Tbio CUL2 Cullin-2

Protein Summary

Description

Core component of multiple cullin-RING-based ECS (ElonginB/C-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complexes, which mediate the ubiquitination of target proteins. ECS complexes and ARIH1 collaborate in tandem to mediate ubiquitination of target proteins (PubMed:27565346). May serve as a rigid scaffold in the complex and may contribute to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme. The E3 ubiquitin-protein ligase activity of the complex is dependent on the neddylation of the cullin subunit and is inhibited by the association of the deneddylated cullin subunit with TIP120A/CAND1. The functional specificity of the ECS complex depends on the substrate recognition component. ECS(VHL) mediates the ubiquitination of hypoxia-inducible factor (HIF).

Uniprot Accession IDs

• Q13617
• B3KT95
• B7Z6K8
• D3DRY6
• G3V1S2
• O00200
• Q5T2B6
• Q9UNF9
• CUL-2

Gene Name

• CUL2

Ensembl ID

• ENST00000374748
• ENSP00000363880
• ENSG00000108094
• ENST00000374749
• ENSP00000363881
• ENST00000374751
• ENSP00000363883
• ENST00000421317
• ENSP00000414095

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
disease perturbation	0.93
interacting protein	0.93
protein domain	0.85
microRNA	0.73
transcription factor	0.71

Protein Classes

PANTHER Classes

Protein / Ligase / Ubiquitin-protein Ligase / Cullin-2

DTO Classes

Protein / Enzyme / Ligase / Ubiquitin-protein Ligase / Cullin-2

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 186.1   (req: < 5)

Gene RIFs: 15   (req: <= 3)

Antibodies: 454   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 186.1   (req: >= 5)

Gene RIFs: 15   (req: > 3)

Antibodies: 454   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 11

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Protein Sequence and Structure

Residue Counts

Protein Sequence

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Expression Data (0 Tissues)

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No expression data found

Related Tools

Target Illumination GWAS Analytics (TIGA)

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

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GENEVA

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

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GlyGen

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

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ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

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Approved Drugs (0)

No approved drugs found

Active Ligands (0)

No active ligands found

Protein-Protein Interactions (455)

Explore Interacting Targets

1 – 10 of 455

• See Interactions on String-DB

LRRC14

Tdark

Novelty:  0.67398865

p_int:  0.999999992

p_ni:  8e-9

Score:  0.176

Data Source:  BioPlex,STRINGDB

FEM1C

Tbio

Novelty:  0.09385738

p_int:  0.999999973

p_ni:  2.2e-8

p_wrong:  5e-9

Score:  0.963

Data Source:  BioPlex,STRINGDB

RNF187

Tbio

Family:  Enzyme

Novelty:  0.13506464

p_int:  0.999999341

p_ni:  6.59e-7

Data Source:  BioPlex

KLHDC10

Tdark

Novelty:  0.40978227

p_int:  0.999985242

p_ni:  0.000002824

p_wrong:  0.000011934

Score:  0.59

Data Source:  BioPlex,STRINGDB

APPBP2

Tbio

Novelty:  0.14742368

p_int:  0.999969541

p_ni:  0.000030459

Score:  0.242

Data Source:  BioPlex,STRINGDB

FEM1B

Tbio

Novelty:  0.06746412

p_int:  0.999965039

p_ni:  0.000034961

Score:  0.977

Data Source:  BioPlex,STRINGDB

VHL

Tchem

Family:  Enzyme

Novelty:  0.00285782

p_int:  0.999930261

p_ni:  0.000069716

p_wrong:  2.3e-8

Score:  0.999

Data Source:  BioPlex,Reactome,STRINGDB

ANKRD39

Tdark

Novelty:  8.68843298

p_int:  0.999930125

p_ni:  0.000051693

p_wrong:  0.000018182

Score:  0.203

Data Source:  BioPlex,STRINGDB

LRR1

Tbio

Novelty:  0.02407468

p_int:  0.999923359

p_ni:  0.000075943

p_wrong:  6.98e-7

Score:  0.968

Data Source:  BioPlex,STRINGDB

KLHDC3

Tdark

Novelty:  0.63840156

p_int:  0.999877352

p_ni:  0.00012238

p_wrong:  2.68e-7

Score:  0.796

Data Source:  BioPlex,STRINGDB

Nearest Tclin Targets

Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.

