Tbio CUL2 Cullin-2

Protein Classes

PANTHER Classes

Protein / Ligase / Ubiquitin-protein Ligase / Cullin-2

DTO Classes

Protein / Enzyme / Ligase / Ubiquitin-protein Ligase / Cullin-2

Protein Summary

Description

Core component of multiple cullin-RING-based ECS (ElonginB/C-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complexes, which mediate the ubiquitination of target proteins. ECS complexes and ARIH1 collaborate in tandem to mediate ubiquitination of target proteins (PubMed:27565346). May serve as a rigid scaffold in the complex and may contribute to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme. The E3 ubiquitin-protein ligase activity of the complex is dependent on the neddylation of the cullin subunit and is inhibited by the association of the deneddylated cullin subunit with TIP120A/CAND1. The functional specificity of the ECS complex depends on the substrate recognition component. ECS(VHL) mediates the ubiquitination of hypoxia-inducible factor (HIF).

Uniprot Accession IDs

• Q13617
• B3KT95
• B7Z6K8
• D3DRY6
• G3V1S2
• O00200
• Q5T2B6
• Q9UNF9
• CUL-2

Gene Name

• CUL2

Ensembl ID

• ENST00000374748
• ENSP00000363880
• ENSG00000108094
• ENST00000374749
• ENSP00000363881
• ENST00000374751
• ENSP00000363883
• ENST00000421317
• ENSP00000414095

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
disease perturbation	0.93
interacting protein	0.93
protein domain	0.85
microRNA	0.73
transcription factor	0.71

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 112.88   (req: < 5)

Gene RIFs: 15   (req: <= 3)

Antibodies: 454   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 112.88   (req: >= 5)

Gene RIFs: 15   (req: > 3)

Antibodies: 454   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 11

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Protein Data Bank (2)

1 – 2 of 2

PDB Structure Id	Ligand	Method	Resolution (Å)	M.W. (kDa)	Pub Year	Title

PDB Structure Id	M.W.	Resolution	Pub Year

Pathways (53)

Reactome (15)

KEGG (4)

PathwayCommons (1)

UniProt (1)

WikiPathways (32)

Adaptive Immune System (R-HSA-1280218)

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Items per page:

5

1 – 5 of 15

Data Source	Name	Explore in Pharos	Explore in Source
Reactome	Adaptive Immune System	894 targets	R-HSA-1280218
Reactome	Antigen processing: Ubiquitination & Proteasome degradation	307 targets	R-HSA-983168
Reactome	Axon guidance	533 targets	R-HSA-422475
Reactome	Cellular response to hypoxia	76 targets	R-HSA-1234174
Reactome	Cellular responses to external stimuli	487 targets	R-HSA-8953897

Name	Explore in Pharos	Explore in Source
Adaptive Immune System	894 targets	R-HSA-1280218
Antigen processing: Ubiquitination & Proteasome degradation	307 targets	R-HSA-983168
Axon guidance	533 targets	R-HSA-422475
Cellular response to hypoxia	76 targets	R-HSA-1234174
Cellular responses to external stimuli	487 targets	R-HSA-8953897

Gene Ontology Terms (17)

Functions (2)

Components (6)

Processes (9)

Items per page:

10

1 – 2 of 2

GO Term	Evidence	Assigned by
ubiquitin protein ligase binding	Inferred from Direct Assay (IDA)	UniProtKB
protein-containing complex binding	Inferred from Electronic Annotation (IEA)	Ensembl

Protein-Protein Interactions (455)

