Tchem DYRK1A Dual specificity tyrosine-phosphorylation-regulated kinase 1A

Protein Summary

Description

Dual-specificity kinase which possesses both serine/threonine and tyrosine kinase activities. May play a role in a signaling pathway regulating nuclear functions of cell proliferation. Modulates alternative splicing by phosphorylating the splice factor SRSF6 (By similarity). Exhibits a substrate preference for proline at position P+1 and arginine at position P-3. Has pro-survival function and negatively regulates the apoptotic process. Promotes cell survival upon genotoxic stress through phosphorylation of SIRT1. This in turn inhibits TP53 activity and apoptosis (By similarity). This gene encodes a member of the Dual-specificity tyrosine phosphorylation-regulated kinase (DYRK) family. This member contains a nuclear targeting signal sequence, a protein kinase domain, a leucine zipper motif, and a highly conservative 13-consecutive-histidine repeat. It catalyzes its autophosphorylation on serine/threonine and tyrosine residues. It may play a significant role in a signaling pathway regulating cell proliferation and may be involved in brain development. This gene is a homolog of Drosophila mnb (minibrain) gene and rat Dyrk gene. It is localized in the Down syndrome critical region of chromosome 21, and is considered to be a strong candidate gene for learning defects associated with Down syndrome. Alternative splicing of this gene generates several transcript variants differing from each other either in the 5' UTR or in the 3' coding region. These variants encode at least five different isoforms. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• Q13627
• O60769
• Q92582
• Q92810
• Q9UNM5

Gene Name

• DYRK1A

Ensembl ID

• ENST00000338785
• ENSP00000342690
• ENSG00000157540
• ENST00000339659
• ENSP00000340373
• ENST00000398956
• ENSP00000381929
• ENST00000398960
• ENSP00000381932
• ENST00000643624
• ENSP00000493627
• ENST00000644942
• ENSP00000494544
• ENST00000645424
• ENSP00000494897
• ENST00000646548
• ENSP00000495908
• ENST00000647188
• ENSP00000494572
• ENST00000647425
• ENSP00000496748

Symbol

• DYRK
• MNB
• MNBH
• MNB
• DYRK
• HP86
• MNBH
• MRD7
• DYRK1

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
kinase perturbation	1
molecular function	0.98
virus perturbation	0.95
disease perturbation	0.9
transcription factor binding site profile	0.87

Protein Classes

PANTHER Classes

Protein / Transferase / Kinase / Protein Kinase / Non-receptor Tyrosine Protein Kinase / Dual Specificity Tyrosine-phosphorylation-regulated Kinase 1a

Protein / Transferase / Kinase / Protein Kinase / Non-receptor Serine/threonine Protein Kinase / Dual Specificity Tyrosine-phosphorylation-regulated Kinase 1a

DTO Classes

Protein / Kinase / Protein Kinase / Cmgc Group / Dyrk Family / Dyrk1 Subfamily / Dual Specificity Tyrosine-phosphorylation-regulated Kinase 1a

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 656.31   (req: < 5)

Gene RIFs: 160   (req: <= 3)

Antibodies: 392   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 656.31   (req: >= 5)

Gene RIFs: 160   (req: > 3)

Antibodies: 392   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 29

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 673

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0