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Tbio
ITGA9
Integrin alpha-9

Protein Summary
Description
Integrin alpha-9/beta-1 (ITGA9:ITGB1) is a receptor for VCAM1, cytotactin and osteopontin. It recognizes the sequence A-E-I-D-G-I-E-L in cytotactin. This gene encodes an alpha integrin. Integrins are heterodimeric integral membrane glycoproteins composed of an alpha chain and a beta chain that mediate cell-cell and cell-matrix adhesion. The protein encoded by this gene, when bound to the beta 1 chain, forms an integrin that is a receptor for VCAM1, cytotactin and osteopontin. Expression of this gene has been found to be upregulated in small cell lung cancers. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000264741
  • ENSP00000264741
  • ENSG00000144668

Symbol
  • RLC
  • ITGA4L
  • ALPHA-RLC
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
PubMedID
0.88
transcription factor perturbation
0.8
protein domain
0.73
protein complex
0.69
phenotype
0.67


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 67.8   (req: < 5)
Gene RIFs: 42   (req: <= 3)
Antibodies: 185   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 67.8   (req: >= 5)
Gene RIFs: 42   (req: > 3)
Antibodies: 185   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (156)
ALDH1A3
Tchem
Family:  Enzyme
Novelty:  0.00691116
p_int:  0.99962957
p_ni:  0.000192771
p_wrong:  0.000177659
Score:  0.189
Data Source:  BioPlex,STRINGDB
LCN2
Tbio
Family:  Enzyme
Novelty:  0.00034678
p_int:  0.999211206
p_ni:  0.0007887
p_wrong:  9.4e-8
Score:  0.194
Data Source:  BioPlex,STRINGDB
SERPINB4
Tbio
Novelty:  0.00522283
p_int:  0.997425268
p_ni:  0.002574732
Data Source:  BioPlex
SPRR1B
Tbio
Novelty:  0.0320028
p_int:  0.996577108
p_ni:  0.00062981
p_wrong:  0.002793082
Score:  0.435
Data Source:  BioPlex,STRINGDB
ITGB1
Tclin
Novelty:  0.00055626
p_int:  0.994906846
p_ni:  0.005093154
Score:  0.989
Data Source:  BioPlex,Reactome,STRINGDB
PCYOX1L
Tdark
Family:  Enzyme
Novelty:  1.25398886
p_int:  0.987162391
p_ni:  0.012834787
p_wrong:  0.000002822
Score:  0.189
Data Source:  BioPlex,STRINGDB
SMOC1
Tbio
Novelty:  0.03819681
p_int:  0.960778822
p_ni:  0.038428963
p_wrong:  0.000792215
Data Source:  BioPlex
IGLL5
Tbio
Novelty:  0.00459259
p_int:  0.942185816
p_ni:  0.002189026
p_wrong:  0.055625158
Score:  0.186
Data Source:  BioPlex,STRINGDB
KLK10
Tbio
Family:  Enzyme
Novelty:  0.00899521
p_int:  0.935142332
p_ni:  0.021802781
p_wrong:  0.043054887
Score:  0.192
Data Source:  BioPlex,STRINGDB
IVL
Tbio
Novelty:  0.00147892
p_int:  0.933122527
p_ni:  0.066877473
Score:  0.217
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets (11)
Explore Nearest Tclin Targets
1 – 5 of 5
ITGA2B
Tclin
Family:  Other
KEGG Distance:  1
Common Pathways:  8
more:  4 more common pathways
ITGB3
Tclin
Family:  Other
KEGG Distance:  1
Common Pathways:  8
more:  4 more common pathways
ITGA4
Tclin
Family:  Other
KEGG Distance:  1
Common Pathways:  9
more:  5 more common pathways
ITGB7
Tclin
Family:  Other
KEGG Distance:  1
Common Pathways:  9
more:  5 more common pathways
ITGB1
Tclin
Family:  Other
KEGG Distance:  1
Common Pathways:  9
more:  5 more common pathways
Pathways (29)
Axon guidance (R-HSA-422475)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 7
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Axon guidance
Reactome
Developmental Biology
Reactome
ECM proteoglycans
Reactome
Extracellular matrix organization
Reactome
Integrin cell surface interactions
Name
Explore in Pharos
Explore in Source
Axon guidance
Developmental Biology
ECM proteoglycans
Extracellular matrix organization
Integrin cell surface interactions
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (12)
Find Similar Targets
Items per page:
10
1 – 3 of 3
GO Term
Evidence
Assigned by
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Disease Associations (null)
No disease associations found
GWAS Traits (14)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
red blood cell density measurement
1
1
1
79.4
pulse pressure measurement
1
1
1
62.6
waist-hip ratio
1
1
1
59
BMI-adjusted waist-hip ratio
2
1
2
56.6
lymphocyte count
1
1
1
48.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
red blood cell density measurement
1
79.4
pulse pressure measurement
1
62.6
waist-hip ratio
1
59
BMI-adjusted waist-hip ratio
2
56.6
lymphocyte count
1
48.5
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (8)
1 – 5 of 8
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
integrin subunit alpha 9 [Source:HGNC Symbol;Acc:HGNC:6145]
Mouse
MGI:104756
104099
Rat
RGD:1311191
685004
Dog
integrin subunit alpha 9
VGNC:49914
477021
Horse
integrin subunit alpha 9 [Source:HGNC Symbol;Acc:HGNC:6145]
Species
Name
OMA
EggNOG
Inparanoid
Macaque
integrin subunit alpha 9 [Source:HGNC Symbol;Acc:HGNC:6145]
Mouse
Rat
Dog
integrin subunit alpha 9
Horse
integrin subunit alpha 9 [Source:HGNC Symbol;Acc:HGNC:6145]
Publication Statistics
PubMed Score 67.80
PubMed score by year
PubTator Score 99.81
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title