Explore Interacting Targets

1 – 10 of 455

• See Interactions on String-DB

LRRC14

Tdark

Novelty: 1.125

p_int: 0.999999992

p_ni: 8e-9

Score: 0.176

Data Source: BioPlex,STRINGDB

FEM1C

Tbio

Novelty: 0.14895298

p_int: 0.999999973

p_ni: 2.2e-8

p_wrong: 5e-9

Score: 0.963

Data Source: BioPlex,STRINGDB

RNF187

Tbio

Family: Enzyme

Novelty: 0.29411765

p_int: 0.999999341

p_ni: 6.59e-7

Data Source: BioPlex

KLHDC10

Tdark

Novelty: 0.60606061

p_int: 0.999985242

p_ni: 0.000002824

p_wrong: 0.000011934

Score: 0.59

Data Source: BioPlex,STRINGDB

APPBP2

Tdark

Novelty: 0.26800177

p_int: 0.999969541

p_ni: 0.000030459

Score: 0.242

Data Source: BioPlex,STRINGDB

FEM1B

Tbio

Novelty: 0.07122869

p_int: 0.999965039

p_ni: 0.000034961

Score: 0.977

Data Source: BioPlex,STRINGDB

VHL

Tchem

Family: Enzyme

Novelty: 0.00323188

p_int: 0.999930261

p_ni: 0.000069716

p_wrong: 2.3e-8

Score: 0.999

Data Source: BioPlex,Reactome,STRINGDB

ANKRD39

Tdark

p_int: 0.999930125

p_ni: 0.000051693

p_wrong: 0.000018182

Score: 0.203

Data Source: BioPlex,STRINGDB

LRR1

Tbio

Novelty: 0.04409217

p_int: 0.999923359

p_ni: 0.000075943

p_wrong: 6.98e-7

Score: 0.968

Data Source: BioPlex,STRINGDB

KLHDC3

Tdark

Novelty: 0.27149321

p_int: 0.999877352

p_ni: 0.00012238

p_wrong: 2.68e-7

Score: 0.796

Data Source: BioPlex,STRINGDB

Publication Statistics

PubMed Score  112.88

PubMed score by year

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PubTator Score  87.8

PubTator score by year

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Amino Acid Sequence

Residue Counts

Sequence

MSLKPRVVDFDETWNKLLTTIKAVVMLEYVERATWNDRFSDIYALCVAYPEPLGERLYTETKIFLENHVR

1-70

HLHKRVLESEEQVLVMYHRYWEEYSKGADYMDCLYRYLNTQFIKKNKLTEADLQYGYGGVDMNEPLMEIG

70-140

ELALDMWRKLMVEPLQAILIRMLLREIKNDRGGEDPNQKVIHGVINSFVHVEQYKKKFPLKFYQEIFESP

140-210

FLTETGEYYKQEASNLLQESNCSQYMEKVLGRLKDEEIRCRKYLHPSSYTKVIHECQQRMVADHLQFLHA

210-280

ECHNIIRQEKKNDMANMYVLLRAVSTGLPHMIQELQNHIHDEGLRATSNLTQENMPTLFVESVLEVHGKF

280-350

VQLINTVLNGDQHFMSALDKALTSVVNYREPKSVCKAPELLAKYCDNLLKKSAKGMTENEVEDRLTSFIT

350-420

VFKYIDDKDVFQKFYARMLAKRLIHGLSMSMDSEEAMINKLKQACGYEFTSKLHRMYTDMSVSADLNNKF

420-490

NNFIKNQDTVIDLGISFQIYVLQAGAWPLTQAPSSTFAIPQELEKSVQMFELFYSQHFSGRKLTWLHYLC

490-560

TGEVKMNYLGKPYVAMVTTYQMAVLLAFNNSETVSYKELQDSTQMNEKELTKTIKSLLDVKMINHDSEKE

560-630

DIDAESSFSLNMNFSSKRTKFKITTSMQKDTPQEMEQTRSAVDEDRKMYLQAAIVRIMKARKVLRHNALI

630-700

QEVISQSRARFNPSISMIKKCIEVLIDKQYIERSQASADEYSYVA

700-745

MSLKPRVVDFDETWNKLLTTIKAVVMLEYVERATWNDRFSDIYALCVAYPEPLGERLYTETKIFLENHVRHLHKRVLESEEQVLVMYHRYWEEYSKGADYMDCLYRYLNTQFIKKNKLTEADLQYGYGGVDMNEPLMEIGELALDMWRKLMVEPLQAILIRMLLREIKNDRGGEDPNQKVIHGVINSFVHVEQYKKKFPLKFYQEIFESPFLTETGEYYKQEASNLLQESNCSQYMEKVLGRLKDEEIRCRKYLHPSSYTKVIHECQQRMVADHLQFLHAECHNIIRQEKKNDMANMYVLLRAVSTGLPHMIQELQNHIHDEGLRATSNLTQENMPTLFVESVLEVHGKFVQLINTVLNGDQHFMSALDKALTSVVNYREPKSVCKAPELLAKYCDNLLKKSAKGMTENEVEDRLTSFITVFKYIDDKDVFQKFYARMLAKRLIHGLSMSMDSEEAMINKLKQACGYEFTSKLHRMYTDMSVSADLNNKFNNFIKNQDTVIDLGISFQIYVLQAGAWPLTQAPSSTFAIPQELEKSVQMFELFYSQHFSGRKLTWLHYLCTGEVKMNYLGKPYVAMVTTYQMAVLLAFNNSETVSYKELQDSTQMNEKELTKTIKSLLDVKMINHDSEKEDIDAESSFSLNMNFSSKRTKFKITTSMQKDTPQEMEQTRSAVDEDRKMYLQAAIVRIMKARKVLRHNALIQEVISQSRARFNPSISMIKKCIEVLIDKQYIERSQASADEYSYVA

Find similar targets by:

Uniprot Keyword

3D-structure
Acetylation
Alternative splicing
Complete proteome
Host-virus interaction
Isopeptide bond
Phosphoprotein
Polymorphism
Reference proteome
Ubl conjugation