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Tbio
RUNX3
Runt-related transcription factor 3

Protein Summary
Description
Forms the heterodimeric complex core-binding factor (CBF) with CBFB. RUNX members modulate the transcription of their target genes through recognizing the core consensus binding sequence 5'-TGTGGT-3', or very rarely, 5'-TGCGGT-3', within their regulatory regions via their runt domain, while CBFB is a non-DNA-binding regulatory subunit that allosterically enhances the sequence-specific DNA-binding capacity of RUNX. The heterodimers bind to the core site of a number of enhancers and promoters, including murine leukemia virus, polyomavirus enhancer, T-cell receptor enhancers, LCK, IL3 and GM-CSF promoters (By similarity). May be involved in the control of cellular proliferation and/or differentiation. In association with ZFHX3, upregulates CDKN1A promoter activity following TGF-beta stimulation (PubMed:20599712). CBF complexes repress ZBTB7B transcription factor during cytotoxic (CD8+) T cell development. They bind to RUNX-binding sequence within the ZBTB7B locus acting as transcriptional ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000308873
  • ENSP00000308051
  • ENSG00000020633
  • ENST00000338888
  • ENSP00000343477
  • ENST00000399916
  • ENSP00000382800

Symbol
  • AML2
  • CBFA3
  • PEBP2A3
  • AML2
  • CBFA3
  • PEBP2aC
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.96
protein domain
0.92
biological process
0.86
hub protein
0.85
kinase perturbation
0.84


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 756.99   (req: < 5)
Gene RIFs: 300   (req: <= 3)
Antibodies: 627   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 756.99   (req: >= 5)
Gene RIFs: 300   (req: > 3)
Antibodies: 627   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 18
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (20)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
Eczema
2
2
0
1
92.9
2
2
0
1
92.9
5
4
0
1
91.4
lymphocyte count
2
2
2
79.3
eosinophil count
2
2
2
76
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
Eczema
0
1
92.9
0
1
92.9
0
1
91.4
lymphocyte count
2
79.3
eosinophil count
2
76
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
runt related transcription factor 3
VGNC:6989
456633
Macaque
runt related transcription factor 3
719447
Mouse
MGI:102672
12399
Rat
RGD:620082
156726
Dog
runt related transcription factor 3 [Source:HGNC Symbol;Acc:HGNC:10473]
Species
Name
OMA
EggNOG
Inparanoid
Chimp
runt related transcription factor 3
Macaque
runt related transcription factor 3
Mouse
Rat
Dog
runt related transcription factor 3 [Source:HGNC Symbol;Acc:HGNC:10473]
Protein Data Bank (1)
1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (72)
Binding of TCF/LEF:CTNNB1 to target gene promoters (R-HSA-4411364)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 18
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Binding of TCF/LEF:CTNNB1 to target gene promoters
Reactome
Formation of the beta-catenin:TCF transactivating complex
Reactome
Gene expression (Transcription)
Reactome
Generic Transcription Pathway
Reactome
RNA Polymerase II Transcription
Name
Explore in Pharos
Explore in Source
Binding of TCF/LEF:CTNNB1 to target gene promoters
Formation of the beta-catenin:TCF transactivating complex
Gene expression (Transcription)
Generic Transcription Pathway
RNA Polymerase II Transcription
Gene Ontology Terms (26)
Items per page:
10
1 – 4 of 4
GO Term
Evidence
Assigned by
Inferred from Sequence or structural Similarity (ISS)
BHF-UCL
Inferred from Sequence or structural Similarity (ISS)
BHF-UCL
Traceable Author Statement (TAS)
ProtInc
Non-traceable Author Statement (NAS)
UniProtKB
Protein-Protein Interactions (244)
1 – 10 of 244
CBFB
Tchem
Family: TF
Novelty: 0.04825679
p_int: 0.999996336
p_ni: 0.000003591
p_wrong: 7.3e-8
Score: 0.996
Data Source: BioPlex,Reactome,STRINGDB
RCBTB2
Tbio
Novelty: 0.04244536
p_int: 0.950063665
p_ni: 0.032400654
p_wrong: 0.017535681
Data Source: BioPlex
NOTCH1
Tchem
Novelty: 0.00012547
Score: 0.976
Data Source: STRINGDB
TP53
Tchem
Family: TF
Novelty: 0.00001907
Score: 0.973
Data Source: Reactome,STRINGDB
CCND1
Tchem
Novelty: 0.0001186
Score: 0.971
Data Source: Reactome,STRINGDB
MYC
Tbio
Family: TF
Novelty: 0.00005734
Score: 0.967
Data Source: STRINGDB
BCL2L11
Tbio
Novelty: 0.00055914
Score: 0.965
Data Source: STRINGDB
CDKN2A
Tbio
Novelty: 0.00014147
Score: 0.965
Data Source: STRINGDB
TBX21
Tbio
Family: TF
Novelty: 0.0009971
Score: 0.965
Data Source: STRINGDB
CDKN2A
Tbio
Family: Enzyme
Novelty: 0.00014147
Score: 0.965
Data Source: STRINGDB
Publication Statistics
PubMed Score  756.99

PubMed score by year
PubTator Score  479.47

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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