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Tbio
RAB31
Ras-related protein Rab-31

Protein Summary
Description
The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. Required for the integrity and for normal function of the Golgi apparatus and the trans-Golgi network. Plays a role in insulin-stimulated translocation of GLUT4 to the cell membrane. Plays a role in M6PR transport from the trans-Golgi network to endosomes. Plays a role in the internalization of EGFR from the cell membrane into endosomes. Plays a role in the maturation of phagosomes that engulf pathogens, such as S.aureus and M.tuberculosis. Small GTP-binding proteins of the RAB family, such as RAB31, play essential roles in vesicle and granule targeting (Bao et al., 2002 [PubMed 11784320]).[supplied by OMIM, Jul 2 ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000578921
  • ENSP00000461945
  • ENSG00000168461

Symbol
  • RAB22B
  • Rab22B
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
1
kinase perturbation
0.99
transcription factor perturbation
0.99
PubMedID
0.92
molecular function
0.91


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 31.87   (req: < 5)
Gene RIFs: 11   (req: <= 3)
Antibodies: 167   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 31.87   (req: >= 5)
Gene RIFs: 11   (req: > 3)
Antibodies: 167   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 11
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (116)
CHML
Tbio
Family:  Enzyme
Novelty:  0.00509709
p_int:  0.999998638
p_ni:  0.000001362
Score:  0.967
Data Source:  BioPlex,Reactome,STRINGDB
CHM
Tbio
Family:  Enzyme
Novelty:  0.00226278
p_int:  0.9999986
p_ni:  0.0000014
Score:  0.966
Data Source:  BioPlex,Reactome,STRINGDB
GDI1
Tbio
Novelty:  0.01710945
p_int:  0.999998547
p_ni:  0.000001453
Score:  0.98
Data Source:  BioPlex,Reactome,STRINGDB
TRIM4
Tbio
Family:  Enzyme
Novelty:  0.11398363
p_int:  0.999995738
p_ni:  0.000004262
Score:  0.228
Data Source:  BioPlex,STRINGDB
RAB22A
Tbio
Family:  Enzyme
Novelty:  0.02344687
p_int:  0.999995629
p_wrong:  0.00000437
Score:  0.983
Data Source:  BioPlex,STRINGDB
RABGGTA
Tdark
Family:  Enzyme
Novelty:  0.19962321
p_int:  0.999806698
p_ni:  0.000193302
Score:  0.981
Data Source:  BioPlex,STRINGDB
RABGGTB
Tbio
Family:  Enzyme
Novelty:  0.06786314
p_int:  0.992064394
p_ni:  0.007935606
Score:  0.914
Data Source:  BioPlex,STRINGDB
GDI2
Tbio
Novelty:  0.02861013
p_int:  0.958567634
p_ni:  0.041432366
Score:  0.972
Data Source:  BioPlex,Reactome,STRINGDB
GAPVD1
Tbio
Family:  Enzyme
Novelty:  0.13142098
Score:  0.979
Data Source:  Reactome,STRINGDB
RAB8A
Tbio
Family:  Enzyme
Novelty:  0.00486694
Score:  0.944
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (11)
Immune System (R-HSA-168256)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 10
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Immune System
Reactome
Innate Immune System
Reactome
Membrane Trafficking
Reactome
Metabolism of proteins
Reactome
Neutrophil degranulation
Name
Explore in Pharos
Explore in Source
Immune System
Innate Immune System
Membrane Trafficking
Metabolism of proteins
Neutrophil degranulation
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (19)
Find Similar Targets
Items per page:
10
1 – 3 of 3
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Disease Associations ()
No disease associations found
GWAS Traits (7)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean platelet volume
3
2
3
95.1
mathematical ability
2
2
2
66.3
platelet count
1
1
1
65.3
basophil count
2
1
2
49.5
Dupuytren Contracture
1
1
0
1.2
44.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean platelet volume
3
95.1
mathematical ability
2
66.3
platelet count
1
65.3
basophil count
2
49.5
Dupuytren Contracture
0
1.2
44.2
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (8)
1 – 5 of 8
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Mouse
MGI:1914603
106572
Rat
RGD:628598
246324
Dog
RAB31, member RAS oncogene family
VGNC:45274
608485
Horse
RAB31, member RAS oncogene family
VGNC:22107
100055265
Cow
RAB31, member RAS oncogene family
VGNC:33640
616979
Species
Name
OMA
EggNOG
Inparanoid
Mouse
Rat
Dog
RAB31, member RAS oncogene family
Horse
RAB31, member RAS oncogene family
Cow
RAB31, member RAS oncogene family
Publication Statistics
PubMed Score 31.87
PubMed score by year
PubTator Score 14.57
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title