Protein Classes
Protein Summary
Core component of multiple cullin-RING-based E3 ubiquitin-protein ligase complexes which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. The functional specificity of the E3 ubiquitin-protein ligase complex depends on the variable substrate recognition subunit. CUL4B may act within the complex as a scaffold protein, contributing to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme. Plays a role as part of the E3 ubiquitin-protein ligase complex in polyubiquitination of CDT1, histone H2A, histone H3 and histone H4 in response to radiation-induced DNA damage. Targeted to UV damaged chromatin by DDB2 and may be important for DNA repair and DNA replication. Required for ubiquitination of cyclin E, and consequently, normal G1 cell cycle progression. Regulates the mammalian target-of-rapamycin (mTOR) pathway involved in control of cell growth, size and metabolism. Specific CUL4B regulation of the mTORC1-mediated pathway ...more
- ENST00000371322
- ENSP00000360373
- ENSG00000158290
- ENST00000404115
- ENSP00000384109
- KIAA0695
- SFM2
- MRXSC
- CUL-4B
- MRXHF2
- MRXS15
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
---|---|---|---|
transcription factor perturbation | 0.97 | ||
protein domain | 0.85 | ||
biological process | 0.71 | ||
tissue | 0.67 | ||
tissue sample | 0.67 | ||
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 63.25 (req: < 5)
Gene RIFs: 46 (req: <= 3)
Antibodies: 351 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 63.25 (req: >= 5)
Gene RIFs: 46 (req: > 3)
Antibodies: 351 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 20
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Protein Data Bank (4)
1 – 4 of 4
PDB Structure Id | Ligand | Method | Resolution (Ã…) | M.W. (kDa) | Pub Year | Title |
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PDB Structure Id | M.W. | Resolution | Pub Year |
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Pathways (56)
Reactome (15)
KEGG (3)
UniProt (1)
WikiPathways (37)
Click on a row in the table to change the structure displayed.
Items per page:
1 – 5 of 15
Data Source | Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|---|
Reactome | DNA Damage Bypass | ||||
Reactome | DNA Damage Recognition in GG-NER | ||||
Reactome | DNA Repair | ||||
Reactome | Dual Incision in GG-NER | ||||
Reactome | Dual incision in TC-NER | ||||
Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|
DNA Damage Bypass | ||||
DNA Damage Recognition in GG-NER | ||||
DNA Repair | ||||
Dual Incision in GG-NER | ||||
Dual incision in TC-NER | ||||
Gene Ontology Terms (26)
Functions (1)
Components (6)
Processes (19)
Items per page:
10
1 – 1 of 1
GO Term | Evidence | Assigned by | ||
---|---|---|---|---|
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Protein-Protein Interactions (301)
1 – 10 of 301
TRPC4AP
Novelty: 0.00440674
p_int: 0.999802604
p_ni: 0.000197396
Score: 0.92
Data Source: BioPlex,STRINGDB
DCAF4
Novelty: 0.32846715
p_int: 0.999774038
p_ni: 0.000225962
Score: 0.984
