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Tbio
RIN1
Ras and Rab interactor 1

Protein Summary
Description
Ras effector protein, which may serve as an inhibitory modulator of neuronal plasticity in aversive memory formation. Can affect Ras signaling at different levels. First, by competing with RAF1 protein for binding to activated Ras. Second, by enhancing signaling from ABL1 and ABL2, which regulate cytoskeletal remodeling. Third, by activating RAB5A, possibly by functioning as a guanine nucleotide exchange factor (GEF) for RAB5A, by exchanging bound GDP for free GTP, and facilitating Ras-activated receptor endocytosis.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000311320
  • ENSP00000310406
  • ENSG00000174791
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor binding site profile
0.8
kinase
0.78
interacting protein
0.74
histone modification site profile
0.72
drug perturbation
0.71


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 53.42   (req: < 5)
Gene RIFs: 19   (req: <= 3)
Antibodies: 185   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 53.42   (req: >= 5)
Gene RIFs: 19   (req: > 3)
Antibodies: 185   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (59)
KRAS
Tclin
Family:  Enzyme
Novelty:  0.00013856
p_int:  0.999999965
p_ni:  2e-9
p_wrong:  3.3e-8
Score:  0.956
Data Source:  BioPlex,STRINGDB
ANKS1A
Tbio
Novelty:  0.01972212
p_int:  0.999999961
p_ni:  3.7e-8
p_wrong:  1e-9
Score:  0.32
Data Source:  BioPlex,STRINGDB
ABL2
Tchem
Family:  Kinase
Novelty:  0.00952983
p_int:  0.999982327
p_ni:  0.00001767
p_wrong:  3e-9
Score:  0.929
Data Source:  BioPlex,STRINGDB
NRAS
Tchem
Family:  Enzyme
Novelty:  0.00080922
p_int:  0.999946804
p_ni:  0.000053196
Score:  0.937
Data Source:  BioPlex,STRINGDB
HRAS
Tchem
Family:  Enzyme
Novelty:  0.00008069
p_int:  0.999920775
p_ni:  0.000079225
Score:  0.964
Data Source:  BioPlex,STRINGDB
RRAS
Tbio
Family:  Enzyme
Novelty:  0.00786502
p_int:  0.997861083
p_ni:  0.002138697
p_wrong:  2.2e-7
Score:  0.91
Data Source:  BioPlex,STRINGDB
YWHAZ
Tchem
Novelty:  0.00210582
p_int:  0.985319924
p_ni:  0.014680075
Score:  0.774
Data Source:  BioPlex,STRINGDB
ISCA1
Tbio
Novelty:  0.01288069
p_int:  0.984501895
p_ni:  0.01542762
p_wrong:  0.000070485
Data Source:  BioPlex
YWHAE
Tbio
Novelty:  0.00431876
p_int:  0.978150592
p_ni:  0.021849408
Score:  0.764
Data Source:  BioPlex,STRINGDB
RRAS2
Tbio
Family:  Enzyme
Novelty:  0.01870067
p_int:  0.97122315
p_ni:  0.02877685
Score:  0.91
Data Source:  BioPlex,STRINGDB
Pathways (10)
Membrane Trafficking (R-HSA-199991)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Membrane Trafficking
Reactome
RAB GEFs exchange GTP for GDP on RABs
Reactome
Rab regulation of trafficking
Reactome
Vesicle-mediated transport
Name
Explore in Pharos
Explore in Source
Membrane Trafficking
RAB GEFs exchange GTP for GDP on RABs
Rab regulation of trafficking
Vesicle-mediated transport
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (21)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
urate measurement
2
2
3
78.7
BMI-adjusted waist circumference
1
3
3
73.6
insomnia measurement
1
2
0
1
67.5
self reported educational attainment
3
2
3
67.4
BMI-adjusted hip circumference
2
1
2
56.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
urate measurement
3
78.7
BMI-adjusted waist circumference
3
73.6
insomnia measurement
0
1
67.5
self reported educational attainment
3
67.4
BMI-adjusted hip circumference
2
56.4
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
Ras and Rab interactor 1
VGNC:1020
466675
Macaque
Ras and Rab interactor 1
714321
Mouse
MGI:2385695
225870
Rat
RGD:11459991
108348044
Dog
Ras and Rab interactor 1
VGNC:45586
611928
Species
Name
OMA
EggNOG
Inparanoid
Chimp
Ras and Rab interactor 1
Macaque
Ras and Rab interactor 1
Mouse
Rat
Dog
Ras and Rab interactor 1
Publication Statistics
PubMed Score 53.42
PubMed score by year
PubTator Score 36.40
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title