Protein Classes
Protein Summary
Core component of multiple cullin-RING-based E3 ubiquitin-protein ligase complexes which mediate the ubiquitination of target proteins. As a scaffold protein may contribute to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme. The E3 ubiquitin-protein ligase activity of the complex is dependent on the neddylation of the cullin subunit and is inhibited by the association of the deneddylated cullin subunit with TIP120A/CAND1. The functional specificity of the E3 ubiquitin-protein ligase complex depends on the variable substrate recognition component. DCX(DET1-COP1) directs ubiquitination of JUN. DCX(DDB2) directs ubiquitination of XPC. DCX(DDB2) ubiquitinates histones H3-H4 and is required for efficient histone deposition during replication-coupled (H3.1) and replication-independent (H3.3) nucleosome assembly, probably by facilitating the transfer of H3 from ASF1A/ASF1B to other chaperones involved in histone deposition. DCX(DTL) plays a role in PCNA-dep ...more
- ENST00000375440
- ENSP00000364589
- ENSG00000139842
- ENST00000375441
- ENSP00000364590
- ENST00000451881
- ENSP00000389118
- ENST00000617546
- ENSP00000481782
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
---|---|---|---|
virus perturbation | 0.98 | ||
transcription factor binding site profile | 0.9 | ||
biological process | 0.86 | ||
protein domain | 0.85 | ||
protein complex | 0.84 | ||
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 85.36 (req: < 5)
Gene RIFs: 85 (req: <= 3)
Antibodies: 357 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 85.36 (req: >= 5)
Gene RIFs: 85 (req: > 3)
Antibodies: 357 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 28
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Protein Data Bank (2)
1 – 2 of 2
PDB Structure Id | Ligand | Method | Resolution (Ã…) | M.W. (kDa) | Pub Year | Title |
---|
PDB Structure Id | M.W. | Resolution | Pub Year |
---|
Pathways (48)
Reactome (15)
KEGG (3)
UniProt (1)
WikiPathways (29)
Click on a row in the table to change the structure displayed.
Items per page:
1 – 5 of 15
Data Source | Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|---|
Reactome | DNA Damage Bypass | ||||
Reactome | DNA Damage Recognition in GG-NER | ||||
Reactome | DNA Repair | ||||
Reactome | Dual Incision in GG-NER | ||||
Reactome | Dual incision in TC-NER | ||||
Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|
DNA Damage Bypass | ||||
DNA Damage Recognition in GG-NER | ||||
DNA Repair | ||||
Dual Incision in GG-NER | ||||
Dual incision in TC-NER | ||||
Gene Ontology Terms (32)
Functions (1)
Components (4)
Processes (27)
Items per page:
10
1 – 1 of 1
GO Term | Evidence | Assigned by | ||
---|---|---|---|---|
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Protein-Protein Interactions (295)
1 – 10 of 295
