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Tchem
CUL4A
Cullin-4A

Protein Summary
Description
Core component of multiple cullin-RING-based E3 ubiquitin-protein ligase complexes which mediate the ubiquitination of target proteins. As a scaffold protein may contribute to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme. The E3 ubiquitin-protein ligase activity of the complex is dependent on the neddylation of the cullin subunit and is inhibited by the association of the deneddylated cullin subunit with TIP120A/CAND1. The functional specificity of the E3 ubiquitin-protein ligase complex depends on the variable substrate recognition component. DCX(DET1-COP1) directs ubiquitination of JUN. DCX(DDB2) directs ubiquitination of XPC. DCX(DDB2) ubiquitinates histones H3-H4 and is required for efficient histone deposition during replication-coupled (H3.1) and replication-independent (H3.3) nucleosome assembly, probably by facilitating the transfer of H3 from ASF1A/ASF1B to other chaperones involved in histone deposition. DCX(DTL) plays a role in PCNA-dep ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000375440
  • ENSP00000364589
  • ENSG00000139842
  • ENST00000375441
  • ENSP00000364590
  • ENST00000451881
  • ENSP00000389118
  • ENST00000617546
  • ENSP00000481782
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
virus perturbation
0.98
transcription factor binding site profile
0.9
biological process
0.86
protein domain
0.85
protein complex
0.84


Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 110.86   (req: < 5)
Gene RIFs: 85   (req: <= 3)
Antibodies: 357   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 110.86   (req: >= 5)
Gene RIFs: 85   (req: > 3)
Antibodies: 357   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 28
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 9
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (18)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean platelet volume
5
7
8
99.3
prothrombin time measurement
1
3
3
98
platelet count
2
3
3
95.8
factor VII measurement
1
1
1
88.6
mean corpuscular hemoglobin concentration
1
1
1
76.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean platelet volume
8
99.3
prothrombin time measurement
3
98
platelet count
3
95.8
factor VII measurement
1
88.6
mean corpuscular hemoglobin concentration
1
76.5
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
cullin 4A
VGNC:5050
107968010
Macaque
cullin 4A
714302
Mouse
MGI:1914487
99375
Rat
RGD:1563853
361181
Dog
cullin 4A
VGNC:39731
607683
Species
Name
OMA
EggNOG
Inparanoid
Chimp
cullin 4A
Macaque
cullin 4A
Mouse
Rat
Dog
cullin 4A
Protein Structure (2 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q13619-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 2 of 2
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (48)
DNA Damage Bypass (R-HSA-73893)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 15
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
DNA Damage Bypass
Reactome
DNA Damage Recognition in GG-NER
Reactome
DNA Repair
Reactome
Dual Incision in GG-NER
Reactome
Dual incision in TC-NER
Name
Explore in Pharos
Explore in Source
DNA Damage Bypass
DNA Damage Recognition in GG-NER
DNA Repair
Dual Incision in GG-NER
Dual incision in TC-NER
Gene Ontology Terms (32)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Protein-Protein Interactions (295)
1 – 10 of 295
DCAF4
Tbio
Novelty:  0.24190895
p_int:  0.999929357
p_ni:  0.000070643
Score:  0.985
Data Source:  BioPlex,STRINGDB
DCAF8
Tbio
Novelty:  0.12456534
p_int:  0.999925487
p_ni:  0.000074513
Score:  0.934
Data Source:  BioPlex,STRINGDB
DCAF11
Tbio
Novelty:  0.08318661
p_int:  0.999923934
p_ni:  0.000076066
Score:  0.989
Data Source:  BioPlex,STRINGDB
DDB2
Tbio
Novelty:  0.00648809
p_int:  0.999896428
p_ni:  0.000103572
Score:  0.996
Data Source:  BioPlex,Reactome,STRINGDB
WDTC1
Tbio
Novelty:  0.02300849
p_int:  0.999891733
p_ni:  0.000108267
Score:  0.935
Data Source:  BioPlex,STRINGDB
DET1
Tbio
Novelty:  0.01138079
p_int:  0.999791477
p_ni:  0.000208523
Score:  0.993
Data Source:  BioPlex,STRINGDB
DCAF8L2
Tdark
Novelty:  6.73057868
p_int:  0.999786613
p_ni:  0.000213387
Data Source:  BioPlex
TRPC4AP
Tbio
Novelty:  0.02170224
p_int:  0.999678712
p_ni:  0.000321288
Score:  0.939
Data Source:  BioPlex,STRINGDB
COPS8
Tbio
Novelty:  0.0408885
p_int:  0.999640855
p_ni:  0.000359145
Score:  0.987
Data Source:  BioPlex,STRINGDB
DTL
Tbio
Novelty:  0.01659105
p_int:  0.999335019
p_ni:  0.000664981
Score:  0.992
Data Source:  BioPlex,Reactome,STRINGDB
Publication Statistics
PubMed Score  110.86

PubMed score by year
PubTator Score  80.95

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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