Protein Summary
Integrin alpha-7/beta-1 is the primary laminin receptor on skeletal myoblasts and adult myofibers. During myogenic differentiation, it may induce changes in the shape and mobility of myoblasts, and facilitate their localization at laminin-rich sites of secondary fiber formation. It is involved in the maintenance of the myofibers cytoarchitecture as well as for their anchorage, viability and functional integrity. Isoform Alpha-7X2B and isoform Alpha-7X1B promote myoblast migration on laminin 1 and laminin 2/4, but isoform Alpha-7X1B is less active on laminin 1 (In vitro). Acts as Schwann cell receptor for laminin-2. Acts as a receptor of COMP and mediates its effect on vascular smooth muscle cells (VSMCs) maturation (By similarity). Required to promote contractile phenotype acquisition in differentiated airway smooth muscle (ASM) cells. The protein encoded by this gene belongs to the integrin alpha chain family. Integrins are heterodimeric integral membrane proteins composed of an alpha ...more
- ENST00000257879
- ENSP00000257879
- ENSG00000135424
- ENST00000452168
- ENSP00000393844
- ENST00000553804
- ENSP00000452120
- ENST00000555728
- ENSP00000452387
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
PubMedID | 0.89 | ||
cellular component | 0.79 | ||
gene perturbation | 0.74 | ||
protein domain | 0.73 | ||
cell type or tissue | 0.72 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 83.79 (req: < 5)
Gene RIFs: 22 (req: <= 3)
Antibodies: 254 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 83.79 (req: >= 5)
Gene RIFs: 22 (req: > 3)
Antibodies: 254 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 8
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
Related Tools
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (169)
TSPAN11
Novelty: 0.37247094
p_int: 0.999800575
p_ni: 0.000199425
Score: 0.282
Data Source: BioPlex,STRINGDB
ST8SIA4
Family: Enzyme
Novelty: 0.00338436
p_int: 0.999081442
p_ni: 0.000918558
Data Source: BioPlex
EDDM3B
Novelty: 0.12874735
p_int: 0.995787159
p_ni: 0.004212839
p_wrong: 2e-9
Data Source: BioPlex
PTCH1
Novelty: 0.00077635
p_int: 0.993660827
p_ni: 0.006339171
p_wrong: 2e-9
Data Source: BioPlex
ADAM18
Family: Enzyme
Novelty: 0.22622379
p_int: 0.977412278
p_ni: 0.022587554
p_wrong: 1.67e-7
Data Source: BioPlex
PCDHGA5
Novelty: 2.13631603
p_int: 0.970248928
p_ni: 0.029751055
p_wrong: 1.7e-8
Data Source: BioPlex
RLN1
Novelty: 0.03992636
p_int: 0.958284858
p_ni: 0.041713011
p_wrong: 0.000002131
Data Source: BioPlex
Nearest Tclin Targets (11)
Upstream (5)
Downstream (6)
1 – 5 of 5
Pathways (43)
Reactome (4)
KEGG (8)
PathwayCommons (6)
WikiPathways (25)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | ECM proteoglycans | ||||
Reactome | Extracellular matrix organization | ||||
Reactome | Integrin cell surface interactions | ||||
Reactome | Laminin interactions | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
ECM proteoglycans | ||||
Extracellular matrix organization | ||||
Integrin cell surface interactions | ||||
Laminin interactions | ||||
Viral Interactions (0)
Gene Ontology Terms (11)
Functions (1)
Components (3)
Processes (7)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Electronic Annotation (IEA) | UniProtKB-KW | |||
Disease Associations ()
GWAS Traits (10)
Items per page:
1 – 5 of 10
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
refractive error measurement | 3 | 3 | 3 | 13.8 | 96.4 | ||||
Myopia | 3 | 2 | 0 | 1.3 | 93 | ||||
age at onset | 1 | 1 | 0 | 13.8 | 83.1 | ||||
Abnormality of refraction | 1 | 1 | 1 | 53.3 | |||||
atrophic macular degeneration | 1 | 1 | 0 | 1.2 | 30.2 | ||||
Items per page:
1 – 5 of 10
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
refractive error measurement | 3 | 13.8 | 96.4 | ||||
Myopia | 0 | 1.3 | 93 | ||||
age at onset | 0 | 13.8 | 83.1 | ||||
Abnormality of refraction | 1 | 53.3 | |||||
atrophic macular degeneration | 0 | 1.2 | 30.2 | ||||
Find similar targets by:
IDG Resources
Orthologs (7)
1 – 5 of 7
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | integrin subunit alpha 7 | VGNC:5436 | 451967 | |||||
Mouse | MGI:102700 | 16404 | ||||||
Rat | RGD:71022 | 81008 | ||||||
Dog | integrin subunit alpha 7 | VGNC:42129 | 481097 | |||||
Horse | integrin subunit alpha 7 | VGNC:19168 | 100058756 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | integrin subunit alpha 7 | |||||
Mouse | ||||||
Rat | ||||||
Dog | integrin subunit alpha 7 | |||||
Horse | integrin subunit alpha 7 | |||||
Publication Statistics
PubMed Score 83.79
PubMed score by year
PubTator Score 33.06
PubTator score by year
Related Publications
Text Mined References (54)
GeneRif Annotations (22)
Items per page:
0 of 0
PMID | Year | Title |
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