Tclin CACNA1S Voltage-dependent L-type calcium channel subunit alpha-1S

Protein Summary

Description

Pore-forming, alpha-1S subunit of the voltage-gated calcium channel that gives rise to L-type calcium currents in skeletal muscle. Calcium channels containing the alpha-1S subunit play an important role in excitation-contraction coupling in skeletal muscle via their interaction with RYR1, which triggers Ca(2+) release from the sarcplasmic reticulum and ultimately results in muscle contraction. Long-lasting (L-type) calcium channels belong to the 'high-voltage activated' (HVA) group. This gene encodes one of the five subunits of the slowly inactivating L-type voltage-dependent calcium channel in skeletal muscle cells. Mutations in this gene have been associated with hypokalemic periodic paralysis, thyrotoxic periodic paralysis and malignant hyperthermia susceptibility. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• Q13698
• A4IF51
• B1ALM2
• Q12896
• Q13934

Gene Name

• CACNA1S

Ensembl ID

• ENST00000362061
• ENSP00000355192
• ENSG00000081248

Symbol

• CACH1
• CACN1
• CACNL1A3
• MHS5
• HOKPP
• TTPP1
• Cav1.1
• HOKPP1
• hypoPP
• CCHL1A3
• CACNL1A3

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
molecular function	0.9
protein domain	0.85
drug	0.72
cellular component	0.69
gene perturbation	0.65

Protein Classes

DTO Classes

Protein / Ion Channel / Calcium Channel Alpha-1 Subunit Family / Cacna1s Subfamily / Voltage-dependent L-type Calcium Channel Subunit Alpha-1s

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 235.4   (req: < 5)

Gene RIFs: 50   (req: <= 3)

Antibodies: 159   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 235.4   (req: >= 5)

Gene RIFs: 50   (req: > 3)

Antibodies: 159   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 40

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 5