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Tclin
HTR4
5-hydroxytryptamine receptor 4

Protein Summary
Description
This is one of the several different receptors for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. The activity of this receptor is mediated by G proteins that stimulate adenylate cyclase. This gene is a member of the family of serotonin receptors, which are G protein coupled receptors that stimulate cAMP production in response to serotonin (5-hydroxytryptamine). The gene product is a glycosylated transmembrane protein that functions in both the peripheral and central nervous system to modulate the release of various neurotransmitters. Multiple transcript variants encoding proteins with distinct C-terminal sequences have been described. [provided by RefSeq, May 2010]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000360693
  • ENSP00000353915
  • ENSG00000164270
  • ENST00000362016
  • ENSP00000355037
  • ENST00000377888
  • ENSP00000367120
  • ENST00000517929
  • ENSP00000435904
  • ENST00000520514
  • ENSP00000427913
  • ENST00000521530
  • ENSP00000428320
  • ENST00000521735
  • ENSP00000430979
  • ENST00000522588
  • ENSP00000430874
  • ENST00000631296
  • ENSP00000485747

Symbol
  • 5-HT4
  • 5-HT4R
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
co-expressed gene
0.98
ligand (chemical)
0.95
cell type or tissue
0.76
microRNA
0.7
biological term
0.65


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 144.79   (req: < 5)
Gene RIFs: 63   (req: <= 3)
Antibodies: 391   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 144.79   (req: >= 5)
Gene RIFs: 63   (req: > 3)
Antibodies: 391   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 441
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 7