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Tbio
IL10RA
Interleukin-10 receptor subunit alpha

Protein Summary
Description
Receptor for IL10; binds IL10 with a high affinity. The protein encoded by this gene is a receptor for interleukin 10. This protein is structurally related to interferon receptors. It has been shown to mediate the immunosuppressive signal of interleukin 10, and thus inhibits the synthesis of proinflammatory cytokines. This receptor is reported to promote survival of progenitor myeloid cells through the insulin receptor substrate-2/PI 3-kinase/AKT pathway. Activation of this receptor leads to tyrosine phosphorylation of JAK1 and TYK2 kinases. Two transcript variants, one protein-coding and the other not protein-coding, have been found for this gene. [provided by RefSeq, Jan 2009]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000227752
  • ENSP00000227752
  • ENSG00000110324

Symbol
  • IL10R
  • CD210
  • IL10R
  • CD210a
  • CDW210A
  • HIL-10R
  • IL-10R1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
gene perturbation
0.93
PubMedID
0.81
disease perturbation
0.74
virus perturbation
0.72
tissue sample
0.67


Related Tools
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 168.78   (req: < 5)
Gene RIFs: 69   (req: <= 3)
Antibodies: 781   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 168.78   (req: >= 5)
Gene RIFs: 69   (req: > 3)
Antibodies: 781   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
interleukin 10 receptor subunit alpha
704383
Mouse
MGI:96538
16154
Rat
RGD:620138
117539
Dog
interleukin 10 receptor subunit alpha
VGNC:41929
610823
Horse
interleukin 10 receptor subunit alpha
VGNC:18992
100071172
Species
Name
OMA
EggNOG
Inparanoid
Macaque
interleukin 10 receptor subunit alpha
Mouse
Rat
Dog
interleukin 10 receptor subunit alpha
Horse
interleukin 10 receptor subunit alpha
Protein Structure (6 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q13651-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 5 of 6
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (18)
Cytokine Signaling in Immune system (R-HSA-1280215)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cytokine Signaling in Immune system
Reactome
Immune System
Reactome
Interleukin-10 signaling
Reactome
Signaling by Interleukins
Name
Explore in Pharos
Explore in Source
Cytokine Signaling in Immune system
Immune System
Interleukin-10 signaling
Signaling by Interleukins
Protein-Protein Interactions (260)
1 – 10 of 260
IL10
Tbio
Novelty:  0.00004352
Score:  0.998
Data Source:  Reactome,STRINGDB
IL10RB
Tbio
Novelty:  0.00880915
Score:  0.995
Data Source:  Reactome,STRINGDB
JAK1
Tclin
Family:  Kinase
Novelty:  0.00093625
Score:  0.994
Data Source:  Reactome,STRINGDB
STAT3
Tchem
Family:  TF
Novelty:  0.00011808
Score:  0.975
Data Source:  Reactome,STRINGDB
IL22RA1
Tbio
Novelty:  0.01107638
Score:  0.962
Data Source:  STRINGDB
STAT1
Tchem
Family:  TF
Novelty:  0.0003383
Score:  0.96
Data Source:  STRINGDB
TYK2
Tclin
Family:  Kinase
Novelty:  0.00237955
Score:  0.959
Data Source:  Reactome,STRINGDB
STAT5A
Tchem
Family:  TF
Novelty:  0.00074026
Score:  0.951
Data Source:  STRINGDB
STAT5B
Tchem
Family:  TF
Novelty:  0.00074178
Score:  0.946
Data Source:  STRINGDB
IL22
Tbio
Novelty:  0.0023754
Score:  0.939
Data Source:  STRINGDB
Publication Statistics
PubMed Score  168.78

PubMed score by year
PubTator Score  145.21

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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