DCAF4
Novelty: 0.32846715
p_int: 0.999929357
p_ni: 0.000070643
Score: 0.985
Data Source: BioPlex,STRINGDB
DCAF8
Novelty: 0.27272727
p_int: 0.999925487
p_ni: 0.000074513
Score: 0.934
Data Source: BioPlex,STRINGDB
DCAF11
Novelty: 0.12689461
p_int: 0.999923934
p_ni: 0.000076066
Score: 0.989
Data Source: BioPlex,STRINGDB
DDB2
Novelty: 0.00809774
p_int: 0.999896428
p_ni: 0.000103572
Score: 0.996
Data Source: BioPlex,Reactome,STRINGDB
WDTC1
Novelty: 0.00004184
p_int: 0.999891733
p_ni: 0.000108267
Score: 0.935
Data Source: BioPlex,STRINGDB
DET1
Novelty: 0.01807423
p_int: 0.999791477
p_ni: 0.000208523
Score: 0.993
Data Source: BioPlex,STRINGDB
DCAF8L2
p_int: 0.999786613
p_ni: 0.000213387
Data Source: BioPlex
TRPC4AP
Novelty: 0.00440674
p_int: 0.999678712
p_ni: 0.000321288
Score: 0.939
Data Source: BioPlex,STRINGDB
COPS8
Novelty: 0.05324769
p_int: 0.999640855
p_ni: 0.000359145
Score: 0.987
Data Source: BioPlex,STRINGDB
DTL
Novelty: 0.01976973
p_int: 0.999335019
p_ni: 0.000664981
Score: 0.992
Data Source: BioPlex,Reactome,STRINGDB
Publication Statistics
PubMed Score 85.36
PubMed score by year
PubTator Score 80.95
PubTator score by year
Amino Acid Sequence
Residue Counts
Sequence
MADEAPRKGSFSALVGRTNGLTKPAALAAAPAKPGGAGGSKKLVIKNFRDRPRLPDNYTQDTWRKLHEAV
1-70
RAVQSSTSIRYNLEELYQAVENLCSHKVSPMLYKQLRQACEDHVQAQILPFREDSLDSVLFLKKINTCWQ
70-140
DHCRQMIMIRSIFLFLDRTYVLQNSTLPSIWDMGLELFRTHIISDKMVQSKTIDGILLLIERERSGEAVD
140-210
RSLLRSLLGMLSDLQVYKDSFELKFLEETNCLYAAEGQRLMQEREVPEYLNHVSKRLEEEGDRVITYLDH
210-280
STQKPLIACVEKQLLGEHLTAILQKGLDHLLDENRVPDLAQMYQLFSRVRGGQQALLQHWSEYIKTFGTA
280-350
IVINPEKDKDMVQDLLDFKDKVDHVIEVCFQKNERFVNLMKESFETFINKRPNKPAELIAKHVDSKLRAG
350-420
NKEATDEELERTLDKIMILFRFIHGKDVFEAFYKKDLAKRLLVGKSASVDAEKSMLSKLKHECGAAFTSK
420-490
LEGMFKDMELSKDIMVHFKQHMQNQSDSGPIDLTVNILTMGYWPTYTPMEVHLTPEMIKLQEVFKAFYLG
490-560
KHSGRKLQWQTTLGHAVLKAEFKEGKKEFQVSLFQTLVLLMFNEGDGFSFEEIKMATGIEDSELRRTLQS
560-630
LACGKARVLIKSPKGKEVEDGDKFIFNGEFKHKLFRIKINQIQMKETVEEQVSTTERVFQDRQYQIDAAI
630-700
VRIMKMRKTLGHNLLVSELYNQLKFPVKPGDLKKRIESLIDRDYMERDKDNPNQYHYVA
700-759
MADEAPRKGSFSALVGRTNGLTKPAALAAAPAKPGGAGGSKKLVIKNFRDRPRLPDNYTQDTWRKLHEAVRAVQSSTSIRYNLEELYQAVENLCSHKVSPMLYKQLRQACEDHVQAQILPFREDSLDSVLFLKKINTCWQDHCRQMIMIRSIFLFLDRTYVLQNSTLPSIWDMGLELFRTHIISDKMVQSKTIDGILLLIERERSGEAVDRSLLRSLLGMLSDLQVYKDSFELKFLEETNCLYAAEGQRLMQEREVPEYLNHVSKRLEEEGDRVITYLDHSTQKPLIACVEKQLLGEHLTAILQKGLDHLLDENRVPDLAQMYQLFSRVRGGQQALLQHWSEYIKTFGTAIVINPEKDKDMVQDLLDFKDKVDHVIEVCFQKNERFVNLMKESFETFINKRPNKPAELIAKHVDSKLRAGNKEATDEELERTLDKIMILFRFIHGKDVFEAFYKKDLAKRLLVGKSASVDAEKSMLSKLKHECGAAFTSKLEGMFKDMELSKDIMVHFKQHMQNQSDSGPIDLTVNILTMGYWPTYTPMEVHLTPEMIKLQEVFKAFYLGKHSGRKLQWQTTLGHAVLKAEFKEGKKEFQVSLFQTLVLLMFNEGDGFSFEEIKMATGIEDSELRRTLQSLACGKARVLIKSPKGKEVEDGDKFIFNGEFKHKLFRIKINQIQMKETVEEQVSTTERVFQDRQYQIDAAIVRIMKMRKTLGHNLLVSELYNQLKFPVKPGDLKKRIESLIDRDYMERDKDNPNQYHYVA
Find similar targets by: