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Tbio
TPBG
Trophoblast glycoprotein

Protein Summary
Description
May function as an inhibitor of Wnt/beta-catenin signaling by indirectly interacting with LRP6 and blocking Wnt3a-dependent LRP6 internalization. This gene encodes a leucine-rich transmembrane glycoprotein that may be involved in cell adhesion. The encoded protein is an oncofetal antigen that is specific to trophoblast cells. In adults this protein is highly expressed in many tumor cells and is associated with poor clinical outcome in numerous cancers. Alternate splicing in the 5' UTR results in multiple transcript variants that encode the same protein. [provided by RefSeq, Oct 2009]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000369750
  • ENSP00000358765
  • ENSG00000146242
  • ENST00000535040
  • ENSP00000441219
  • ENST00000543496
  • ENSP00000440049
  • ENST00000634817
  • ENSP00000489447
  • ENSG00000283085
  • ENST00000634826
  • ENSP00000489140
  • ENST00000635036
  • ENSP00000489143

Symbol
  • 5T4
  • 5T4
  • M6P1
  • 5T4AG
  • WAIF1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
PubMedID
0.94
kinase perturbation
0.93
transcription factor perturbation
0.8
gene perturbation
0.72
tissue sample
0.66


Related Tools
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 143.94   (req: < 5)
Gene RIFs: 14   (req: <= 3)
Antibodies: 292   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 143.94   (req: >= 5)
Gene RIFs: 14   (req: > 3)
Antibodies: 292   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
trophoblast glycoprotein
VGNC:12724
100611486
Macaque
trophoblast glycoprotein
693944
Mouse
MGI:1341264
21983
Rat
RGD:621453
83684
Dog
trophoblast glycoprotein
VGNC:47731
102156010
Species
Name
OMA
EggNOG
Inparanoid
Chimp
trophoblast glycoprotein
Macaque
trophoblast glycoprotein
Mouse
Rat
Dog
trophoblast glycoprotein
Protein Structure (2 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q13641-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 2 of 2
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Gene Ontology Terms (5)
Items per page:
10
1 – 3 of 3
GO Term
Evidence
Assigned by
Inferred from High Throughput Direct Assay (HDA)
UniProtKB
Traceable Author Statement (TAS)
ProtInc
Inferred from Electronic Annotation (IEA)
Ensembl
Protein-Protein Interactions (37)
1 – 10 of 37
FAM241A
Tdark
Novelty:  1.04041354
p_int:  0.999999865
p_ni:  1.5e-8
p_wrong:  1.2e-7
Data Source:  BioPlex
PODXL2
Tbio
Novelty:  0.09100487
p_int:  0.999322205
p_ni:  6.4e-8
p_wrong:  0.000677731
Data Source:  BioPlex
SMU1
Tbio
Novelty:  0.02232467
Score:  0.836
Data Source:  STRINGDB
USP39
Tbio
Novelty:  0.03914006
Score:  0.819
Data Source:  STRINGDB
SRSF11
Tbio
Novelty:  0.17035604
Score:  0.777
Data Source:  STRINGDB
TRIM33
Tchem
Family:  Epigenetic
Novelty:  0.00415877
Score:  0.753
Data Source:  STRINGDB
ADGRL1
Tbio
Family:  GPCR
Novelty:  0.00957739
Score:  0.685
Data Source:  STRINGDB
ADGRL2
Tbio
Family:  GPCR
Novelty:  0.00985539
Score:  0.685
Data Source:  STRINGDB
ADGRL3
Tbio
Family:  GPCR
Novelty:  0.00268343
Score:  0.685
Data Source:  STRINGDB
OPLAH
Tbio
Family:  Enzyme
Novelty:  0.03527462
Score:  0.599
Data Source:  STRINGDB
Publication Statistics
PubMed Score  143.94

PubMed score by year
PubTator Score  50.12

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer