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Tbio
RAB31
Ras-related protein Rab-31

Protein Summary
Description
The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. Required for the integrity and for normal function of the Golgi apparatus and the trans-Golgi network. Plays a role in insulin-stimulated translocation of GLUT4 to the cell membrane. Plays a role in M6PR transport from the trans-Golgi network to endosomes. Plays a role in the internalization of EGFR from the cell membrane into endosomes. Plays a role in the maturation of phagosomes that engulf pathogens, such as S.aureus and M.tuberculosis. Small GTP-binding proteins of the RAB family, such as RAB31, play essential roles in vesicle and granule targeting (Bao et al., 2002 [PubMed 11784320]).[supplied by OMIM, Jul 2 ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000578921
  • ENSP00000461945
  • ENSG00000168461

Symbol
  • RAB22B
  • Rab22B
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
1
kinase perturbation
0.99
transcription factor perturbation
0.99
PubMedID
0.92
molecular function
0.91


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 19.93   (req: < 5)
Gene RIFs: 11   (req: <= 3)
Antibodies: 167   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 19.93   (req: >= 5)
Gene RIFs: 11   (req: > 3)
Antibodies: 167   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 11
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Data Bank (1)
1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (11)
Immune System (R-HSA-168256)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 10
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Immune System
Reactome
Innate Immune System
Reactome
Membrane Trafficking
Reactome
Metabolism of proteins
Reactome
Neutrophil degranulation
Name
Explore in Pharos
Explore in Source
Immune System
Innate Immune System
Membrane Trafficking
Metabolism of proteins
Neutrophil degranulation
Gene Ontology Terms (19)
Items per page:
10
1 – 3 of 3
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Protein-Protein Interactions (116)
1 – 10 of 116
CHML
Tbio
Family: Enzyme
Novelty: 0.0116075
p_int: 0.999998638
p_ni: 0.000001362
Score: 0.967
Data Source: BioPlex,Reactome,STRINGDB
CHM
Tbio
Family: Enzyme
Novelty: 0.00301194
p_int: 0.9999986
p_ni: 0.0000014
Score: 0.966
Data Source: BioPlex,Reactome,STRINGDB
GDI1
Tbio
Novelty: 0.02210681
p_int: 0.999998547
p_ni: 0.000001453
Score: 0.98
Data Source: BioPlex,Reactome,STRINGDB
TRIM4
Tdark
Family: Enzyme
Novelty: 0.18378269
p_int: 0.999995738
p_ni: 0.000004262
Score: 0.228
Data Source: BioPlex,STRINGDB
RAB22A
Tbio
Family: Enzyme
Novelty: 0.03160034
p_int: 0.999995629
p_wrong: 0.00000437
Score: 0.983
Data Source: BioPlex,STRINGDB
RABGGTA
Tbio
Family: Enzyme
Novelty: 0.18518519
p_int: 0.999806698
p_ni: 0.000193302
Score: 0.981
Data Source: BioPlex,STRINGDB
RABGGTB
Tbio
Family: Enzyme
Novelty: 0.13346044
p_int: 0.992064394
p_ni: 0.007935606
Score: 0.914
Data Source: BioPlex,STRINGDB
GDI2
Tbio
Novelty: 0.03351296
p_int: 0.958567634
p_ni: 0.041432366
Score: 0.972
Data Source: BioPlex,Reactome,STRINGDB
GAPVD1
Tbio
Family: Enzyme
Novelty: 0.17216643
Score: 0.979
Data Source: Reactome,STRINGDB
RAB8A
Tbio
Family: Enzyme
Novelty: 0.00226947
Score: 0.944
Data Source: STRINGDB
Publication Statistics
PubMed Score  19.93

PubMed score by year
PubTator Score  14.57

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer