Tbio Q13765 Nascent polypeptide-associated complex subunit alpha

Protein Summary

Description

Prevents inappropriate targeting of non-secretory polypeptides to the endoplasmic reticulum (ER). Binds to nascent polypeptide chains as they emerge from the ribosome and blocks their interaction with the signal recognition particle (SRP), which normally targets nascent secretory peptides to the ER. Also reduces the inherent affinity of ribosomes for protein translocation sites in the ER membrane (M sites). May act as a specific coactivator for JUN, binding to DNA and stabilizing the interaction of JUN homodimers with target gene promoters. This gene encodes a protein that associates with basic transcription factor 3 (BTF3) to form the nascent polypeptide-associated complex (NAC). This complex binds to nascent proteins that lack a signal peptide motif as they emerge from the ribosome, blocking interaction with the signal recognition particle (SRP) and preventing mistranslocation to the endoplasmic reticulum. This protein is an IgE autoantigen in atopic dermatitis patients. Alternative splicing results in multiple transcript variants, but the full length nature of some of these variants, including those encoding very large proteins, has not been determined. There are multiple pseudogenes of this gene on different chromosomes. [provided by RefSeq, Feb 2016]

Uniprot Accession IDs

• Q13765
• A8MTN7
• B2R4P8
• F8VU71
• Q3KQV4
• Q53A18
• Q53G46
• NAC-alpha

Gene Name

• NACA

Ensembl ID

• ENST00000356769
• ENSP00000349212
• ENSG00000196531
• ENST00000393891
• ENSP00000377469
• ENST00000546392
• ENSP00000446801
• ENST00000552540
• ENSP00000447821

Symbol

• HSD48
• NACA1
• skNAC
• NAC-alpha

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
co-expressed gene	1
interacting protein	1
disease perturbation	0.99
protein complex	0.95
kinase perturbation	0.88

Protein Classes

DTO Classes

Nascent Polypeptide-associated Complex Subunit Alpha-2 / Nascent Polypeptide-associated Complex Subunit Alpha, Muscle-specific Form / Putative Nascent Polypeptide-associated Complex Subunit Alpha-like Protein

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 26.86   (req: < 5)

Gene RIFs: 15   (req: <= 3)

Antibodies: 81   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 26.86   (req: >= 5)

Gene RIFs: 15   (req: > 3)

Antibodies: 81   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 13

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0