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Tbio
THOC5
THO complex subunit 5 homolog

Protein Summary
Description
Acts as component of the THO subcomplex of the TREX complex which is thought to couple mRNA transcription, processing and nuclear export, and which specifically associates with spliced mRNA and not with unspliced pre-mRNA. TREX is recruited to spliced mRNAs by a transcription-independent mechanism, binds to mRNA upstream of the exon-junction complex (EJC) and is recruited in a splicing- and cap-dependent manner to a region near the 5' end of the mRNA where it functions in mRNA export to the cytoplasm via the TAP/NFX1 pathway. The TREX complex is essential for the export of Kaposi's sarcoma-associated herpesvirus (KSHV) intronless mRNAs and infectious virus production. THOC5 in conjunction with ALYREF/THOC4 functions in NXF1-NXT1 mediated nuclear export of HSP70 mRNA; both proteins enhance the RNA binding activity of NXF1 and are required for NXF1 localization to the nuclear rim. Involved in transcription elongation and genome stability. Involved in alternative polyadenylation site choi ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000397871
  • ENSP00000380969
  • ENSG00000100296
  • ENST00000397872
  • ENSP00000380970
  • ENST00000397873
  • ENSP00000380971
  • ENST00000490103
  • ENSP00000420306

Symbol
  • C22orf19
  • KIAA0983
  • Fmip
  • PK1.3
  • fSAP79
  • C22orf19
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0.93
histone modification site profile
0.91
transcription factor binding site profile
0.77
kinase perturbation
0.71
transcription factor
0.59


Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 27.45   (req: < 5)
Gene RIFs: 8   (req: <= 3)
Antibodies: 182   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 27.45   (req: >= 5)
Gene RIFs: 8   (req: > 3)
Antibodies: 182   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (7)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
self reported educational attainment
1
1
1
52.7
high density lipoprotein cholesterol measurement
1
1
1
46.9
apolipoprotein A 1 measurement
1
1
1
40.7
lifestyle measurement
1
1
1
30.2
heel bone mineral density
2
1
3
28.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
self reported educational attainment
1
52.7
high density lipoprotein cholesterol measurement
1
46.9
apolipoprotein A 1 measurement
1
40.7
lifestyle measurement
1
30.2
heel bone mineral density
3
28.8
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
THO complex 5
VGNC:5995
458742
Macaque
THO complex 5
714842
Mouse
MGI:1351333
107829
Rat
RGD:1304991
360972
Dog
THO complex 5
VGNC:47351
477534
Species
Name
OMA
EggNOG
Inparanoid
Chimp
THO complex 5
Macaque
THO complex 5
Mouse
Rat
Dog
THO complex 5
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q13769-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (9)
Gene expression (Transcription) (R-HSA-74160)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 8
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Gene expression (Transcription)
Reactome
Metabolism of RNA
Reactome
Processing of Capped Intron-Containing Pre-mRNA
Reactome
RNA Polymerase II Transcription
Reactome
RNA Polymerase II Transcription Termination
Name
Explore in Pharos
Explore in Source
Gene expression (Transcription)
Metabolism of RNA
Processing of Capped Intron-Containing Pre-mRNA
RNA Polymerase II Transcription
RNA Polymerase II Transcription Termination
Gene Ontology Terms (17)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Protein-Protein Interactions (158)
1 – 10 of 158
THOC1
Tbio
Novelty:  0.03702557
p_int:  0.999996454
p_ni:  0.000003546
Score:  0.999
Data Source:  BioPlex,STRINGDB
THOC3
Tbio
Novelty:  0.04716962
p_int:  0.999918025
p_ni:  0.000081975
Score:  0.999
Data Source:  BioPlex,STRINGDB
MRPL12
Tbio
Novelty:  0.10646542
p_int:  0.990464491
p_ni:  0.009535509
Score:  0.174
Data Source:  BioPlex,STRINGDB
TNFAIP6
Tbio
Novelty:  0.0046811
p_int:  0.91975
p_ni:  0.08025
Data Source:  BioPlex
SARNP
Tbio
Novelty:  0.00987312
p_int:  0.844772885
p_ni:  0.155227115
Score:  0.995
Data Source:  BioPlex,STRINGDB
NCBP1
Tbio
Novelty:  0.01228885
Score:  0.999
Data Source:  STRINGDB
THOC7
Tbio
Novelty:  0.16971494
Score:  0.999
Data Source:  STRINGDB
THOC2
Tbio
Novelty:  0.02886456
Score:  0.999
Data Source:  STRINGDB
THOC6
Tbio
Novelty:  0.0744541
Score:  0.999
Data Source:  STRINGDB
ALYREF
Tbio
Novelty:  0.00523802
Score:  0.998
Data Source:  STRINGDB
Publication Statistics
PubMed Score  27.45

PubMed score by year
PubTator Score  18.22

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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