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Tbio
AUH
Methylglutaconyl-CoA hydratase, mitochondrial

Protein Classes
Protein Summary
Description
Catalyzes the conversion of 3-methylglutaconyl-CoA to 3-hydroxy-3-methylglutaryl-CoA (PubMed:11738050, PubMed:12434311, PubMed:12655555). Also has itaconyl-CoA hydratase activity by converting itaconyl-CoA into citramalyl-CoA in the C5-dicarboxylate catabolism pathway (PubMed:29056341). The C5-dicarboxylate catabolism pathway is required to detoxify itaconate, a vitamin B12-poisoning metabolite (PubMed:29056341). Has very low enoyl-CoA hydratase activity (PubMed:7892223). Was originally identified as RNA-binding protein that binds in vitro to clustered 5'-AUUUA-3' motifs (PubMed:7892223). This gene encodes bifunctional mitochondrial protein that has both RNA-binding and hydratase activities. The encoded protein is a methylglutaconyl-CoA hydratase that catalyzes the hydration of 3-methylglutaconyl-CoA to 3-hydroxy-3-methyl-glutaryl-CoA, a critical step in the leucine degradation pathway. This protein also binds AU-rich elements (AREs) found in the 3' UTRs of rapidly decaying mRNAs inclu ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000303617
  • ENSP00000307334
  • ENSG00000148090
  • ENST00000375731
  • ENSP00000364883
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor perturbation
0.96
disease perturbation
0.93
virus perturbation
0.88
kinase perturbation
0.84
cell type or tissue
0.79


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 104.8   (req: < 5)
Gene RIFs: 8   (req: <= 3)
Antibodies: 134   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 104.8   (req: >= 5)
Gene RIFs: 8   (req: > 3)
Antibodies: 134   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Data Bank (3)
1 – 3 of 3
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (16)
Branched-chain amino acid catabolism (R-HSA-70895)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Branched-chain amino acid catabolism
Reactome
Metabolism
Reactome
Metabolism of amino acids and derivatives
Name
Explore in Pharos
Explore in Source
Branched-chain amino acid catabolism
Metabolism
Metabolism of amino acids and derivatives
Protein-Protein Interactions (66)
1 – 10 of 66
ECHDC2
Tdark
Family: Enzyme
Novelty: 0.50139276
p_int: 0.999999999
p_ni: 1e-9
Score: 0.276
Data Source: BioPlex,STRINGDB
HINT2
Tbio
Novelty: 0.0404157
p_int: 0.999964835
p_ni: 0.000033797
p_wrong: 0.000001367
Data Source: BioPlex
ATP5F1D
Tbio
Family: Enzyme
Novelty: 0.10560736
p_int: 0.999497627
p_ni: 0.000257201
p_wrong: 0.000245172
Score: 0.261
Data Source: BioPlex,STRINGDB
OXLD1
Tdark
Family: Enzyme
p_int: 0.999473517
p_ni: 0.000259158
p_wrong: 0.000267326
Score: 0.183
Data Source: BioPlex,STRINGDB
MRPL21
Tdark
Novelty: 1.72292191
p_int: 0.994685451
p_ni: 0.000047031
p_wrong: 0.005267517
Score: 0.208
Data Source: BioPlex,STRINGDB
BPNT1
Tbio
Family: Enzyme
Novelty: 0.13729977
p_int: 0.933512601
p_ni: 0.000760558
p_wrong: 0.065726841
Data Source: BioPlex
MCCC2
Tbio
Family: Enzyme
Novelty: 0.09899823
Score: 0.963
Data Source: STRINGDB
HMGCLL1
Tbio
Family: Enzyme
Novelty: 0.13100437
Score: 0.959
Data Source: STRINGDB
HMGCL
Tbio
Family: Enzyme
Novelty: 0.03613197
Score: 0.958
Data Source: STRINGDB
HMGCS2
Tbio
Family: Enzyme
Novelty: 0.01524028
Score: 0.94
Data Source: STRINGDB
Publication Statistics
PubMed Score  104.80

PubMed score by year
PubTator Score  69.91

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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