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Tbio
MOBP
Myelin-associated oligodendrocyte basic protein

Protein Classes
Protein Summary
Description
May play a role in compacting or stabilizing the myelin sheath, possibly by binding the negatively charged acidic phospholipids of the cytoplasmic membrane.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000311042
  • ENSP00000312293
  • ENSG00000168314
  • ENST00000383754
  • ENSP00000373261
  • ENST00000415443
  • ENSP00000388148
  • ENST00000420739
  • ENSP00000400491
  • ENST00000424090
  • ENSP00000389055
  • ENST00000428261
  • ENSP00000401312
  • ENST00000441980
  • ENSP00000388827
  • ENST00000442631
  • ENSP00000413771
  • ENST00000447324
  • ENSP00000409730
  • ENST00000452959
  • ENSP00000405549
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
0.93
disease perturbation
0.74
PubMedID
0.63
gene perturbation
0.58
microRNA
0.55


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 56.58   (req: < 5)
Gene RIFs: 7   (req: <= 3)
Antibodies: 172   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 56.58   (req: >= 5)
Gene RIFs: 7   (req: > 3)
Antibodies: 172   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (3)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
Progressive supranuclear palsy
1
1
0
1.4
83.5
1
1
0
1.1
65.3
sporadic amyotrophic lateral sclerosis
1
1
1
38.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
Progressive supranuclear palsy
0
1.4
83.5
0
1.1
65.3
sporadic amyotrophic lateral sclerosis
1
38.1
Orthologs (5)
1 – 5 of 5
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
myelin-associated oligodendrocyte basic protein
717265
Mouse
MGI:108511
17433
Rat
RGD:3101
25037
Horse
myelin-associated oligodendrocyte basic protein
VGNC:20252
100068147
Pig
myelin-associated oligodendrocyte basic protein
100152154
Species
Name
OMA
EggNOG
Inparanoid
Macaque
myelin-associated oligodendrocyte basic protein
Mouse
Rat
Horse
myelin-associated oligodendrocyte basic protein
Pig
myelin-associated oligodendrocyte basic protein
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q13875-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (4)
Gene expression (Transcription) (R-HSA-74160)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Gene expression (Transcription)
Reactome
Generic Transcription Pathway
Reactome
RNA Polymerase II Transcription
Reactome
Transcriptional Regulation by MECP2
Name
Explore in Pharos
Explore in Source
Gene expression (Transcription)
Generic Transcription Pathway
RNA Polymerase II Transcription
Transcriptional Regulation by MECP2
Gene Ontology Terms (9)
Items per page:
10
1 – 4 of 4
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Electronic Annotation (IEA)
Ensembl
Protein-Protein Interactions (42)
1 – 10 of 42
MOG
Tbio
Novelty: 0.00048664
Score: 0.8
Data Source: STRINGDB
OPALIN
Tdark
Novelty: 0.08221612
Score: 0.773
Data Source: STRINGDB
PLP1
Tbio
Novelty: 0.00129083
Score: 0.727
Data Source: STRINGDB
ERMN
Tbio
Novelty: 0.05302803
Score: 0.702
Data Source: STRINGDB
MAG
Tchem
Novelty: 0.00085621
Score: 0.702
Data Source: STRINGDB
MBP
Tbio
Novelty: 0.00016333
Score: 0.675
Data Source: STRINGDB
GFAP
Tbio
Novelty: 0.00020932
Score: 0.618
Data Source: STRINGDB
CLDN11
Tbio
Novelty: 0.00275436
Score: 0.616
Data Source: STRINGDB
OLIG2
Tbio
Family: TF
Novelty: 0.0015221
Score: 0.593
Data Source: STRINGDB
OLIG1
Tbio
Family: TF
Novelty: 0.01006324
Score: 0.563
Data Source: STRINGDB
Publication Statistics
PubMed Score  56.58

PubMed score by year
PubTator Score  15.44

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer