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Tchem
DYRK1A
Dual specificity tyrosine-phosphorylation-regulated kinase 1A

Protein Summary
Description
Dual-specificity kinase which possesses both serine/threonine and tyrosine kinase activities. May play a role in a signaling pathway regulating nuclear functions of cell proliferation. Modulates alternative splicing by phosphorylating the splice factor SRSF6 (By similarity). Exhibits a substrate preference for proline at position P+1 and arginine at position P-3. Has pro-survival function and negatively regulates the apoptotic process. Promotes cell survival upon genotoxic stress through phosphorylation of SIRT1. This in turn inhibits TP53 activity and apoptosis (By similarity). This gene encodes a member of the Dual-specificity tyrosine phosphorylation-regulated kinase (DYRK) family. This member contains a nuclear targeting signal sequence, a protein kinase domain, a leucine zipper motif, and a highly conservative 13-consecutive-histidine repeat. It catalyzes its autophosphorylation on serine/threonine and tyrosine residues. It may play a significant role in a signaling pathway regula ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000338785
  • ENSP00000342690
  • ENSG00000157540
  • ENST00000339659
  • ENSP00000340373
  • ENST00000398956
  • ENSP00000381929
  • ENST00000398960
  • ENSP00000381932
  • ENST00000643624
  • ENSP00000493627
  • ENST00000644942
  • ENSP00000494544
  • ENST00000645424
  • ENSP00000494897
  • ENST00000646548
  • ENSP00000495908
  • ENST00000647188
  • ENSP00000494572
  • ENST00000647425
  • ENSP00000496748

Symbol
  • DYRK
  • MNB
  • MNBH
  • MNB
  • DYRK
  • HP86
  • MNBH
  • MRD7
  • DYRK1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
1
molecular function
0.98
virus perturbation
0.95
disease perturbation
0.9
transcription factor binding site profile
0.87


Related Tools
ProKinO
The ProKinO is a protein kinase-specific ontology, which provides a controlled vocabulary of terms, their hierarchy, and relationships unifying sequence, structure, function, mutation and pathway information on kinases.
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 518.55   (req: < 5)
Gene RIFs: 107   (req: <= 3)
Antibodies: 392   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 518.55   (req: >= 5)
Gene RIFs: 107   (req: > 3)
Antibodies: 392   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 29
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 70
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (14)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
eosinophil count
2
1
2
77.9
neutrophil count
2
2
2
73.6
myeloid white cell count
1
1
1
73.1
body mass index
1
1
1
57.1
mean platelet volume
1
1
1
49.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
eosinophil count
2
77.9
neutrophil count
2
73.6
myeloid white cell count
1
73.1
body mass index
1
57.1
mean platelet volume
1
49.3
Orthologs (15)
1 – 5 of 15
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
dual specificity tyrosine phosphorylation regulated kinase 1A
VGNC:7682
458545
Macaque
dual specificity tyrosine phosphorylation regulated kinase 1A
693812
Mouse
MGI:1330299
13548
Rat
RGD:2528
25255
Dog
dual specificity tyrosine phosphorylation regulated kinase 1A
VGNC:40155
487755
Species
Name
OMA
EggNOG
Inparanoid
Chimp
dual specificity tyrosine phosphorylation regulated kinase 1A
Macaque
dual specificity tyrosine phosphorylation regulated kinase 1A
Mouse
Rat
Dog
dual specificity tyrosine phosphorylation regulated kinase 1A
Protein Structure (30 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q13627-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 5 of 30
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (27)
Cell Cycle (R-HSA-1640170)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cell Cycle
Reactome
Cell Cycle, Mitotic
Reactome
G0 and Early G1
Reactome
Mitotic G1-G1/S phases
Name
Explore in Pharos
Explore in Source
Cell Cycle
Cell Cycle, Mitotic
G0 and Early G1
Mitotic G1-G1/S phases
Gene Ontology Terms (37)
Items per page:
10
1 – 10 of 12
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
MGI
Inferred from Physical Interaction (IPI)
ARUK-UCL
Inferred from Physical Interaction (IPI)
ARUK-UCL
Inferred from Physical Interaction (IPI)
IntAct
Inferred from Physical Interaction (IPI)
ARUK-UCL
Inferred from Genetic Interaction (IGI)
ARUK-UCL
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Sequence or structural Similarity (ISS)
ARUK-UCL
Traceable Author Statement (TAS)
Reactome
Protein-Protein Interactions (140)
1 – 10 of 140
CEFIP
Tdark
Novelty: 0.72318421
p_int: 0.999998062
p_ni: 0.000001938
Score: 0.873
Data Source: BioPlex,STRINGDB
FAM117B
Tdark
Novelty: 1.06316483
p_int: 0.999995395
p_ni: 0.000004605
Score: 0.564
Data Source: BioPlex,STRINGDB
DCAF7
Tbio
Novelty: 0.02609518
p_int: 0.999974073
p_ni: 0.000025927
Score: 0.983
Data Source: BioPlex,STRINGDB
FANCD2OS
Tdark
Novelty: 9.51798561
p_int: 0.999960574
p_ni: 0.000039425
Data Source: BioPlex
FNTB
Tchem
Family: Enzyme
Novelty: 0.07434994
p_int: 0.999851317
p_ni: 0.000148683
Score: 0.565
Data Source: BioPlex,STRINGDB
FAM53C
Tdark
Novelty: 1.18764113
p_int: 0.999711703
p_ni: 0.000288297
Score: 0.85
Data Source: BioPlex,STRINGDB
LZTS2
Tbio
Novelty: 0.09515452
p_int: 0.999161243
p_ni: 0.000838757
Score: 0.152
Data Source: BioPlex,STRINGDB
FNTA
Tbio
Family: Enzyme
Novelty: 0.03163169
p_int: 0.999113277
p_ni: 0.000886723
Score: 0.358
Data Source: BioPlex,STRINGDB
RAD54L2
Tdark
Family: Enzyme
Novelty: 0.26668341
p_int: 0.997312181
p_ni: 0.002687796
p_wrong: 2.3e-8
Score: 0.607
Data Source: BioPlex,STRINGDB
LRCH3
Tdark
Novelty: 1.02650989
p_int: 0.996618097
p_ni: 0.003381899
p_wrong: 4e-9
Score: 0.234
Data Source: BioPlex,STRINGDB
Publication Statistics
PubMed Score  518.55

PubMed score by year
PubTator Score  242.74

PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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