Pathways (53)

Reactome (15)

KEGG (4)

PathwayCommons (1)

UniProt (1)

WikiPathways (32)

Adaptive Immune System (R-HSA-1280218)

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5

1 – 5 of 15

Data Source	Name	Explore in Pharos	Explore in Source
Reactome	Adaptive Immune System	894 targets	R-HSA-1280218
Reactome	Antigen processing: Ubiquitination & Proteasome degradation	307 targets	R-HSA-983168
Reactome	Axon guidance	533 targets	R-HSA-422475
Reactome	Cellular response to hypoxia	76 targets	R-HSA-1234174
Reactome	Cellular responses to external stimuli	487 targets	R-HSA-8953897

Name	Explore in Pharos	Explore in Source
Adaptive Immune System	894 targets	R-HSA-1280218
Antigen processing: Ubiquitination & Proteasome degradation	307 targets	R-HSA-983168
Axon guidance	533 targets	R-HSA-422475
Cellular response to hypoxia	76 targets	R-HSA-1234174
Cellular responses to external stimuli	487 targets	R-HSA-8953897

Viral Interactions (0)

No viral interactions found

Gene Ontology Terms (17)

Functions (2)

Components (6)

Processes (9)

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Items per page:

10

1 – 2 of 2

GO Term	Evidence	Assigned by
ubiquitin protein ligase binding	Inferred from Direct Assay (IDA)	UniProtKB
protein-containing complex binding	Inferred from Electronic Annotation (IEA)	Ensembl

Disease Associations ()

No disease associations found

GWAS Traits (5)

• Explore on Target Illumination GWAS Analytics (TIGA)

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5

1 – 5 of 5

GWAS Trait	EFO ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
Crohn's disease	EFO_0000384	2	2	0	1.2	79.3
eosinophil count	EFO_0004842	2	2	2		64.3
inflammatory bowel disease	EFO_0003767	2	1	0	1.1	37.5
eosinophil percentage of leukocytes	EFO_0007991	1	1	1		12.6
ulcerative colitis	EFO_0000729	1	1	0	1.1	3.9

• Explore on Target Illumination GWAS Analytics (TIGA)

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5

1 – 5 of 5

GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
Crohn's disease	EFO_0000384	0	1.2	79.3
eosinophil count	EFO_0004842	2		64.3
inflammatory bowel disease	EFO_0003767	0	1.1	37.5
eosinophil percentage of leukocytes	EFO_0007991	1		12.6
ulcerative colitis	EFO_0000729	0	1.1	3.9

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Find similar targets by:

UniProt Keyword Find Similar Targets

No Header	No Header
3D-structure
Acetylation
Alternative splicing
Complete proteome
Host-virus interaction
Isopeptide bond
Phosphoprotein
Polymorphism
Reference proteome
Ubl conjugation

GWAS Trait Find Similar Targets

No Header	No Header
Crohn's disease
eosinophil count
eosinophil percentage of leukocytes
inflammatory bowel disease
ulcerative colitis

IDG Resources

No IDG generated resources found

Orthologs (15)

1 – 5 of 15

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Chimp	cullin 2	VGNC:5386	107976958
Macaque	cullin 2		698384
Mouse	cullin 2	MGI:1918995	71745
Rat	cullin 2	RGD:1310644	361258
Dog	cullin 2	VGNC:39729	477952

Species	Name	OMA	EggNOG	Inparanoid
Chimp	cullin 2
Macaque	cullin 2
Mouse	cullin 2
Rat	cullin 2
Dog	cullin 2

Publication Statistics

PubMed Score 186.10

PubMed score by year

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PubTator Score 87.80

PubTator score by year

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Related Publications

Text Mined References (57)

GeneRif Annotations (15)

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10

0 of 0

PMID	Year	Title