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Tbio
RAB32
Ras-related protein Rab-32

Protein Summary
Description
Acts as an A-kinase anchoring protein by binding to the type II regulatory subunit of protein kinase A and anchoring it to the mitochondrion. Also involved in synchronization of mitochondrial fission (PubMed:12186851). Plays a role in the maturation of phagosomes that engulf pathogens, such as S.aureus and M.tuberculosis (PubMed:21255211). Plays an important role in the control of melanin production and melanosome biogenesis (PubMed:23084991). In concert with RAB38, regulates the proper trafficking of melanogenic enzymes TYR, TYRP1 and DCT/TYRP2 to melanosomes in melanocytes (By similarity). The protein encoded by this gene anchors the type II regulatory subunit of protein kinase A to the mitochondrion and aids in mitochondrial fission. The encoded protein also appears to be involved in autophagy and melanosome secretion. Variations in this gene may be linked to leprosy. [provided by RefSeq, Dec 2015]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000367495
  • ENSP00000356465
  • ENSG00000118508
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.98
kinase perturbation
0.81
PubMedID
0.76
virus perturbation
0.76
gene perturbation
0.68


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 47.8   (req: < 5)
Gene RIFs: 12   (req: <= 3)
Antibodies: 163   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 47.8   (req: >= 5)
Gene RIFs: 12   (req: > 3)
Antibodies: 163   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 15
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
1
1
0
1.3
30.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
1.3
30.3
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
RAB32, member RAS oncogene family
VGNC:9955
748474
Mouse
MGI:1915094
67844
Rat
RGD:1559997
365042
Dog
RAB32, member RAS oncogene family
VGNC:53757
100856634
Horse
RAB32, member RAS oncogene family [Source:HGNC Symbol;Acc:HGNC:9772]
Species
Name
OMA
EggNOG
Inparanoid
Chimp
RAB32, member RAS oncogene family
Mouse
Rat
Dog
RAB32, member RAS oncogene family
Horse
RAB32, member RAS oncogene family [Source:HGNC Symbol;Acc:HGNC:9772]
Protein Data Bank (4)
1 – 4 of 4
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (7)
Membrane Trafficking (R-HSA-199991)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 7
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Membrane Trafficking
Reactome
Metabolism of proteins
Reactome
Post-translational protein modification
Reactome
RAB GEFs exchange GTP for GDP on RABs
Reactome
RAB geranylgeranylation
Name
Explore in Pharos
Explore in Source
Membrane Trafficking
Metabolism of proteins
Post-translational protein modification
RAB GEFs exchange GTP for GDP on RABs
RAB geranylgeranylation
Gene Ontology Terms (27)
Items per page:
10
1 – 6 of 6
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
ParkinsonsUK-UCL
Inferred from Physical Interaction (IPI)
ParkinsonsUK-UCL
Inferred from Physical Interaction (IPI)
ParkinsonsUK-UCL
Inferred from Physical Interaction (IPI)
ParkinsonsUK-UCL
Non-traceable Author Statement (NAS)
ParkinsonsUK-UCL
Protein-Protein Interactions (133)
1 – 10 of 133
RAB38
Tbio
Family: Enzyme
Novelty: 0.02651645
p_int: 0.999999458
p_wrong: 5.42e-7
Score: 0.94
Data Source: BioPlex,STRINGDB
GDI1
Tbio
Novelty: 0.01710945
p_int: 0.999983172
p_ni: 0.000016828
Score: 0.918
Data Source: BioPlex,Reactome,STRINGDB
CHML
Tbio
Family: Enzyme
Novelty: 0.00509709
p_int: 0.999772172
p_ni: 0.000227813
p_wrong: 1.5e-8
Score: 0.941
Data Source: BioPlex,Reactome,STRINGDB
CHM
Tbio
Family: Enzyme
Novelty: 0.00226278
p_int: 0.996146277
p_ni: 0.003853718
p_wrong: 5e-9
Score: 0.947
Data Source: BioPlex,Reactome,STRINGDB
SLC39A12
Tbio
Family: Transporter
Novelty: 0.09127395
p_int: 0.959620529
p_ni: 0.036765844
p_wrong: 0.003613627
Data Source: BioPlex
GRPR
Tchem
Family: GPCR
Novelty: 0.00282511
p_int: 0.947765555
p_ni: 0.049546605
p_wrong: 0.00268784
Data Source: BioPlex
SLC22A6
Tclin
Family: Transporter
Novelty: 0.00389149
p_int: 0.945211408
p_ni: 0.053477724
p_wrong: 0.001310868
Data Source: BioPlex
LPAR6
Tchem
Family: GPCR
Novelty: 0.01801122
p_int: 0.943676917
p_ni: 0.054385453
p_wrong: 0.00193763
Data Source: BioPlex
CLTCL1
Tbio
Novelty: 0.05667807
p_int: 0.903125778
p_ni: 0.096874222
Score: 0.251
Data Source: BioPlex,STRINGDB
FCGR3A
Tbio
Novelty: 0.0004214
p_int: 0.872222528
p_ni: 0.127517837
p_wrong: 0.000259636
Score: 0.193
Data Source: BioPlex,STRINGDB
Publication Statistics
PubMed Score  47.80

PubMed score by year
PubTator Score  17.74

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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