Tbio TP53BP2 Apoptosis-stimulating of p53 protein 2

Protein Summary

Description

Regulator that plays a central role in regulation of apoptosis and cell growth via its interactions. Regulates TP53 by enhancing the DNA binding and transactivation function of TP53 on the promoters of proapoptotic genes in vivo. Inhibits the ability of APPBP1 to conjugate NEDD8 to CUL1, and thereby decreases APPBP1 ability to induce apoptosis. Impedes cell cycle progression at G2/M. Its apoptosis-stimulating activity is inhibited by its interaction with DDX42. This gene encodes a member of the ASPP (apoptosis-stimulating protein of p53) family of p53 interacting proteins. The protein contains four ankyrin repeats and an SH3 domain involved in protein-protein interactions. It is localized to the perinuclear region of the cytoplasm, and regulates apoptosis and cell growth through interactions with other regulatory molecules including members of the p53 family. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• Q13625
• B4DG66
• Q12892
• Q86X75
• Q96KQ3

Gene Name

• TP53BP2

Ensembl ID

• ENST00000343537
• ENSP00000341957
• ENSG00000143514
• ENST00000391878
• ENSP00000375750

Symbol

• ASPP2
• BBP
• BBP
• 53BP2
• ASPP2
• P53BP2
• PPP1R13A

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
interacting protein	0.91
virus perturbation	0.9
histone modification site profile	0.8
transcription factor binding site profile	0.78
hub protein	0.75

Protein Classes

PANTHER Classes

Protein / Enzyme Modulator / Apoptosis-stimulating Of P53 Protein 2

DTO Classes

Protein / Enzyme Modulator / Apoptosis-stimulating Of P53 Protein 2

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 110.03   (req: < 5)

Gene RIFs: 77   (req: <= 3)

Antibodies: 246   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 110.03   (req: >= 5)

Gene RIFs: 77   (req: > 3)

Antibodies: 246   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 14

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0