Protein Summary
Non-receptor tyrosine-protein kinase implicated in the regulation of a variety of signaling pathways that control the differentiation and maintenance of normal epithelia, as well as tumor growth. Function seems to be context dependent and differ depending on cell type, as well as its intracellular localization. A number of potential nuclear and cytoplasmic substrates have been identified. These include the RNA-binding proteins: KHDRBS1/SAM68, KHDRBS2/SLM1, KHDRBS3/SLM2 and SFPQ/PSF; transcription factors: STAT3 and STAT5A/B and a variety of signaling molecules: ARHGAP35/p190RhoGAP, PXN/paxillin, BTK/ATK, STAP2/BKS. Associates also with a variety of proteins that are likely upstream of PTK6 in various signaling pathways, or for which PTK6 may play an adapter-like role. These proteins include ADAM15, EGFR, ERBB2, ERBB3 and IRS4. In normal or non-tumorigenic tissues, PTK6 promotes cellular differentiation and apoptosis. In tumors PTK6 contributes to cancer progression by sensitizing cells ...more
- ENST00000217185
- ENSP00000217185
- ENSG00000101213
- ENST00000542869
- ENSP00000442460
- BRK
- BRK
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
---|---|---|---|
protein domain | 0.97 | ||
molecular function | 0.95 | ||
biological process | 0.89 | ||
biological term | 0.57 | ||
gene perturbation | 0.56 | ||
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 191.73 (req: < 5)
Gene RIFs: 73 (req: <= 3)
Antibodies: 478 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 191.73 (req: >= 5)
Gene RIFs: 73 (req: > 3)
Antibodies: 478 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 22
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligands: 51
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drugs: 2
Approved Drugs (2)
1 – 2 of 2
Active Ligands (51)
1 – 10 of 51
Protein Data Bank (8)
1 – 5 of 8
PDB Structure Id | Ligand | Method | Resolution (Ã…) | M.W. (kDa) | Pub Year | Title |
---|
PDB Structure Id | M.W. | Resolution | Pub Year |
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Pathways (27)
Reactome (24)
PathwayCommons (1)
WikiPathways (2)
Click on a row in the table to change the structure displayed.
Items per page:
1 – 5 of 24
Data Source | Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|---|
Reactome | Cell Cycle | ||||
Reactome | Cell Cycle, Mitotic | ||||
Reactome | Cyclin A:Cdk2-associated events at S phase entry | ||||
Reactome | Cyclin D associated events in G1 | ||||
Reactome | Cyclin E associated events during G1/S transition | ||||
Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|
Cell Cycle | ||||
Cell Cycle, Mitotic | ||||
Cyclin A:Cdk2-associated events at S phase entry | ||||
Cyclin D associated events in G1 | ||||
Cyclin E associated events during G1/S transition | ||||
Gene Ontology Terms (30)
Functions (5)
Components (8)
Processes (17)
Items per page:
10
1 – 5 of 5
GO Term | Evidence | Assigned by | ||
---|---|---|---|---|
Inferred from Experiment (EXP) | Reactome | |||
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Physical Interaction (IPI) | IntAct | |||
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Inferred from Electronic Annotation (IEA) | UniProtKB-KW | |||
Protein-Protein Interactions (83)
1 – 10 of 83
KHDRBS1
Novelty: 0.00737623
Score: 0.988
Data Source: Reactome,STRINGDB
STAP2
Novelty: 0.0060675
Score: 0.984
Data Source: Reactome,STRINGDB
PXN
Novelty: 0.00103853
Score: 0.971
Data Source: Reactome,STRINGDB
STAT3
Family: TF
Novelty: 0.00013496
Score: 0.968
Data Source: Reactome,STRINGDB
ARHGAP35
Family: Enzyme
Novelty: 0.01196157
Score: 0.967
Data Source: Reactome,STRINGDB
BCAR1
Novelty: 0.00402253
Score: 0.964
Data Source: Reactome,STRINGDB
KHDRBS3
Novelty: 0.00301036
Score: 0.964
Data Source: Reactome,STRINGDB
EGFR
Family: Kinase
Novelty: 0.0000974
Score: 0.953
Data Source: Reactome,STRINGDB
KHDRBS2
Novelty: 0.04072144
Score: 0.953
Data Source: Reactome,STRINGDB
ERBB2
Family: Kinase
Novelty: 0.00004664
Score: 0.952
Data Source: Reactome,STRINGDB
Publication Statistics
PubMed Score 191.73
PubMed score by year
PubTator Score 94.84
PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
Ortholog Sequence Conservation
PolarG S T Y C
NeutralQ N
BasicK R H
AcidicD E
HydrophobicA V L I P W F M
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UniProt Keyword
GWAS Trait