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Tbio
CUL2
Cullin-2

Protein Summary
Description
Core component of multiple cullin-RING-based ECS (ElonginB/C-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complexes, which mediate the ubiquitination of target proteins. ECS complexes and ARIH1 collaborate in tandem to mediate ubiquitination of target proteins (PubMed:27565346). May serve as a rigid scaffold in the complex and may contribute to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme. The E3 ubiquitin-protein ligase activity of the complex is dependent on the neddylation of the cullin subunit and is inhibited by the association of the deneddylated cullin subunit with TIP120A/CAND1. The functional specificity of the ECS complex depends on the substrate recognition component. ECS(VHL) mediates the ubiquitination of hypoxia-inducible factor (HIF).
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000374748
  • ENSP00000363880
  • ENSG00000108094
  • ENST00000374749
  • ENSP00000363881
  • ENST00000374751
  • ENSP00000363883
  • ENST00000421317
  • ENSP00000414095
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
0.93
interacting protein
0.93
protein domain
0.85
microRNA
0.73
transcription factor
0.71


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 177.54   (req: < 5)
Gene RIFs: 15   (req: <= 3)
Antibodies: 454   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 177.54   (req: >= 5)
Gene RIFs: 15   (req: > 3)
Antibodies: 454   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 11
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
eosinophil count
1
1
1
65.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
eosinophil count
1
65.4
Orthologs (15)
1 – 5 of 15
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
cullin 2
VGNC:5386
107976958
Macaque
cullin 2
698384
Mouse
MGI:1918995
71745
Rat
RGD:1310644
361258
Dog
cullin 2
VGNC:39729
477952
Species
Name
OMA
EggNOG
Inparanoid
Chimp
cullin 2
Macaque
cullin 2
Mouse
Rat
Dog
cullin 2
Protein Structure (2 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q13617-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 2 of 2
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (53)
Adaptive Immune System (R-HSA-1280218)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 15
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Adaptive Immune System
Reactome
Antigen processing: Ubiquitination & Proteasome degradation
Reactome
Axon guidance
Reactome
Cellular response to hypoxia
Reactome
Cellular responses to external stimuli
Name
Explore in Pharos
Explore in Source
Adaptive Immune System
Antigen processing: Ubiquitination & Proteasome degradation
Axon guidance
Cellular response to hypoxia
Cellular responses to external stimuli
Protein-Protein Interactions (455)
1 – 10 of 455
LRRC14
Tdark
Novelty: 0.67398865
p_int: 0.999999992
p_ni: 8e-9
Score: 0.176
Data Source: BioPlex,STRINGDB
FEM1C
Tbio
Novelty: 0.09385738
p_int: 0.999999973
p_ni: 2.2e-8
p_wrong: 5e-9
Score: 0.963
Data Source: BioPlex,STRINGDB
RNF187
Tbio
Family: Enzyme
Novelty: 0.13506464
p_int: 0.999999341
p_ni: 6.59e-7
Data Source: BioPlex
KLHDC10
Tdark
Novelty: 0.40978227
p_int: 0.999985242
p_ni: 0.000002824
p_wrong: 0.000011934
Score: 0.59
Data Source: BioPlex,STRINGDB
APPBP2
Tbio
Novelty: 0.14742368
p_int: 0.999969541
p_ni: 0.000030459
Score: 0.242
Data Source: BioPlex,STRINGDB
FEM1B
Tbio
Novelty: 0.06746412
p_int: 0.999965039
p_ni: 0.000034961
Score: 0.977
Data Source: BioPlex,STRINGDB
VHL
Tchem
Family: Enzyme
Novelty: 0.00285782
p_int: 0.999930261
p_ni: 0.000069716
p_wrong: 2.3e-8
Score: 0.999
Data Source: BioPlex,Reactome,STRINGDB
ANKRD39
Tdark
Novelty: 8.68843298
p_int: 0.999930125
p_ni: 0.000051693
p_wrong: 0.000018182
Score: 0.203
Data Source: BioPlex,STRINGDB
LRR1
Tbio
Novelty: 0.02407468
p_int: 0.999923359
p_ni: 0.000075943
p_wrong: 6.98e-7
Score: 0.968
Data Source: BioPlex,STRINGDB
KLHDC3
Tdark
Novelty: 0.63840156
p_int: 0.999877352
p_ni: 0.00012238
p_wrong: 2.68e-7
Score: 0.796
Data Source: BioPlex,STRINGDB
Publication Statistics
PubMed Score  177.54

PubMed score by year
PubTator Score  87.8

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer