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Tbio
PTCH1
Protein patched homolog 1

Protein Summary
Description
Acts as a receptor for sonic hedgehog (SHH), indian hedgehog (IHH) and desert hedgehog (DHH). Associates with the smoothened protein (SMO) to transduce the hedgehog's proteins signal. Seems to have a tumor suppressor function, as inactivation of this protein is probably a necessary, if not sufficient step for tumorigenesis. This gene encodes a member of the patched family of proteins and a component of the hedgehog signaling pathway. Hedgehog signaling is important in embryonic development and tumorigenesis. The encoded protein is the receptor for the secreted hedgehog ligands, which include sonic hedgehog, indian hedgehog and desert hedgehog. Following binding by one of the hedgehog ligands, the encoded protein is trafficked away from the primary cilium, relieving inhibition of the G-protein-coupled receptor smoothened, which results in activation of downstream signaling. Mutations of this gene have been associated with basal cell nevus syndrome and holoprosencephaly. [provided by Ref ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000331920
  • ENSP00000332353
  • ENSG00000185920
  • ENST00000375274
  • ENSP00000364423
  • ENST00000418258
  • ENSP00000396135
  • ENST00000421141
  • ENSP00000399981
  • ENST00000429896
  • ENSP00000414823
  • ENST00000430669
  • ENSP00000410287
  • ENST00000437951
  • ENSP00000389744

Symbol
  • PTCH
  • PTC
  • BCNS
  • PTC1
  • PTCH
  • NBCCS
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
1
PubMedID
0.98
transcription factor perturbation
0.97
molecular function
0.91
biological term
0.9


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1513.85   (req: < 5)
Gene RIFs: 197   (req: <= 3)
Antibodies: 609   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1513.85   (req: >= 5)
Gene RIFs: 197   (req: > 3)
Antibodies: 609   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 59
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0