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Tbio
CUL4B
Cullin-4B

Protein Summary
Description
Core component of multiple cullin-RING-based E3 ubiquitin-protein ligase complexes which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. The functional specificity of the E3 ubiquitin-protein ligase complex depends on the variable substrate recognition subunit. CUL4B may act within the complex as a scaffold protein, contributing to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme. Plays a role as part of the E3 ubiquitin-protein ligase complex in polyubiquitination of CDT1, histone H2A, histone H3 and histone H4 in response to radiation-induced DNA damage. Targeted to UV damaged chromatin by DDB2 and may be important for DNA repair and DNA replication. Required for ubiquitination of cyclin E, and consequently, normal G1 cell cycle progression. Regulates the mammalian target-of-rapamycin (mTOR) pathway involved in control of cell growth, size and metabolism. Specific CUL4B regulation of the mTORC1-mediated pathway ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000371322
  • ENSP00000360373
  • ENSG00000158290
  • ENST00000404115
  • ENSP00000384109

Symbol
  • KIAA0695
  • SFM2
  • MRXSC
  • CUL-4B
  • MRXHF2
  • MRXS15
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor perturbation
0.97
protein domain
0.85
biological process
0.71
tissue
0.67
tissue sample
0.67


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 91.2   (req: < 5)
Gene RIFs: 46   (req: <= 3)
Antibodies: 351   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 91.2   (req: >= 5)
Gene RIFs: 46   (req: > 3)
Antibodies: 351   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 20
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Data Bank (4)
1 – 4 of 4
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (56)
DNA Damage Bypass (R-HSA-73893)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 15
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
DNA Damage Bypass
Reactome
DNA Damage Recognition in GG-NER
Reactome
DNA Repair
Reactome
Dual Incision in GG-NER
Reactome
Dual incision in TC-NER
Name
Explore in Pharos
Explore in Source
DNA Damage Bypass
DNA Damage Recognition in GG-NER
DNA Repair
Dual Incision in GG-NER
Dual incision in TC-NER
Gene Ontology Terms (26)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Protein-Protein Interactions (301)
1 – 10 of 301
TRPC4AP
Tbio
Novelty: 0.02170224
p_int: 0.999802604
p_ni: 0.000197396
Score: 0.92
Data Source: BioPlex,STRINGDB
DCAF4
Tbio
Novelty: 0.24190895
p_int: 0.999774038
p_ni: 0.000225962
Score: 0.984
Data Source: BioPlex,STRINGDB
DDB2
Tbio
Novelty: 0.00648809
p_int: 0.999747729
p_ni: 0.000252271
Score: 0.993
Data Source: BioPlex,Reactome,STRINGDB
DCAF11
Tbio
Novelty: 0.08318661
p_int: 0.999727015
p_ni: 0.000272985
Score: 0.981
Data Source: BioPlex,STRINGDB
DCAF8
Tbio
Novelty: 0.12456534
p_int: 0.99969849
p_ni: 0.00030151
Score: 0.946
Data Source: BioPlex,STRINGDB
GLMN
Tbio
Novelty: 0.01940401
p_int: 0.999631709
p_ni: 0.000368291
Score: 0.793
Data Source: BioPlex,STRINGDB
WDTC1
Tbio
Novelty: 0.02300849
p_int: 0.999613118
p_ni: 0.000386882
Score: 0.93
Data Source: BioPlex,STRINGDB
COPS8
Tbio
Novelty: 0.0408885
p_int: 0.999293628
p_ni: 0.000706372
Score: 0.979
Data Source: BioPlex,STRINGDB
DCAF8L2
Tdark
Novelty: 6.73057868
p_int: 0.999271641
p_ni: 0.000728359
Score: 0.158
Data Source: BioPlex,STRINGDB
DET1
Tbio
Novelty: 0.01138079
p_int: 0.999108581
p_ni: 0.000891419
Score: 0.985
Data Source: BioPlex,STRINGDB
Publication Statistics
PubMed Score  91.20

PubMed score by year
PubTator Score  49.08

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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