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Tbio
Q13765
Nascent polypeptide-associated complex subunit alpha

Protein Summary
Description
Prevents inappropriate targeting of non-secretory polypeptides to the endoplasmic reticulum (ER). Binds to nascent polypeptide chains as they emerge from the ribosome and blocks their interaction with the signal recognition particle (SRP), which normally targets nascent secretory peptides to the ER. Also reduces the inherent affinity of ribosomes for protein translocation sites in the ER membrane (M sites). May act as a specific coactivator for JUN, binding to DNA and stabilizing the interaction of JUN homodimers with target gene promoters. This gene encodes a protein that associates with basic transcription factor 3 (BTF3) to form the nascent polypeptide-associated complex (NAC). This complex binds to nascent proteins that lack a signal peptide motif as they emerge from the ribosome, blocking interaction with the signal recognition particle (SRP) and preventing mistranslocation to the endoplasmic reticulum. This protein is an IgE autoantigen in atopic dermatitis patients. Alternative ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000356769
  • ENSP00000349212
  • ENSG00000196531
  • ENST00000393891
  • ENSP00000377469
  • ENST00000546392
  • ENSP00000446801
  • ENST00000552540
  • ENSP00000447821

Symbol
  • HSD48
  • NACA1
  • skNAC
  • NAC-alpha
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
co-expressed gene
1
interacting protein
1
disease perturbation
0.99
protein complex
0.95
kinase perturbation
0.88


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 19.42   (req: < 5)
Gene RIFs: 12   (req: <= 3)
Antibodies: 81   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 19.42   (req: >= 5)
Gene RIFs: 12   (req: > 3)
Antibodies: 81   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 13
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
ARCHS4
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ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (195)
BTF3
Tbio
Novelty:  0.01198537
Score:  0.999
Data Source:  STRINGDB
BTF3L4
Tdark
Novelty:  0.61724061
Score:  0.996
Data Source:  STRINGDB
RPL4
Tbio
Novelty:  0.00475169
Score:  0.945
Data Source:  STRINGDB
RPL12
Tbio
Novelty:  0.01176619
Score:  0.94
Data Source:  STRINGDB
RPL7
Tbio
Novelty:  0.00552644
Score:  0.94
Data Source:  STRINGDB
RPL13A
Tbio
Novelty:  0.00503698
Score:  0.921
Data Source:  STRINGDB
RPL35
Tbio
Novelty:  0.03722634
Score:  0.918
Data Source:  STRINGDB
ILK
Tchem
Family:  Kinase
Novelty:  0.00147344
Score:  0.911
Data Source:  STRINGDB
RPL13
Tbio
Novelty:  0.0159486
Score:  0.906
Data Source:  STRINGDB
RPS8
Tbio
Novelty:  0.00976281
Score:  0.902
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (21)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean platelet volume
4
4
10
98.3
platelet count
3
3
4
2.8
96.1
appendicular lean mass
3
1
6
79.9
mean corpuscular hemoglobin concentration
1
1
2
78.9
reticulocyte count
4
3
8
77.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean platelet volume
10
98.3
platelet count
4
2.8
96.1
appendicular lean mass
6
79.9
mean corpuscular hemoglobin concentration
2
78.9
reticulocyte count
8
77.8
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs
No orthologs found
Publication Statistics
PubMed Score 19.42
PubMed score by year
PubTator Score 121.08
PubTator score by year
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Related Publications
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PMID
Year
Title