Tbio ITGA7 Integrin alpha-7

Protein Summary

Description

Integrin alpha-7/beta-1 is the primary laminin receptor on skeletal myoblasts and adult myofibers. During myogenic differentiation, it may induce changes in the shape and mobility of myoblasts, and facilitate their localization at laminin-rich sites of secondary fiber formation. It is involved in the maintenance of the myofibers cytoarchitecture as well as for their anchorage, viability and functional integrity. Isoform Alpha-7X2B and isoform Alpha-7X1B promote myoblast migration on laminin 1 and laminin 2/4, but isoform Alpha-7X1B is less active on laminin 1 (In vitro). Acts as Schwann cell receptor for laminin-2. Acts as a receptor of COMP and mediates its effect on vascular smooth muscle cells (VSMCs) maturation (By similarity). Required to promote contractile phenotype acquisition in differentiated airway smooth muscle (ASM) cells. The protein encoded by this gene belongs to the integrin alpha chain family. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. They mediate a wide spectrum of cell-cell and cell-matrix interactions, and thus play a role in cell migration, morphologic development, differentiation, and metastasis. This protein functions as a receptor for the basement membrane protein laminin-1. It is mainly expressed in skeletal and cardiac muscles and may be involved in differentiation and migration processes during myogenesis. Defects in this gene are associated with congenital myopathy. Alternatively spliced transcript variants encoding different isoforms have been noted for this gene. [provided by RefSeq, Feb 2009]

Uniprot Accession IDs

• Q13683
• B4E3U0
• C9JMD3
• C9JMZ6
• O43197
• Q86W93
• Q9NY89
• Q9UET0
• Q9UEV2

Gene Name

• ITGA7

Ensembl ID

• ENST00000257879
• ENSP00000257879
• ENSG00000135424
• ENST00000452168
• ENSP00000393844
• ENST00000553804
• ENSP00000452120
• ENST00000555728
• ENSP00000452387

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
PubMedID	0.89
cellular component	0.79
gene perturbation	0.74
protein domain	0.73
cell type or tissue	0.72

Related Tools

GENEVA

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

Go To Tool

GlyGen

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

Go To Tool

ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

Go To Tool

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 80.93   (req: < 5)

Gene RIFs: 22   (req: <= 3)

Antibodies: 254   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 80.93   (req: >= 5)

Gene RIFs: 22   (req: > 3)

Antibodies: 254   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Orthologs (7)

1 – 5 of 7

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Chimp	integrin subunit alpha 7	VGNC:5436	451967
Mouse	integrin alpha 7	MGI:102700	16404
Rat	integrin subunit alpha 7	RGD:71022	81008
Dog	integrin subunit alpha 7	VGNC:42129	481097
Horse	integrin subunit alpha 7	VGNC:19168	100058756

Species	Name	OMA	EggNOG	Inparanoid
Chimp	integrin subunit alpha 7
Mouse	integrin alpha 7
Rat	integrin subunit alpha 7
Dog	integrin subunit alpha 7
Horse	integrin subunit alpha 7

Protein Structure (0 Structures, 1 AlphaFold Model)

Representation

  axes   backbone   ball+stick   cartoon   rocket   rope   spacefill

Color Scheme

  target   atomindex   bfactor   chainname   electrostatic   element   hydrophobicity   resname   sstruc

AF-Q13683-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (43)

Reactome (4)

KEGG (8)

PathwayCommons (6)

WikiPathways (25)

ECM proteoglycans (R-HSA-3000178)

Click on a row in the table to change the structure displayed.

Find Similar Targets

Items per page:

5

1 – 4 of 4

Data Source	Name	Explore in Pharos	Explore in Source
Reactome	ECM proteoglycans	56 targets	R-HSA-3000178
Reactome	Extracellular matrix organization	297 targets	R-HSA-1474244
Reactome	Integrin cell surface interactions	66 targets	R-HSA-216083
Reactome	Laminin interactions	23 targets	R-HSA-3000157

Name	Explore in Pharos	Explore in Source
ECM proteoglycans	56 targets	R-HSA-3000178
Extracellular matrix organization	297 targets	R-HSA-1474244
Integrin cell surface interactions	66 targets	R-HSA-216083
Laminin interactions	23 targets	R-HSA-3000157

Gene Ontology Terms (11)

Functions (1)

Components (3)

Processes (7)

Find Similar Targets

Items per page:

10

1 – 1 of 1

GO Term	Evidence	Assigned by
metal ion binding	Inferred from Electronic Annotation (IEA)	UniProtKB-KW

Protein-Protein Interactions (169)

Explore Interacting Targets

1 – 10 of 169

• See Interactions on String-DB

TSPAN11

Tdark

Novelty: 0.37247094

p_int: 0.999800575

p_ni: 0.000199425

Score: 0.282

Data Source: BioPlex,STRINGDB

SUSD4

Tbio

Novelty: 0.22201938

p_int: 0.999257032

p_ni: 0.000742968

Data Source: BioPlex

ST8SIA4

Tbio

Family: Enzyme

Novelty: 0.00338436

p_int: 0.999081442

p_ni: 0.000918558

Data Source: BioPlex

EDDM3B

Tdark

Novelty: 0.12874735

p_int: 0.995787159

p_ni: 0.004212839

p_wrong: 2e-9

Data Source: BioPlex

SLAMF1

Tbio

Novelty: 0.00112892

p_int: 0.994101359

p_ni: 0.005898641

Data Source: BioPlex

PTCH1

Tbio

Novelty: 0.00077635

p_int: 0.993660827

p_ni: 0.006339171

p_wrong: 2e-9

Data Source: BioPlex

TAZ

Tbio

Novelty: 0.00372301

p_int: 0.993226156

p_ni: 0.006773844

p_wrong: 1e-9

Data Source: BioPlex

ADAM18

Tdark

Family: Enzyme

Novelty: 0.22622379

p_int: 0.977412278

p_ni: 0.022587554

p_wrong: 1.67e-7

Data Source: BioPlex

PCDHGA5

Tdark

Novelty: 2.13631603

p_int: 0.970248928

p_ni: 0.029751055

p_wrong: 1.7e-8

Data Source: BioPlex

RLN1

Tbio

Novelty: 0.03992636

p_int: 0.958284858

p_ni: 0.041713011

p_wrong: 0.000002131

Data Source: BioPlex

Publication Statistics

PubMed Score  80.93

PubMed score by year

Reset Zoom

PubTator Score  33.06

PubTator score by year

Reset Zoom

Amino Acid Sequence

Residue Counts

Protein Sequence

Show Full Sequence

ProtVista Viewer

Find similar targets by:

UniProt Keyword Find Similar Targets

ADP-ribosylation
Alternative splicing
Calcium
Cell adhesion
Cell shape
Cleavage on pair of basic residues
Complete proteome
Congenital muscular dystrophy
Direct protein sequencing
Disulfide bond

MGI Phenotype Find Similar Targets

cardiovascular system phenotype
cellular phenotype
homeostasis/metabolism phenotype
mortality/aging
muscle phenotype
nervous system phenotype
skeleton phenotype