IL10RA
Interleukin-10 receptor subunit alpha
Protein Summary
Receptor for IL10; binds IL10 with a high affinity. The protein encoded by this gene is a receptor for interleukin 10. This protein is structurally related to interferon receptors. It has been shown to mediate the immunosuppressive signal of interleukin 10, and thus inhibits the synthesis of proinflammatory cytokines. This receptor is reported to promote survival of progenitor myeloid cells through the insulin receptor substrate-2/PI 3-kinase/AKT pathway. Activation of this receptor leads to tyrosine phosphorylation of JAK1 and TYK2 kinases. Two transcript variants, one protein-coding and the other not protein-coding, have been found for this gene. [provided by RefSeq, Jan 2009]
- ENST00000227752
- ENSP00000227752
- ENSG00000110324
- IL10R
- CD210
- IL10R
- CD210a
- CDW210A
- HIL-10R
- IL-10R1
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
gene perturbation | 0.93 | ||
PubMedID | 0.81 | ||
disease perturbation | 0.74 | ||
virus perturbation | 0.72 | ||
tissue sample | 0.67 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 193.84 (req: < 5)
Gene RIFs: 81 (req: <= 3)
Antibodies: 781 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 193.84 (req: >= 5)
Gene RIFs: 81 (req: > 3)
Antibodies: 781 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 6
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0