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Tbio
BLMH
Bleomycin hydrolase

Protein Summary
Description
The normal physiological role of BLM hydrolase is unknown, but it catalyzes the inactivation of the antitumor drug BLM (a glycopeptide) by hydrolyzing the carboxamide bond of its B-aminoalaninamide moiety thus protecting normal and malignant cells from BLM toxicity. Bleomycin hydrolase (BMH) is a cytoplasmic cysteine peptidase that is highly conserved through evolution; however, the only known activity of the enzyme is metabolic inactivation of the glycopeptide bleomycin (BLM), an essential component of combination chemotherapy regimens for cancer. The protein contains the signature active site residues of the cysteine protease papain superfamily. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000261714
  • ENSP00000261714
  • ENSG00000108578

Symbol
  • BH
  • BMH
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
0.97
transcription factor perturbation
0.94
kinase perturbation
0.91
histone modification site profile
0.82
cell type or tissue
0.71


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 114.52   (req: < 5)
Gene RIFs: 18   (req: <= 3)
Antibodies: 242   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 114.52   (req: >= 5)
Gene RIFs: 18   (req: > 3)
Antibodies: 242   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (63)
NUDT12
Tbio
Family:  Enzyme
Novelty:  0.18740719
p_int:  0.999999986
p_ni:  1.4e-8
Score:  0.869
Data Source:  BioPlex,STRINGDB
KERA
Tbio
Novelty:  0.00789599
p_int:  0.990459728
p_ni:  0.009540272
Score:  0.874
Data Source:  BioPlex,STRINGDB
PGLS
Tbio
Family:  Enzyme
Novelty:  0.03252394
Score:  0.802
Data Source:  STRINGDB
WDR73
Tbio
Novelty:  0.10253438
Score:  0.687
Data Source:  STRINGDB
CASP14
Tchem
Family:  Enzyme
Novelty:  0.01230567
Score:  0.675
Data Source:  STRINGDB
TAPBPL
Tbio
Novelty:  0.06343547
Score:  0.651
Data Source:  STRINGDB
SMC3
Tbio
Novelty:  0.00474377
Score:  0.606
Data Source:  STRINGDB
NPEPPS
Tchem
Family:  Enzyme
Novelty:  0.01214136
Score:  0.588
Data Source:  STRINGDB
LTA4H
Tchem
Family:  Enzyme
Novelty:  0.00505614
Score:  0.58
Data Source:  STRINGDB
MORF4L1
Tbio
Family:  Epigenetic
Novelty:  0.01696001
Score:  0.572
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (4)
Adaptive Immune System (R-HSA-1280218)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Adaptive Immune System
Reactome
Antigen processing: Ubiquitination & Proteasome degradation
Reactome
Class I MHC mediated antigen processing & presentation
Reactome
Immune System
Name
Explore in Pharos
Explore in Source
Adaptive Immune System
Antigen processing: Ubiquitination & Proteasome degradation
Class I MHC mediated antigen processing & presentation
Immune System
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (14)
Find Similar Targets
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Experiment (EXP)
Reactome
Inferred from Physical Interaction (IPI)
IntAct
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Traceable Author Statement (TAS)
ProtInc
Traceable Author Statement (TAS)
ProtInc
Disease Associations (null)
No disease associations found
GWAS Traits (9)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
sex hormone-binding globulin measurement
2
1
2
56.8
total cholesterol measurement
1
2
2
39.5
visceral adipose tissue measurement
1
1
1
33.1
QRS complex
1
1
0
115.6
28.1
QRS amplitude
1
1
0
115.6
28.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
sex hormone-binding globulin measurement
2
56.8
total cholesterol measurement
2
39.5
visceral adipose tissue measurement
1
33.1
QRS complex
0
115.6
28.1
QRS amplitude
0
115.6
28.1
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
bleomycin hydrolase
VGNC:9147
454555
Macaque
bleomycin hydrolase
712275
Mouse
MGI:1345186
104184
Rat
RGD:1304668
287552
Dog
bleomycin hydrolase
VGNC:38465
480635
Species
Name
OMA
EggNOG
Inparanoid
Chimp
bleomycin hydrolase
Macaque
bleomycin hydrolase
Mouse
Rat
Dog
bleomycin hydrolase
Publication Statistics
PubMed Score 114.52
PubMed score by year
PubTator Score 68.57
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title