenic tissues, PTK6 promotes cellular differentiation and apoptosis. In tumors PTK6 contributes to cancer progression by sensitizing cells ...more

Uniprot Accession IDs

Gene Name

PTK6

Ensembl ID

ENST00000217185
ENSP00000217185
ENSG00000101213
ENST00000542869
ENSP00000442460

Symbol

Illumination Graph

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
protein domain	0.97

molecular function	0.95

biological process	0.89

biological term	0.57

gene perturbation	0.56

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 191.73 (req: < 5)

View Publications

Gene RIFs: 73 (req: <= 3)

View Gene RIFs

Antibodies: 478 (req: <= 50)

View Antibodies

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 191.73 (req: >= 5)

Gene RIFs: 73 (req: > 3)

Antibodies: 478 (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 22

View GO Terms

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 51

Explore Active Ligands

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 2

Explore Approved Drugs

Approved Drugs (2)

1 – 2 of 2

dasatinib

ibrutinib

Active Ligands (51)

1 – 10 of 51

Protein Data Bank (8)

1 – 5 of 8

PDB Structure Id	Ligand	Method	Resolution (Å)	M.W. (kDa)	Pub Year	Title

PDB Structure Id	M.W.	Resolution	Pub Year

Pathways (27)

Reactome (24)

PathwayCommons (1)

WikiPathways (2)

Cell Cycle (R-HSA-1640170)

Click on a row in the table to change the structure displayed.

Items per page:

1 – 5 of 24

Data Source	Name	Explore in Pharos	Explore in Source
Reactome	Cell Cycle	597 targets	R-HSA-1640170

Reactome	Cell Cycle, Mitotic	495 targets	R-HSA-69278

Reactome	Cyclin A:Cdk2-associated events at S phase entry	86 targets	R-HSA-69656

Reactome	Cyclin D associated events in G1	45 targets	R-HSA-69231

Reactome	Cyclin E associated events during G1/S transition	84 targets	R-HSA-69202

Name	Explore in Pharos	Explore in Source
Cell Cycle	597 targets	R-HSA-1640170

Cell Cycle, Mitotic	495 targets	R-HSA-69278

Cyclin A:Cdk2-associated events at S phase entry	86 targets	R-HSA-69656

Cyclin D associated events in G1	45 targets	R-HSA-69231

Cyclin E associated events during G1/S transition	84 targets	R-HSA-69202

Gene Ontology Terms (30)

Functions (5)

Components (8)

Processes (17)

Items per page:

1 – 5 of 5

GO Term	Evidence	Assigned by
protein tyrosine kinase activity	Inferred from Experiment (EXP)	Reactome

non-membrane spanning protein tyrosine kinase activity	Inferred from Direct Assay (IDA)	UniProtKB

identical protein binding	Inferred from Physical Interaction (IPI)	IntAct

signaling receptor binding	Inferred from Biological aspect of Ancestor (IBA)	GO_Central

ATP binding	Inferred from Electronic Annotation (IEA)	UniProtKB-KW

Protein-Protein Interactions (83)

1 – 10 of 83

See Interactions on String-DB

KHDRBS1

Tbio

Novelty: 0.00737623

Score: 0.988