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Tchem
ENPP2
Ectonucleotide pyrophosphatase/phosphodiesterase family member 2

Protein Summary
Description
Hydrolyzes lysophospholipids to produce the signaling molecule lysophosphatidic acid (LPA) in extracellular fluids (PubMed:15769751, PubMed:26371182, PubMed:27754931). Major substrate is lysophosphatidylcholine (PubMed:12176993, PubMed:27754931). Also can act on sphingosylphosphorylcholine producing sphingosine-1-phosphate, a modulator of cell motility. Can hydrolyze, in vitro, bis-pNPP, to some extent pNP-TMP, and barely ATP (PubMed:15769751, PubMed:12176993). Involved in several motility-related processes such as angiogenesis and neurite outgrowth. Acts as an angiogenic factor by stimulating migration of smooth muscle cells and microtubule formation (PubMed:11559573). Stimulates migration of melanoma cells, probably via a pertussis toxin-sensitive G protein (PubMed:1733949). May have a role in induction of parturition (PubMed:12176993). Possible involvement in cell proliferation and adipose tissue development (Probable). Tumor cell motility-stimulating factor (PubMed:1733949, PubMed: ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000075322
  • ENSP00000075322
  • ENSG00000136960
  • ENST00000259486
  • ENSP00000259486
  • ENST00000522826
  • ENSP00000428291

Symbol
  • ATX
  • PDNP2
  • ATX
  • NPP2
  • ATX-X
  • PDNP2
  • LysoPLD
  • AUTOTAXIN
  • PD-IALPHA
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.99
gene perturbation
0.98
molecular function
0.98
transcription factor perturbation
0.94
small molecule perturbation
0.86


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 734.8   (req: < 5)
Gene RIFs: 168   (req: <= 3)
Antibodies: 428   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 734.8   (req: >= 5)
Gene RIFs: 168   (req: > 3)
Antibodies: 428   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 21
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 535
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 1