Protein Classes
Protein Summary
Core component of multiple cullin-RING-based ECS (ElonginB/C-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complexes, which mediate the ubiquitination of target proteins. ECS complexes and ARIH1 collaborate in tandem to mediate ubiquitination of target proteins (PubMed:27565346). May serve as a rigid scaffold in the complex and may contribute to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme. The E3 ubiquitin-protein ligase activity of the complex is dependent on the neddylation of the cullin subunit and is inhibited by the association of the deneddylated cullin subunit with TIP120A/CAND1. The functional specificity of the ECS complex depends on the substrate recognition component. ECS(VHL) mediates the ubiquitination of hypoxia-inducible factor (HIF).
- ENST00000374748
- ENSP00000363880
- ENSG00000108094
- ENST00000374749
- ENSP00000363881
- ENST00000374751
- ENSP00000363883
- ENST00000421317
- ENSP00000414095
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
---|---|---|---|
disease perturbation | 0.93 | ||
interacting protein | 0.93 | ||
protein domain | 0.85 | ||
microRNA | 0.73 | ||
transcription factor | 0.71 | ||
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 112.88 (req: < 5)
Gene RIFs: 15 (req: <= 3)
Antibodies: 454 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 112.88 (req: >= 5)
Gene RIFs: 15 (req: > 3)
Antibodies: 454 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 11
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Protein Data Bank (2)
1 – 2 of 2
PDB Structure Id | Ligand | Method | Resolution (Ã…) | M.W. (kDa) | Pub Year | Title |
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PDB Structure Id | M.W. | Resolution | Pub Year |
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Pathways (53)
Reactome (15)
KEGG (4)
PathwayCommons (1)
UniProt (1)
WikiPathways (32)
Click on a row in the table to change the structure displayed.
Items per page:
1 – 5 of 15
Data Source | Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|---|
Reactome | Adaptive Immune System | ||||
Reactome | Antigen processing: Ubiquitination & Proteasome degradation | ||||
Reactome | Axon guidance | ||||
Reactome | Cellular response to hypoxia | ||||
Reactome | Cellular responses to external stimuli | ||||
Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|
Adaptive Immune System | ||||
Antigen processing: Ubiquitination & Proteasome degradation | ||||
Axon guidance | ||||
Cellular response to hypoxia | ||||
Cellular responses to external stimuli | ||||
Gene Ontology Terms (17)
Functions (2)
Components (6)
Processes (9)
Items per page:
10
1 – 2 of 2
GO Term | Evidence | Assigned by | ||
---|---|---|---|---|
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Electronic Annotation (IEA) | Ensembl | |||
Protein-Protein Interactions (455)
1 – 10 of 455
LRRC14
Novelty: 1.125
p_int: 0.999999992
