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Tbio
AAMP
Angio-associated migratory cell protein

Protein Summary
Description
Plays a role in angiogenesis and cell migration. In smooth muscle cell migration, may act through the RhoA pathway. The gene is a member of the immunoglobulin superfamily. The encoded protein is associated with angiogenesis, with potential roles in endothelial tube formation and the migration of endothelial cells. It may also regulate smooth muscle cell migration via the RhoA pathway. The encoded protein can bind to heparin and may mediate heparin-sensitive cell adhesion. [provided by RefSeq, Oct 2014]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000248450
  • ENSP00000248450
  • ENSG00000127837
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
0.98
kinase perturbation
0.81
gene perturbation
0.76
transcription factor binding site profile
0.71
interacting protein
0.7


Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 58.32   (req: < 5)
Gene RIFs: 6   (req: <= 3)
Antibodies: 157   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 58.32   (req: >= 5)
Gene RIFs: 6   (req: > 3)
Antibodies: 157   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (28)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
red blood cell distribution width
4
4
4
96.9
mean platelet volume
3
3
5
94.2
reticulocyte count
6
4
6
92.1
monocyte count
2
2
2
90.5
reticulocyte measurement
3
2
3
89
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
red blood cell distribution width
4
96.9
mean platelet volume
5
94.2
reticulocyte count
6
92.1
monocyte count
2
90.5
reticulocyte measurement
3
89
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
angio associated migratory cell protein
VGNC:46
459940
Macaque
angio associated migratory cell protein
700763
Mouse
MGI:107809
227290
Rat
RGD:1306281
301512
Dog
angio associated migratory cell protein
VGNC:37412
478908
Species
Name
OMA
EggNOG
Inparanoid
Chimp
angio associated migratory cell protein
Macaque
angio associated migratory cell protein
Mouse
Rat
Dog
angio associated migratory cell protein
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q13685-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (19)
Items per page:
1 – 5 of 19
Data Source
Name
Explore in Pharos
Explore in Source
WikiPathways
Nucleotide-binding Oligomerization Domain (NOD) pathway
WikiPathways
Nucleotide-binding Oligomerization Domain (NOD) pathway
WikiPathways
Androgen receptor signaling pathway
WikiPathways
Interleukin-11 Signaling Pathway
WikiPathways
IL-4 Signaling Pathway
Name
Explore in Pharos
Explore in Source
Nucleotide-binding Oligomerization Domain (NOD) pathway
Nucleotide-binding Oligomerization Domain (NOD) pathway
Androgen receptor signaling pathway
Interleukin-11 Signaling Pathway
IL-4 Signaling Pathway
Gene Ontology Terms (12)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Protein-Protein Interactions (129)
1 – 10 of 129
AEN
Tbio
Family:  Enzyme
Novelty:  0.04318322
p_int:  0.999987832
p_ni:  2e-9
p_wrong:  0.000012166
Score:  0.574
Data Source:  BioPlex,STRINGDB
ASAH1
Tchem
Family:  Enzyme
Novelty:  0.00374228
p_int:  0.999340787
p_ni:  0.000638277
p_wrong:  0.000020936
Score:  0.193
Data Source:  BioPlex,STRINGDB
PTPRU
Tbio
Family:  Enzyme
Novelty:  0.0090218
p_int:  0.995518575
p_ni:  0.004481425
Score:  0.295
Data Source:  BioPlex,STRINGDB
WNK1
Tchem
Family:  Kinase
Novelty:  0.00270535
p_int:  0.983155993
p_ni:  0.016840615
p_wrong:  0.000003392
Score:  0.234
Data Source:  BioPlex,STRINGDB
RPL10
Tbio
Novelty:  0.01299391
p_int:  0.979175145
p_ni:  0.020824855
Score:  0.925
Data Source:  BioPlex,STRINGDB
INPP5K
Tbio
Family:  Enzyme
Novelty:  0.07282504
p_int:  0.956985641
p_ni:  0.043014359
Score:  0.234
Data Source:  BioPlex,STRINGDB
ACE2
Tchem
Family:  Enzyme
Novelty:  0.00028408
p_int:  0.821892143
p_ni:  1.5e-8
p_wrong:  0.178107842
Score:  0.519
Data Source:  BioPlex,STRINGDB
WDR12
Tbio
Novelty:  0.03409059
Score:  0.952
Data Source:  STRINGDB
RRS1
Tbio
Novelty:  0.01643671
Score:  0.925
Data Source:  STRINGDB
GRWD1
Tbio
Novelty:  0.08851737
Score:  0.923
Data Source:  STRINGDB
Publication Statistics
PubMed Score  58.32

PubMed score by year
PubTator Score  11.83

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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