Protein Summary
Non-receptor tyrosine-protein kinase implicated in the regulation of a variety of signaling pathways that control the differentiation and maintenance of normal epithelia, as well as tumor growth. Function seems to be context dependent and differ depending on cell type, as well as its intracellular localization. A number of potential nuclear and cytoplasmic substrates have been identified. These include the RNA-binding proteins: KHDRBS1/SAM68, KHDRBS2/SLM1, KHDRBS3/SLM2 and SFPQ/PSF; transcription factors: STAT3 and STAT5A/B and a variety of signaling molecules: ARHGAP35/p190RhoGAP, PXN/paxillin, BTK/ATK, STAP2/BKS. Associates also with a variety of proteins that are likely upstream of PTK6 in various signaling pathways, or for which PTK6 may play an adapter-like role. These proteins include ADAM15, EGFR, ERBB2, ERBB3 and IRS4. In normal or non-tumorigenic tissues, PTK6 promotes cellular differentiation and apoptosis. In tumors PTK6 contributes to cancer progression by sensitizing cells ...more
- ENST00000217185
- ENSP00000217185
- ENSG00000101213
- ENST00000542869
- ENSP00000442460
- BRK
- BRK
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
protein domain | 0.97 | ||
molecular function | 0.95 | ||
biological process | 0.89 | ||
biological term | 0.57 | ||
gene perturbation | 0.56 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 240.82 (req: < 5)
Gene RIFs: 73 (req: <= 3)
Antibodies: 478 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 240.82 (req: >= 5)
Gene RIFs: 73 (req: > 3)
Antibodies: 478 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 22
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligands: 60
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drugs: 2
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
Related Tools
The ProKinO is a protein kinase-specific ontology, which provides a controlled vocabulary of terms, their hierarchy, and relationships unifying sequence, structure, function, mutation and pathway information on kinases.
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (2)
Active Ligands (60)
Protein-Protein Interactions (83)
Nearest Tclin Targets
Pathways (27)
Reactome (24)
PathwayCommons (1)
WikiPathways (2)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Cell Cycle | ||||
Reactome | Cell Cycle, Mitotic | ||||
Reactome | Cyclin A:Cdk2-associated events at S phase entry | ||||
Reactome | Cyclin D associated events in G1 | ||||
Reactome | Cyclin E associated events during G1/S transition | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Cell Cycle | ||||
Cell Cycle, Mitotic | ||||
Cyclin A:Cdk2-associated events at S phase entry | ||||
Cyclin D associated events in G1 | ||||
Cyclin E associated events during G1/S transition | ||||
Viral Interactions (0)
Gene Ontology Terms (30)
Functions (5)
Components (8)
Processes (17)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Experiment (EXP) | Reactome | |||
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Physical Interaction (IPI) | IntAct | |||
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Inferred from Electronic Annotation (IEA) | UniProtKB-KW | |||
Disease Associations ()
GWAS Traits (12)
Items per page:
1 – 5 of 12
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
glomerular filtration rate | 2 | 2 | 2 | 70.5 | |||||
electrocardiography | 1 | 2 | 32 | 61.8 | |||||
hair shape measurement | 1 | 1 | 1 | 61 | |||||
daytime rest measurement | 1 | 1 | 1 | 55.2 | |||||
reticulocyte count | 1 | 1 | 1 | 31.4 | |||||
Items per page:
1 – 5 of 12
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
glomerular filtration rate | 2 | 70.5 | |||||
electrocardiography | 32 | 61.8 | |||||
hair shape measurement | 1 | 61 | |||||
daytime rest measurement | 1 | 55.2 | |||||
reticulocyte count | 1 | 31.4 | |||||
Find similar targets by:
IDG Resources
Orthologs (10)
1 – 5 of 10
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Mouse | MGI:99683 | 20459 | ||||||
Rat | RGD:1309098 | 366275 | ||||||
Horse | protein tyrosine kinase 6 | VGNC:22004 | 100060532 | |||||
Cow | protein tyrosine kinase 6 | VGNC:33520 | 529814 | |||||
Opossum | protein tyrosine kinase 6 | 100025045 | ||||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Mouse | ||||||
Rat | ||||||
Horse | protein tyrosine kinase 6 | |||||
Cow | protein tyrosine kinase 6 | |||||
Opossum | protein tyrosine kinase 6 | |||||
Publication Statistics
PubMed Score 240.82
PubMed score by year
PubTator Score 94.84
PubTator score by year
Patents
Patents by year
Related Publications
Text Mined References (101)
GeneRif Annotations (73)
Items per page:
0 of 0
PMID | Year | Title |
|---|