p_ni: 8e-9
Score: 0.176
Data Source: BioPlex,STRINGDB
FEM1C
Novelty: 0.14895298
p_int: 0.999999973
p_ni: 2.2e-8
p_wrong: 5e-9
Score: 0.963
Data Source: BioPlex,STRINGDB
RNF187
Family: Enzyme
Novelty: 0.29411765
p_int: 0.999999341
p_ni: 6.59e-7
Data Source: BioPlex
KLHDC10
Novelty: 0.60606061
p_int: 0.999985242
p_ni: 0.000002824
p_wrong: 0.000011934
Score: 0.59
Data Source: BioPlex,STRINGDB
APPBP2
Novelty: 0.26800177
p_int: 0.999969541
p_ni: 0.000030459
Score: 0.242
Data Source: BioPlex,STRINGDB
FEM1B
Novelty: 0.07122869
p_int: 0.999965039
p_ni: 0.000034961
Score: 0.977
Data Source: BioPlex,STRINGDB
VHL
Family: Enzyme
Novelty: 0.00323188
p_int: 0.999930261
p_ni: 0.000069716
p_wrong: 2.3e-8
Score: 0.999
Data Source: BioPlex,Reactome,STRINGDB
ANKRD39
p_int: 0.999930125
p_ni: 0.000051693
p_wrong: 0.000018182
Score: 0.203
Data Source: BioPlex,STRINGDB
LRR1
Novelty: 0.04409217
p_int: 0.999923359
p_ni: 0.000075943
p_wrong: 6.98e-7
Score: 0.968
Data Source: BioPlex,STRINGDB
KLHDC3
Novelty: 0.27149321
p_int: 0.999877352
p_ni: 0.00012238
p_wrong: 2.68e-7
Score: 0.796
Data Source: BioPlex,STRINGDB
Publication Statistics
PubMed Score 112.88
PubMed score by year
PubTator Score 87.8
PubTator score by year
Amino Acid Sequence
Residue Counts
Sequence
MSLKPRVVDFDETWNKLLTTIKAVVMLEYVERATWNDRFSDIYALCVAYPEPLGERLYTETKIFLENHVR
1-70
HLHKRVLESEEQVLVMYHRYWEEYSKGADYMDCLYRYLNTQFIKKNKLTEADLQYGYGGVDMNEPLMEIG
70-140
ELALDMWRKLMVEPLQAILIRMLLREIKNDRGGEDPNQKVIHGVINSFVHVEQYKKKFPLKFYQEIFESP
140-210
FLTETGEYYKQEASNLLQESNCSQYMEKVLGRLKDEEIRCRKYLHPSSYTKVIHECQQRMVADHLQFLHA
210-280
ECHNIIRQEKKNDMANMYVLLRAVSTGLPHMIQELQNHIHDEGLRATSNLTQENMPTLFVESVLEVHGKF
280-350
VQLINTVLNGDQHFMSALDKALTSVVNYREPKSVCKAPELLAKYCDNLLKKSAKGMTENEVEDRLTSFIT
350-420
VFKYIDDKDVFQKFYARMLAKRLIHGLSMSMDSEEAMINKLKQACGYEFTSKLHRMYTDMSVSADLNNKF
420-490
NNFIKNQDTVIDLGISFQIYVLQAGAWPLTQAPSSTFAIPQELEKSVQMFELFYSQHFSGRKLTWLHYLC
490-560
TGEVKMNYLGKPYVAMVTTYQMAVLLAFNNSETVSYKELQDSTQMNEKELTKTIKSLLDVKMINHDSEKE
560-630
DIDAESSFSLNMNFSSKRTKFKITTSMQKDTPQEMEQTRSAVDEDRKMYLQAAIVRIMKARKVLRHNALI
630-700
QEVISQSRARFNPSISMIKKCIEVLIDKQYIERSQASADEYSYVA
700-745
MSLKPRVVDFDETWNKLLTTIKAVVMLEYVERATWNDRFSDIYALCVAYPEPLGERLYTETKIFLENHVRHLHKRVLESEEQVLVMYHRYWEEYSKGADYMDCLYRYLNTQFIKKNKLTEADLQYGYGGVDMNEPLMEIGELALDMWRKLMVEPLQAILIRMLLREIKNDRGGEDPNQKVIHGVINSFVHVEQYKKKFPLKFYQEIFESPFLTETGEYYKQEASNLLQESNCSQYMEKVLGRLKDEEIRCRKYLHPSSYTKVIHECQQRMVADHLQFLHAECHNIIRQEKKNDMANMYVLLRAVSTGLPHMIQELQNHIHDEGLRATSNLTQENMPTLFVESVLEVHGKFVQLINTVLNGDQHFMSALDKALTSVVNYREPKSVCKAPELLAKYCDNLLKKSAKGMTENEVEDRLTSFITVFKYIDDKDVFQKFYARMLAKRLIHGLSMSMDSEEAMINKLKQACGYEFTSKLHRMYTDMSVSADLNNKFNNFIKNQDTVIDLGISFQIYVLQAGAWPLTQAPSSTFAIPQELEKSVQMFELFYSQHFSGRKLTWLHYLCTGEVKMNYLGKPYVAMVTTYQMAVLLAFNNSETVSYKELQDSTQMNEKELTKTIKSLLDVKMINHDSEKEDIDAESSFSLNMNFSSKRTKFKITTSMQKDTPQEMEQTRSAVDEDRKMYLQAAIVRIMKARKVLRHNALIQEVISQSRARFNPSISMIKKCIEVLIDKQYIERSQASADEYSYVA
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