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Tbio
DDX39B
Spliceosome RNA helicase DDX39B

Protein Summary
Description
Involved in nuclear export of spliced and unspliced mRNA. Assembling component of the TREX complex which is thought to couple mRNA transcription, processing and nuclear export, and specifically associates with spliced mRNA and not with unspliced pre-mRNA. TREX is recruited to spliced mRNAs by a transcription-independent mechanism, binds to mRNA upstream of the exon-junction complex (EJC) and is recruited in a splicing- and cap-dependent manner to a region near the 5' end of the mRNA where it functions in mRNA export to the cytoplasm via the TAP/NFX1 pathway. May undergo several rounds of ATP hydrolysis during assembly of TREX to drive subsequent loading of components such as ALYREF/THOC and CHTOP onto mRNA. The TREX complex is essential for the export of Kaposi's sarcoma-associated herpesvirus (KSHV) intronless mRNAs and infectious virus production. Also associates with pre-mRNA independent of ALYREF/THOC4 and the THO complex. Involved in the nuclear export of intronless mRNA; the ATP- ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000383508
  • ENSP00000373000
  • ENSG00000215425
  • ENST00000396172
  • ENSP00000379475
  • ENSG00000198563
  • ENST00000400295
  • ENSP00000383151
  • ENST00000400296
  • ENSP00000383152
  • ENST00000412106
  • ENSP00000393712
  • ENSG00000225073
  • ENST00000412330
  • ENSP00000398775
  • ENSG00000225859
  • ENST00000413678
  • ENSP00000391463
  • ENSG00000229496
  • ENST00000414440
  • ENSP00000411853
  • ENST00000415689
  • ENSP00000390999
  • ENST00000416863
  • ENSP00000407419
  • ENST00000430784
  • ENSP00000399030
  • ENSG00000235439
  • ENST00000431360
  • ENSP00000404695
  • ENST00000441425
  • ENSP00000388880
  • ENSG00000230624
  • ENST00000445218
  • ENSP00000411136
  • ENST00000448296
  • ENSP00000405560
  • ENST00000453138
  • ENSP00000387994
  • ENST00000456476
  • ENSP00000400326
  • ENST00000456666
  • ENSP00000394160
  • ENST00000458640
  • ENSP00000416269

Symbol
  • BAT1
  • UAP56
  • BAT1
  • UAP56
  • D6S81E
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
interacting protein
1
molecular function
1
small molecule perturbation
0.99
transcription factor binding site profile
0.88
phenotype
0.86


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 94.29   (req: < 5)
Gene RIFs: 37   (req: <= 3)
Antibodies: 287   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 94.29   (req: >= 5)
Gene RIFs: 37   (req: > 3)
Antibodies: 287   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 25
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (421)
RBM8A
Tbio
Novelty:  0.00052175
Score:  0.999
Data Source:  STRINGDB
CHTOP
Tbio
Novelty:  0.04170391
Score:  0.999
Data Source:  STRINGDB
MAGOH
Tbio
Novelty:  0.03637008
Score:  0.999
Data Source:  STRINGDB
ALYREF
Tbio
Novelty:  0.00523802
Score:  0.999
Data Source:  STRINGDB
THOC2
Tbio
Novelty:  0.02886456
Score:  0.999
Data Source:  STRINGDB
SRSF3
Tbio
Novelty:  0.01015895
Score:  0.998
Data Source:  STRINGDB
THOC1
Tbio
Novelty:  0.03702557
Score:  0.998
Data Source:  STRINGDB
THOC5
Tbio
Novelty:  0.04618391
Score:  0.998
Data Source:  STRINGDB
THOC3
Tbio
Novelty:  0.04716962
Score:  0.998
Data Source:  STRINGDB
U2AF2
Tbio
Novelty:  0.00590935
Score:  0.998
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (11)
Gene expression (Transcription) (R-HSA-74160)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 8
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Gene expression (Transcription)
Reactome
Metabolism of RNA
Reactome
Processing of Capped Intron-Containing Pre-mRNA
Reactome
RNA Polymerase II Transcription
Reactome
RNA Polymerase II Transcription Termination
Name
Explore in Pharos
Explore in Source
Gene expression (Transcription)
Metabolism of RNA
Processing of Capped Intron-Containing Pre-mRNA
RNA Polymerase II Transcription
RNA Polymerase II Transcription Termination
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (32)
Find Similar Targets
Items per page:
10
1 – 10 of 10
GO Term
Evidence
Assigned by
Inferred from Experiment (EXP)
Reactome
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Physical Interaction (IPI)
IntAct
Inferred from High Throughput Direct Assay (HDA)
UniProtKB
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
Ensembl
Disease Associations ()
No disease associations found
GWAS Traits (847)
Items per page:
1 – 5 of 847
GWAS Trait
EFO ID
ENSG ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
lymphocyte count
3
5
7
98.6
lymphocyte count
3
5
7
98.6
lymphocyte count
3
5
7
98.6
lymphocyte count
3
5
7
98.6
lymphocyte count
3
5
7
98.6
Items per page:
1 – 5 of 847
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
lymphocyte count
7
98.6
lymphocyte count
7
98.6
lymphocyte count
7
98.6
lymphocyte count
7
98.6
lymphocyte count
7
98.6
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
DExD-box helicase 39B
VGNC:52006
463180
Macaque
DExD-box helicase 39B
715233
Mouse
MGI:99240
53817
Rat
RGD:70923
114612
Dog
DExD-box helicase 39B
VGNC:39855
474839
Species
Name
OMA
EggNOG
Inparanoid
Chimp
DExD-box helicase 39B
Macaque
DExD-box helicase 39B
Mouse
Rat
Dog
DExD-box helicase 39B
Publication Statistics
PubMed Score 94.29
PubMed score by year
PubTator Score 58.00
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title