Data Source: BioPlex,STRINGDB
DDB2
Novelty: 0.00809774
p_int: 0.999747729
p_ni: 0.000252271
Score: 0.993
Data Source: BioPlex,Reactome,STRINGDB
DCAF11
Novelty: 0.12689461
p_int: 0.999727015
p_ni: 0.000272985
Score: 0.981
Data Source: BioPlex,STRINGDB
DCAF8
Novelty: 0.27272727
p_int: 0.99969849
p_ni: 0.00030151
Score: 0.946
Data Source: BioPlex,STRINGDB
GLMN
Novelty: 0.01373749
p_int: 0.999631709
p_ni: 0.000368291
Score: 0.793
Data Source: BioPlex,STRINGDB
WDTC1
Novelty: 0.00004184
p_int: 0.999613118
p_ni: 0.000386882
Score: 0.93
Data Source: BioPlex,STRINGDB
COPS8
Novelty: 0.05324769
p_int: 0.999293628
p_ni: 0.000706372
Score: 0.979
Data Source: BioPlex,STRINGDB
DCAF8L2
p_int: 0.999271641
p_ni: 0.000728359
Score: 0.158
Data Source: BioPlex,STRINGDB
DET1
Novelty: 0.01807423
p_int: 0.999108581
p_ni: 0.000891419
Score: 0.985
Data Source: BioPlex,STRINGDB
Publication Statistics
PubMed Score 63.25
PubMed score by year
PubTator Score 49.08
PubTator score by year
Amino Acid Sequence
Residue Counts
Sequence
MMSQSSGSGDGNDDEATTSKDGGFSSPSPSAAAAAQEVRSATDGNTSTTPPTSAKKRKLNSSSSSSSNSS
1-70
NEREDFDSTSSSSSTPPLQPRDSASPSTSSFCLGVSVAASSHVPIQKKLRFEDTLEFVGFDAKMAEESSS
70-140
SSSSSSPTAATSQQQQLKNKSILISSVASVHHANGLAKSSTTVSSFANSKPGSAKKLVIKNFKDKPKLPE
140-210
NYTDETWQKLKEAVEAIQNSTSIKYNLEELYQAVENLCSYKISANLYKQLRQICEDHIKAQIHQFREDSL
210-280
DSVLFLKKIDRCWQNHCRQMIMIRSIFLFLDRTYVLQNSMLPSIWDMGLELFRAHIISDQKVQNKTIDGI
280-350
LLLIERERNGEAIDRSLLRSLLSMLSDLQIYQDSFEQRFLEETNRLYAAEGQKLMQEREVPEYLHHVNKR
350-420
LEEEADRLITYLDQTTQKSLIATVEKQLLGEHLTAILQKGLNNLLDENRIQDLSLLYQLFSRVRGGVQVL
420-490
LQQWIEYIKAFGSTIVINPEKDKTMVQELLDFKDKVDHIIDICFLKNEKFINAMKEAFETFINKRPNKPA
490-560
ELIAKYVDSKLRAGNKEATDEELEKMLDKIMIIFRFIYGKDVFEAFYKKDLAKRLLVGKSASVDAEKSML
560-630
SKLKHECGAAFTSKLEGMFKDMELSKDIMIQFKQYMQNQNVPGNIELTVNILTMGYWPTYVPMEVHLPPE
630-700
MVKLQEIFKTFYLGKHSGRKLQWQSTLGHCVLKAEFKEGKKELQVSLFQTLVLLMFNEGEEFSLEEIKQA
700-770
TGIEDGELRRTLQSLACGKARVLAKNPKGKDIEDGDKFICNDDFKHKLFRIKINQIQMKETVEEQASTTE
770-840
RVFQDRQYQIDAAIVRIMKMRKTLSHNLLVSEVYNQLKFPVKPADLKKRIESLIDRDYMERDKENPNQYN
840-910
YIA
910-913
MMSQSSGSGDGNDDEATTSKDGGFSSPSPSAAAAAQEVRSATDGNTSTTPPTSAKKRKLNSSSSSSSNSSNEREDFDSTSSSSSTPPLQPRDSASPSTSSFCLGVSVAASSHVPIQKKLRFEDTLEFVGFDAKMAEESSSSSSSSSPTAATSQQQQLKNKSILISSVASVHHANGLAKSSTTVSSFANSKPGSAKKLVIKNFKDKPKLPENYTDETWQKLKEAVEAIQNSTSIKYNLEELYQAVENLCSYKISANLYKQLRQICEDHIKAQIHQFREDSLDSVLFLKKIDRCWQNHCRQMIMIRSIFLFLDRTYVLQNSMLPSIWDMGLELFRAHIISDQKVQNKTIDGILLLIERERNGEAIDRSLLRSLLSMLSDLQIYQDSFEQRFLEETNRLYAAEGQKLMQEREVPEYLHHVNKRLEEEADRLITYLDQTTQKSLIATVEKQLLGEHLTAILQKGLNNLLDENRIQDLSLLYQLFSRVRGGVQVLLQQWIEYIKAFGSTIVINPEKDKTMVQELLDFKDKVDHIIDICFLKNEKFINAMKEAFETFINKRPNKPAELIAKYVDSKLRAGNKEATDEELEKMLDKIMIIFRFIYGKDVFEAFYKKDLAKRLLVGKSASVDAEKSMLSKLKHECGAAFTSKLEGMFKDMELSKDIMIQFKQYMQNQNVPGNIELTVNILTMGYWPTYVPMEVHLPPEMVKLQEIFKTFYLGKHSGRKLQWQSTLGHCVLKAEFKEGKKELQVSLFQTLVLLMFNEGEEFSLEEIKQATGIEDGELRRTLQSLACGKARVLAKNPKGKDIEDGDKFICNDDFKHKLFRIKINQIQMKETVEEQASTTERVFQDRQYQIDAAIVRIMKMRKTLSHNLLVSEVYNQLKFPVKPADLKKRIESLIDRDYMERDKENPNQYNYIA
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