Tbio CUL4B Cullin-4B

Protein Summary

Description

Core component of multiple cullin-RING-based E3 ubiquitin-protein ligase complexes which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. The functional specificity of the E3 ubiquitin-protein ligase complex depends on the variable substrate recognition subunit. CUL4B may act within the complex as a scaffold protein, contributing to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme. Plays a role as part of the E3 ubiquitin-protein ligase complex in polyubiquitination of CDT1, histone H2A, histone H3 and histone H4 in response to radiation-induced DNA damage. Targeted to UV damaged chromatin by DDB2 and may be important for DNA repair and DNA replication. Required for ubiquitination of cyclin E, and consequently, normal G1 cell cycle progression. Regulates the mammalian target-of-rapamycin (mTOR) pathway involved in control of cell growth, size and metabolism. Specific CUL4B regulation of the mTORC1-mediated pathway is dependent upon 26S proteasome function and requires interaction between CUL4B and MLST8. This gene is a member of the cullin family. The encoded protein forms a complex that functions as an E3 ubiquitin ligase and catalyzes the polyubiquitination of specific protein substrates in the cell. The protein interacts with a ring finger protein, and is required for the proteolysis of several regulators of DNA replication including chromatin licensing and DNA replication factor 1 and cyclin E. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• Q13620
• B1APK5
• B3KVX4
• B7Z5K8
• Q6PIE4
• Q6UP07
• Q7Z673
• Q9BY37
• Q9UEB7
• Q9UED7
• CUL-4B

Gene Name

• CUL4B

Ensembl ID

• ENST00000371322
• ENSP00000360373
• ENSG00000158290
• ENST00000404115
• ENSP00000384109

Symbol

• KIAA0695
• SFM2
• MRXSC
• CUL-4B
• MRXHF2
• MRXS15

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
transcription factor perturbation	0.97
protein domain	0.85
biological process	0.71
tissue	0.67
tissue sample	0.67

Protein Classes

PANTHER Classes

Protein / Ligase / Ubiquitin-protein Ligase / Cullin-4b

DTO Classes

Protein / Enzyme / Ligase / Ubiquitin-protein Ligase / Cullin-4b

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 104.29   (req: < 5)

Gene RIFs: 46   (req: <= 3)

Antibodies: 351   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 104.29   (req: >= 5)

Gene RIFs: 46   (req: > 3)

Antibodies: 351   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 20

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Protein Sequence and Structure

Residue Counts

Protein Sequence

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Expression Data (0 Tissues)

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No expression data found

Related Tools

GENEVA

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

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GlyGen

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

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ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

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Approved Drugs (0)

No approved drugs found

Active Ligands (0)

No active ligands found

Protein-Protein Interactions (301)

Explore Interacting Targets

1 – 10 of 301

• See Interactions on String-DB

TRPC4AP

Tbio

Novelty:  0.02170224

p_int:  0.999802604

p_ni:  0.000197396

Score:  0.92

Data Source:  BioPlex,STRINGDB

DCAF4

Tbio

Novelty:  0.24190895

p_int:  0.999774038

p_ni:  0.000225962

Score:  0.984

Data Source:  BioPlex,STRINGDB

DDB2

Tbio

Novelty:  0.00648809

p_int:  0.999747729

p_ni:  0.000252271

Score:  0.993

Data Source:  BioPlex,Reactome,STRINGDB

DCAF11

Tbio

Novelty:  0.08318661

p_int:  0.999727015

p_ni:  0.000272985

Score:  0.981

Data Source:  BioPlex,STRINGDB

DCAF8

Tbio

Novelty:  0.12456534

p_int:  0.99969849

p_ni:  0.00030151

Score:  0.946

Data Source:  BioPlex,STRINGDB

GLMN

Tbio

Novelty:  0.01940401

p_int:  0.999631709

p_ni:  0.000368291

Score:  0.793

Data Source:  BioPlex,STRINGDB

WDTC1

Tbio

Novelty:  0.02300849

p_int:  0.999613118

p_ni:  0.000386882

Score:  0.93

Data Source:  BioPlex,STRINGDB

COPS8

Tbio

Novelty:  0.0408885

p_int:  0.999293628

p_ni:  0.000706372

Score:  0.979

Data Source:  BioPlex,STRINGDB

DCAF8L2

Tdark

Novelty:  6.73057868

p_int:  0.999271641

p_ni:  0.000728359

Score:  0.158

Data Source:  BioPlex,STRINGDB

DET1

Tbio

Novelty:  0.01138079

p_int:  0.999108581

p_ni:  0.000891419

Score:  0.985

Data Source:  BioPlex,STRINGDB

Nearest Tclin Targets

Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.

Pathways (56)

Reactome (15)

KEGG (3)

UniProt (1)

WikiPathways (37)

DNA Damage Bypass (R-HSA-73893)

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Data Source	Name	Explore in Pharos	Explore in Source
Reactome	DNA Damage Bypass	47 targets	R-HSA-73893
Reactome	DNA Damage Recognition in GG-NER	38 targets	R-HSA-5696394
Reactome	DNA Repair	306 targets	R-HSA-73894
Reactome	Dual Incision in GG-NER	41 targets	R-HSA-5696400
Reactome	Dual incision in TC-NER	65 targets	R-HSA-6782135

Name	Explore in Pharos	Explore in Source
DNA Damage Bypass	47 targets	R-HSA-73893
DNA Damage Recognition in GG-NER	38 targets	R-HSA-5696394
DNA Repair	306 targets	R-HSA-73894
Dual Incision in GG-NER	41 targets	R-HSA-5696400
Dual incision in TC-NER	65 targets	R-HSA-6782135

Viral Interactions (0)

No viral interactions found

Gene Ontology Terms (26)

Functions (1)

Components (6)

Processes (19)

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10

1 – 1 of 1

GO Term	Evidence	Assigned by
ubiquitin protein ligase binding	Inferred from Biological aspect of Ancestor (IBA)	GO_Central

Disease Associations ()

No disease associations found

GWAS Traits (0)

No GWAS traits found

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UniProt Keyword Find Similar Targets

No Header	No Header
3D-structure
Acetylation
Alternative splicing
Cell cycle
Complete proteome
Disease mutation
DNA damage
DNA repair
Dwarfism
Isopeptide bond

MGI Phenotype Find Similar Targets

No Header	No Header
behavior/neurological phenotype
cardiovascular system phenotype
cellular phenotype
embryo phenotype
growth/size/body region phenotype
integument phenotype
mortality/aging
nervous system phenotype

IDG Resources

No IDG generated resources found

Orthologs (14)

1 – 5 of 14

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Chimp	cullin 4B	VGNC:1397	465835
Macaque	cullin 4B		696410
Mouse	cullin 4B	MGI:1919834	72584
Rat	cullin 4B	RGD:1564494	302502
Dog	cullin 4B	VGNC:39732	492102

Species	Name	OMA	EggNOG	Inparanoid
Chimp	cullin 4B
Macaque	cullin 4B
Mouse	cullin 4B
Rat	cullin 4B
Dog	cullin 4B

Publication Statistics

PubMed Score 104.29

PubMed score by year

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PubTator Score 49.08

PubTator score by year

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Related Publications

Text Mined References (83)

GeneRif Annotations (46)

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10

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PMID	Year	Title