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Tchem
ENPP2
Ectonucleotide pyrophosphatase/phosphodiesterase family member 2

Protein Summary
Description
Hydrolyzes lysophospholipids to produce the signaling molecule lysophosphatidic acid (LPA) in extracellular fluids (PubMed:15769751, PubMed:26371182, PubMed:27754931). Major substrate is lysophosphatidylcholine (PubMed:12176993, PubMed:27754931). Also can act on sphingosylphosphorylcholine producing sphingosine-1-phosphate, a modulator of cell motility. Can hydrolyze, in vitro, bis-pNPP, to some extent pNP-TMP, and barely ATP (PubMed:15769751, PubMed:12176993). Involved in several motility-related processes such as angiogenesis and neurite outgrowth. Acts as an angiogenic factor by stimulating migration of smooth muscle cells and microtubule formation (PubMed:11559573). Stimulates migration of melanoma cells, probably via a pertussis toxin-sensitive G protein (PubMed:1733949). May have a role in induction of parturition (PubMed:12176993). Possible involvement in cell proliferation and adipose tissue development (Probable). Tumor cell motility-stimulating factor (PubMed:1733949, PubMed: ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000075322
  • ENSP00000075322
  • ENSG00000136960
  • ENST00000259486
  • ENSP00000259486
  • ENST00000522826
  • ENSP00000428291

Symbol
  • ATX
  • PDNP2
  • ATX
  • NPP2
  • ATX-X
  • PDNP2
  • LysoPLD
  • AUTOTAXIN
  • PD-IALPHA
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.99
gene perturbation
0.98
molecular function
0.98
transcription factor perturbation
0.94
small molecule perturbation
0.86


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 645.93   (req: < 5)
Gene RIFs: 128   (req: <= 3)
Antibodies: 428   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 645.93   (req: >= 5)
Gene RIFs: 128   (req: > 3)
Antibodies: 428   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 21
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 220
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 1
Approved Drugs (1)
1 – 1 of 1
evans blue
chemical structure image
GWAS Traits (3)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
appendicular lean mass
4
1
4
95.1
cortical surface area measurement
1
1
0
64.9
88.4
birth weight
1
1
1
45.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
appendicular lean mass
4
95.1
cortical surface area measurement
0
64.9
88.4
birth weight
1
45.6
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
ectonucleotide pyrophosphatase/phosphodiesterase 2
VGNC:1170
464353
Macaque
ectonucleotide pyrophosphatase/phosphodiesterase 2
705287
Mouse
MGI:1321390
18606
Rat
RGD:69298
84050
Dog
ectonucleotide pyrophosphatase/phosphodiesterase 2
VGNC:40375
482026
Species
Name
OMA
EggNOG
Inparanoid
Chimp
ectonucleotide pyrophosphatase/phosphodiesterase 2
Macaque
ectonucleotide pyrophosphatase/phosphodiesterase 2
Mouse
Rat
Dog
ectonucleotide pyrophosphatase/phosphodiesterase 2
Protein Data Bank (7)
1 – 5 of 7
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (9)
HuR (ELAVL1) binds and stabilizes mRNA (R-HSA-450520)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 7
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
HuR (ELAVL1) binds and stabilizes mRNA
Reactome
Metabolism
Reactome
Metabolism of RNA
Reactome
Metabolism of vitamins and cofactors
Reactome
Metabolism of water-soluble vitamins and cofactors
Name
Explore in Pharos
Explore in Source
HuR (ELAVL1) binds and stabilizes mRNA
Metabolism
Metabolism of RNA
Metabolism of vitamins and cofactors
Metabolism of water-soluble vitamins and cofactors
Gene Ontology Terms (23)
Items per page:
10
1 – 10 of 11
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Traceable Author Statement (TAS)
UniProtKB
Traceable Author Statement (TAS)
ProtInc
Inferred from Electronic Annotation (IEA)
InterPro
Inferred from Electronic Annotation (IEA)
InterPro
Inferred from Electronic Annotation (IEA)
InterPro
Protein-Protein Interactions (74)
1 – 10 of 74
ENPP6
Tbio
Family: Enzyme
Novelty: 0.06933544
Score: 0.928
Data Source: STRINGDB
LPAR1
Tchem
Family: GPCR
Novelty: 0.00318056
Score: 0.914
Data Source: STRINGDB
LPCAT4
Tdark
Family: Enzyme
Novelty: 0.246654
Score: 0.902
Data Source: STRINGDB
TMEM86B
Tbio
Family: Enzyme
Novelty: 0.26982157
Score: 0.9
Data Source: STRINGDB
GDPD1
Tbio
Family: Enzyme
Novelty: 0.28722153
Score: 0.876
Data Source: STRINGDB
GDPD3
Tbio
Family: Enzyme
Novelty: 0.18121762
Score: 0.848
Data Source: STRINGDB
LPAR2
Tchem
Family: GPCR
Novelty: 0.00794134
Score: 0.809
Data Source: STRINGDB
LPAR3
Tchem
Family: GPCR
Novelty: 0.00590837
Score: 0.808
Data Source: STRINGDB
PLA2G1B
Tchem
Family: Enzyme
Novelty: 0.00064842
Score: 0.791
Data Source: STRINGDB
PLA2G10
Tchem
Family: Enzyme
Novelty: 0.00289317
Score: 0.788
Data Source: STRINGDB
Publication Statistics
PubMed Score  645.93

PubMed score by year
PubTator Score  422.09

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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