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Tbio
PMAIP1
Phorbol-12-myristate-13-acetate-induced protein 1

Protein Summary
Description
Promotes activation of caspases and apoptosis. Promotes mitochondrial membrane changes and efflux of apoptogenic proteins from the mitochondria. Contributes to p53/TP53-dependent apoptosis after radiation exposure. Promotes proteasomal degradation of MCL1. Competes with BAK1 for binding to MCL1 and can displace BAK1 from its binding site on MCL1 (By similarity). Competes with BIM/BCL2L11 for binding to MCL1 and can displace BIM/BCL2L11 from its binding site on MCL1.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000269518
  • ENSP00000269518
  • ENSG00000141682
  • ENST00000316660
  • ENSP00000326119

Symbol
  • NOXA
  • APR
  • NOXA
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0.99
PubMedID
0.99
small molecule perturbation
0.99
virus perturbation
0.99
transcription factor perturbation
0.91


Related Tools
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 447.96   (req: < 5)
Gene RIFs: 96   (req: <= 3)
Antibodies: 433   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 447.96   (req: >= 5)
Gene RIFs: 96   (req: > 3)
Antibodies: 433   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 27
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (1)
1 – 1 of 1
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Dog
phorbol-12-myristate-13-acetate-induced protein 1
VGNC:53752
100502558
Species
Name
OMA
EggNOG
Inparanoid
Dog
phorbol-12-myristate-13-acetate-induced protein 1
Protein Data Bank (1)
1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (32)
Activation of BH3-only proteins (R-HSA-114452)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 12
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Activation of BH3-only proteins
Reactome
Activation of NOXA and translocation to mitochondria
Reactome
Apoptosis
Reactome
BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members
Reactome
Gene expression (Transcription)
Name
Explore in Pharos
Explore in Source
Activation of BH3-only proteins
Activation of NOXA and translocation to mitochondria
Apoptosis
BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members
Gene expression (Transcription)
Gene Ontology Terms (31)
Items per page:
10
1 – 4 of 4
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Traceable Author Statement (TAS)
Reactome
Protein-Protein Interactions (118)
1 – 10 of 118
BCL2L1
Tchem
Novelty: 0.00018414
Score: 0.996
Data Source: STRINGDB
MCL1
Tchem
Novelty: 0.00046181
Score: 0.993
Data Source: STRINGDB
TP53
Tchem
Family: TF
Novelty: 0.00001907
Score: 0.988
Data Source: STRINGDB
BCL2L11
Tbio
Novelty: 0.00055914
Score: 0.983
Data Source: STRINGDB
BCL2
Tclin
Novelty: 0.00608635
Score: 0.977
Data Source: STRINGDB
BCL2A1
Tchem
Novelty: 0.00088899
Score: 0.976
Data Source: STRINGDB
BBC3
Tbio
Novelty: 0.00773944
Score: 0.972
Data Source: STRINGDB
BBC3
Tbio
Novelty: 0.00773944
Score: 0.972
Data Source: STRINGDB
BID
Tbio
Novelty: 0.01264688
Score: 0.951
Data Source: STRINGDB
BCL2L2
Tchem
Novelty: 0.00430896
Score: 0.935
Data Source: STRINGDB
Publication Statistics
PubMed Score  447.96

PubMed score by year
PubTator Score  810.57

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer