LAMB3
Laminin subunit beta-3
Protein Summary
Binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components. The product encoded by this gene is a laminin that belongs to a family of basement membrane proteins. This protein is a beta subunit laminin, which together with an alpha and a gamma subunit, forms laminin-5. Mutations in this gene cause epidermolysis bullosa junctional Herlitz type, and generalized atrophic benign epidermolysis bullosa, diseases that are characterized by blistering of the skin. Multiple alternatively spliced transcript variants that encode the same protein have been found for this gene. [provided by RefSeq, Jul 2008]
- ENST00000356082
- ENSP00000348384
- ENSG00000196878
- ENST00000367030
- ENSP00000355997
- ENST00000391911
- ENSP00000375778
- LAMNB1
- AI1A
- LAM5
- LAMNB1
- BM600-125KDA
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
gene perturbation | 0.98 | ||
transcription factor perturbation | 0.84 | ||
small molecule perturbation | 0.68 | ||
virus perturbation | 0.68 | ||
PubMedID | 0.65 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 175.16 (req: < 5)
Gene RIFs: 73 (req: <= 3)
Antibodies: 332 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 175.16 (req: >= 5)
Gene RIFs: 73 (req: > 3)
Antibodies: 332 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 8
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0