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Tbio
SPTAN1
Spectrin alpha chain, non-erythrocytic 1

Protein Summary
Description
Fodrin, which seems to be involved in secretion, interacts with calmodulin in a calcium-dependent manner and is thus candidate for the calcium-dependent movement of the cytoskeleton at the membrane. Spectrins are a family of filamentous cytoskeletal proteins that function as essential scaffold proteins that stabilize the plasma membrane and organize intracellular organelles. Spectrins are composed of alpha and beta dimers that associate to form tetramers linked in a head-to-head arrangement. This gene encodes an alpha spectrin that is specifically expressed in nonerythrocytic cells. The encoded protein has been implicated in other cellular functions including DNA repair and cell cycle regulation. Mutations in this gene are the cause of early infantile epileptic encephalopathy-5. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Sep 2010]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000358161
  • ENSP00000350882
  • ENSG00000197694
  • ENST00000372731
  • ENSP00000361816
  • ENST00000372739
  • ENSP00000361824

Symbol
  • NEAS
  • SPTA2
  • NEAS
  • EIEE5
  • SPTA2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
hub protein
1
interacting protein
1
protein domain
0.97
kinase perturbation
0.96
transcription factor perturbation
0.91


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 356.54   (req: < 5)
Gene RIFs: 32   (req: <= 3)
Antibodies: 427   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 356.54   (req: >= 5)
Gene RIFs: 32   (req: > 3)
Antibodies: 427   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 11
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
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GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (355)
SPTBN1
Tbio
Novelty:  0.01490638
Score:  0.999
Data Source:  STRINGDB
SPTBN5
Tbio
Novelty:  0.18740061
Score:  0.987
Data Source:  STRINGDB
CDC5L
Tbio
Family:  TF
Novelty:  0.00663599
Score:  0.98
Data Source:  STRINGDB
SPTBN2
Tbio
Novelty:  0.01183066
Score:  0.975
Data Source:  STRINGDB
CASP3
Tchem
Family:  Enzyme
Novelty:  0.00003555
Score:  0.972
Data Source:  Reactome,STRINGDB
CAPN1
Tchem
Novelty:  0.00252811
Score:  0.97
Data Source:  STRINGDB
ANK2
Tbio
Novelty:  0.00528351
Score:  0.969
Data Source:  Reactome,STRINGDB
ANK1
Tbio
Novelty:  0.00225305
Score:  0.964
Data Source:  Reactome,STRINGDB
ANK3
Tbio
Novelty:  0.00429246
Score:  0.961
Data Source:  STRINGDB
SPTBN4
Tbio
Novelty:  0.02182293
Score:  0.955
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (80)
Apoptosis (R-HSA-109581)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 31
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Apoptosis
Reactome
Apoptotic cleavage of cellular proteins
Reactome
Apoptotic execution phase
Reactome
Asparagine N-linked glycosylation
Reactome
Axon guidance
Name
Explore in Pharos
Explore in Source
Apoptosis
Apoptotic cleavage of cellular proteins
Apoptotic execution phase
Asparagine N-linked glycosylation
Axon guidance
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (21)
Find Similar Targets
Items per page:
10
1 – 6 of 6
GO Term
Evidence
Assigned by
Inferred from High Throughput Direct Assay (HDA)
BHF-UCL
Traceable Author Statement (TAS)
ProtInc
Traceable Author Statement (TAS)
Reactome
Traceable Author Statement (TAS)
ProtInc
Inferred from Electronic Annotation (IEA)
InterPro
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Disease Associations ()
No disease associations found
GWAS Traits (11)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
platelet crit
2
2
2
89.4
sex hormone-binding globulin measurement
6
1
6
83.3
platelet count
1
1
1
71.6
myeloid white cell count
1
1
1
70.2
neutrophil count
2
1
2
70.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
platelet crit
2
89.4
sex hormone-binding globulin measurement
6
83.3
platelet count
1
71.6
myeloid white cell count
1
70.2
neutrophil count
2
70.2
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
spectrin alpha, non-erythrocytic 1
VGNC:10107
464771
Macaque
spectrin alpha, non-erythrocytic 1
722610
Mouse
MGI:98386
20740
Rat
RGD:621714
64159
Dog
spectrin alpha, non-erythrocytic 1
VGNC:46773
403484
Species
Name
OMA
EggNOG
Inparanoid
Chimp
spectrin alpha, non-erythrocytic 1
Macaque
spectrin alpha, non-erythrocytic 1
Mouse
Rat
Dog
spectrin alpha, non-erythrocytic 1
Publication Statistics
PubMed Score 356.54
PubMed score by year
PubTator Score 153.82
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title