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Tclin
HTR4
5-hydroxytryptamine receptor 4

Protein Summary
Description
This is one of the several different receptors for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. The activity of this receptor is mediated by G proteins that stimulate adenylate cyclase. This gene is a member of the family of serotonin receptors, which are G protein coupled receptors that stimulate cAMP production in response to serotonin (5-hydroxytryptamine). The gene product is a glycosylated transmembrane protein that functions in both the peripheral and central nervous system to modulate the release of various neurotransmitters. Multiple transcript variants encoding proteins with distinct C-terminal sequences have been described. [provided by RefSeq, May 2010]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000360693
  • ENSP00000353915
  • ENSG00000164270
  • ENST00000362016
  • ENSP00000355037
  • ENST00000377888
  • ENSP00000367120
  • ENST00000517929
  • ENSP00000435904
  • ENST00000520514
  • ENSP00000427913
  • ENST00000521530
  • ENSP00000428320
  • ENST00000521735
  • ENSP00000430979
  • ENST00000522588
  • ENSP00000430874
  • ENST00000631296
  • ENSP00000485747

Symbol
  • 5-HT4
  • 5-HT4R
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
co-expressed gene
0.98
ligand (chemical)
0.95
cell type or tissue
0.76
microRNA
0.7
biological term
0.65


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 113.43   (req: < 5)
Gene RIFs: 58   (req: <= 3)
Antibodies: 391   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 113.43   (req: >= 5)
Gene RIFs: 58   (req: > 3)
Antibodies: 391   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 364
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 7
GWAS Traits (31)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
forced expiratory volume
4
3
3
1.2
94.9
2
2
0
1.2
92.9
neutrophil count
3
2
3
84.3
lifestyle measurement
1
1
1
83
myeloid white cell count
2
2
2
78.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
forced expiratory volume
3
1.2
94.9
0
1.2
92.9
neutrophil count
3
84.3
lifestyle measurement
1
83
myeloid white cell count
2
78.6
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
5-hydroxytryptamine receptor 4
VGNC:13511
462175
Macaque
5-hydroxytryptamine receptor 4
710046
Mouse
MGI:109246
15562
Rat
RGD:2850
25324
Dog
5-hydroxytryptamine receptor 4
VGNC:41831
489198
Species
Name
OMA
EggNOG
Inparanoid
Chimp
5-hydroxytryptamine receptor 4
Macaque
5-hydroxytryptamine receptor 4
Mouse
Rat
Dog
5-hydroxytryptamine receptor 4
Protein Structure (1 Structure, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q13639-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (118)
Amine ligand-binding receptors (R-HSA-375280)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 8
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Amine ligand-binding receptors
Reactome
Class A/1 (Rhodopsin-like receptors)
Reactome
G alpha (s) signalling events
Reactome
GPCR downstream signalling
Reactome
GPCR ligand binding
Name
Explore in Pharos
Explore in Source
Amine ligand-binding receptors
Class A/1 (Rhodopsin-like receptors)
G alpha (s) signalling events
GPCR downstream signalling
GPCR ligand binding
Protein-Protein Interactions (143)
1 – 10 of 143
GIPR
Tchem
Family: GPCR
Novelty: 0.00961809
Score: 0.944
Data Source: STRINGDB
ADRB2
Tclin
Family: GPCR
Novelty: 0.00041821
Score: 0.938
Data Source: STRINGDB
GIP
Tchem
Novelty: 0.0007219
Score: 0.935
Data Source: STRINGDB
GNAS
Tbio
Novelty: 0.00284739
Score: 0.929
Data Source: STRINGDB
GNAS
Tbio
Novelty: 0.00284739
Score: 0.929
Data Source: STRINGDB
GNAS
Tbio
Novelty: 0.00284739
Score: 0.929
Data Source: STRINGDB
GNAS
Tbio
Novelty: 0.00284739
Score: 0.929
Data Source: STRINGDB
HTR6
Tchem
Family: GPCR
Novelty: 0.01492331
Score: 0.923
Data Source: STRINGDB
POMC
Tbio
Novelty: 0.00002436
Score: 0.922
Data Source: STRINGDB
GCGR
Tclin
Family: GPCR
Novelty: 0.00392059
Score: 0.921
Data Source: STRINGDB
Publication Statistics
PubMed Score  113.43

PubMed score by year
PubTator Score  90.73

PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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