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Tchem
ACVR2B
Activin receptor type-2B

Protein Summary
Description
Transmembrane serine/threonine kinase activin type-2 receptor forming an activin receptor complex with activin type-1 serine/threonine kinase receptors (ACVR1, ACVR1B or ACVR1c). Transduces the activin signal from the cell surface to the cytoplasm and is thus regulating many physiological and pathological processes including neuronal differentiation and neuronal survival, hair follicle development and cycling, FSH production by the pituitary gland, wound healing, extracellular matrix production, immunosuppression and carcinogenesis. Activin is also thought to have a paracrine or autocrine role in follicular development in the ovary. Within the receptor complex, the type-2 receptors act as a primary activin receptors (binds activin-A/INHBA, activin-B/INHBB as well as inhibin-A/INHA-INHBA). The type-1 receptors like ACVR1B act as downstream transducers of activin signals. Activin binds to type-2 receptor at the plasma membrane and activates its serine-threonine kinase. The activated rece ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000352511
  • ENSP00000340361
  • ENSG00000114739

Symbol
  • HTX4
  • ACTRIIB
  • ActR-IIB
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
1
biological process
0.97
small molecule perturbation
0.76
transcription factor perturbation
0.74
protein domain
0.73


Related Tools
ProKinO
The ProKinO is a protein kinase-specific ontology, which provides a controlled vocabulary of terms, their hierarchy, and relationships unifying sequence, structure, function, mutation and pathway information on kinases.
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 163.21   (req: < 5)
Gene RIFs: 20   (req: <= 3)
Antibodies: 394   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 163.21   (req: >= 5)
Gene RIFs: 20   (req: > 3)
Antibodies: 394   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 45
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 3
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
glomerular filtration rate
1
1
1
55.3
comparative body size at age 10, self-reported
1
1
1
11.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
glomerular filtration rate
1
55.3
comparative body size at age 10, self-reported
1
11.8
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
activin A receptor type 2B
VGNC:11330
460271
Macaque
activin A receptor type 2B
696071
Mouse
MGI:87912
11481
Rat
RGD:2028
25366
Dog
activin A receptor type 2B
VGNC:37565
485590
Species
Name
OMA
EggNOG
Inparanoid
Chimp
activin A receptor type 2B
Macaque
activin A receptor type 2B
Mouse
Rat
Dog
activin A receptor type 2B
Protein Structure (5 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q13705-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 5 of 5
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (22)
Developmental Biology (R-HSA-1266738)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 7
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Developmental Biology
Reactome
Regulation of signaling by NODAL
Reactome
Signal Transduction
Reactome
Signaling by Activin
Reactome
Signaling by BMP
Name
Explore in Pharos
Explore in Source
Developmental Biology
Regulation of signaling by NODAL
Signal Transduction
Signaling by Activin
Signaling by BMP
Gene Ontology Terms (51)
Items per page:
10
1 – 10 of 10
GO Term
Evidence
Assigned by
Inferred from Physical Interaction (IPI)
HGNC
Inferred from Mutant Phenotype (IMP)
HGNC
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
Ensembl
Protein-Protein Interactions (167)
1 – 10 of 167
ACVR2A
Tchem
Family: Kinase
Novelty: 0.0063932
p_int: 0.999999975
p_ni: 2e-8
p_wrong: 6e-9
Score: 0.904
Data Source: BioPlex,Reactome,STRINGDB
DLK1
Tchem
Novelty: 0.00212394
p_int: 0.999995284
p_ni: 0.000004709
p_wrong: 6e-9
Score: 0.197
Data Source: BioPlex,STRINGDB
IQSEC2
Tbio
Novelty: 0.01878611
p_int: 0.999898948
p_ni: 0.000085721
p_wrong: 0.000015331
Data Source: BioPlex
PKN3
Tbio
Family: Kinase
Novelty: 0.0516816
p_int: 0.999801269
p_ni: 0.000198731
Data Source: BioPlex
C2CD2L
Tbio
Novelty: 0.2051681
p_int: 0.999696686
p_ni: 0.000303307
p_wrong: 7e-9
Data Source: BioPlex
TGFBR2
Tchem
Family: Kinase
Novelty: 0.00085381
p_int: 0.999678794
p_ni: 0.000314222
p_wrong: 0.000006985
Score: 0.189
Data Source: BioPlex,STRINGDB
FMN2
Tbio
Novelty: 0.02031944
p_int: 0.999388385
p_ni: 0.00061156
p_wrong: 5.5e-8
Data Source: BioPlex
LRRIQ1
Tdark
Novelty: 1.8251367
p_int: 0.999190859
p_ni: 0.000809098
p_wrong: 4.3e-8
Score: 0.197
Data Source: BioPlex,STRINGDB
PCDHGA5
Tdark
Novelty: 2.13631603
p_int: 0.998468172
p_ni: 0.001531714
p_wrong: 1.14e-7
Data Source: BioPlex
TMEM30A
Tbio
Novelty: 0.05115559
p_int: 0.997389248
p_ni: 0.002585068
p_wrong: 0.000025685
Data Source: BioPlex
Publication Statistics
PubMed Score  163.21

PubMed score by year
PubTator Score  68.87

PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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