Protein Summary
Core component of multiple cullin-RING-based SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complexes, which mediate the ubiquitination of proteins involved in cell cycle progression, signal transduction and transcription. SCF complexes and ARIH1 collaborate in tandem to mediate ubiquitination of target proteins (PubMed:27565346). In the SCF complex, serves as a rigid scaffold that organizes the SKP1-F-box protein and RBX1 subunits. May contribute to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme. The E3 ubiquitin-protein ligase activity of the complex is dependent on the neddylation of the cullin subunit and exchange of the substrate recognition component is mediated by TIP120A/CAND1. The functional specificity of the SCF complex depends on the F-box protein as substrate recognition component. SCF(BTRC) and SCF(FBXW11) direct ubiquitination of CTNNB1 and participate in Wnt signaling. SCF(FBXW11) directs ubiquitination of phosphorylated N ...more
- ENST00000325222
- ENSP00000326804
- ENSG00000055130
- ENST00000409469
- ENSP00000387160
- ENST00000602748
- ENSP00000473318
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
---|---|---|---|
disease perturbation | 1 | ||
interacting protein | 0.99 | ||
kinase perturbation | 0.99 | ||
hub protein | 0.85 | ||
protein domain | 0.85 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 330.83 (req: < 5)
Gene RIFs: 58 (req: <= 3)
Antibodies: 497 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 330.83 (req: >= 5)
Gene RIFs: 58 (req: > 3)
Antibodies: 497 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 24
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
Related Tools

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GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (651)
FBXO42
Novelty: 0.17658866
p_int: 0.999679246
p_ni: 0.000320754
Score: 0.617
Data Source: BioPlex,STRINGDB
FBXL15
Novelty: 0.18567032
p_int: 0.999656393
p_ni: 0.000343607
Score: 0.975
Data Source: BioPlex,STRINGDB
FBXO4
Novelty: 0.06891705
p_int: 0.999442546
p_ni: 0.000557454
Score: 0.971
Data Source: BioPlex,STRINGDB
FBXO40
Novelty: 0.20308726
p_int: 0.99895066
p_ni: 0.00104934
Score: 0.951
Data Source: BioPlex,STRINGDB
FBXO6
Novelty: 0.02173918
p_int: 0.998923168
p_ni: 0.001076832
Score: 0.972
Data Source: BioPlex,STRINGDB
FBXO7
Novelty: 0.01151907
p_int: 0.998876399
p_ni: 0.001123601
Score: 0.974
Data Source: BioPlex,STRINGDB
FBXL5
Novelty: 0.03103624
p_int: 0.998777197
p_ni: 0.001222803
Score: 0.971
Data Source: BioPlex,Reactome,STRINGDB
FBXO17
Novelty: 0.1320754
p_int: 0.99457516
p_ni: 0.005424834
p_wrong: 6e-9
Score: 0.969
Data Source: BioPlex,STRINGDB
FBXO44
Novelty: 0.06669582
p_int: 0.994169232
p_ni: 0.005830768
Score: 0.967
Data Source: BioPlex,STRINGDB
CRY1
Novelty: 0.00116593
p_int: 0.993853774
p_ni: 0.006146226
Score: 0.583
Data Source: BioPlex,STRINGDB
Nearest Tclin Targets
Pathways (133)
Reactome (96)
KEGG (10)
PathwayCommons (18)
UniProt (1)
WikiPathways (8)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|---|
Reactome | APC/C-mediated degradation of cell cycle proteins | ||||
Reactome | Activation of NF-kappaB in B cells | ||||
Reactome | Adaptive Immune System | ||||
Reactome | Antigen processing: Ubiquitination & Proteasome degradation | ||||
Reactome | C-type lectin receptors (CLRs) | ||||
Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|
APC/C-mediated degradation of cell cycle proteins | ||||
Activation of NF-kappaB in B cells | ||||
Adaptive Immune System | ||||
Antigen processing: Ubiquitination & Proteasome degradation | ||||
C-type lectin receptors (CLRs) | ||||
Viral Interactions (0)
Gene Ontology Terms (29)
Functions (2)
Components (5)
Processes (22)
GO Term | Evidence | Assigned by | ||
---|---|---|---|---|
Inferred from Experiment (EXP) | Reactome | |||
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Disease Associations ()
GWAS Traits (6)
Items per page:
1 – 5 of 6
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|---|---|
mean corpuscular hemoglobin concentration | 1 | 1 | 1 | 65.4 | |||||
1 | 1 | 0 | 1.1 | 40.7 | |||||
mean corpuscular volume | 1 | 1 | 1 | 35 | |||||
mean reticulocyte volume | 1 | 1 | 1 | 30.2 | |||||
1 | 1 | 1 | 14.2 | ||||||
Items per page:
1 – 5 of 6
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|
mean corpuscular hemoglobin concentration | 1 | 65.4 | |||||
0 | 1.1 | 40.7 | |||||
mean corpuscular volume | 1 | 35 | |||||
mean reticulocyte volume | 1 | 30.2 | |||||
1 | 14.2 | ||||||
Find similar targets by:
IDG Resources
Orthologs (16)
1 – 5 of 16
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|---|---|
Chimp | cullin 1 | VGNC:4326 | 463821 | |||||
Macaque | cullin 1 | 710581 | ||||||
Mouse | MGI:1349658 | 26965 | ||||||
Rat | RGD:1308157 | 362356 | ||||||
Dog | cullin 1 | VGNC:39728 | 475512 | |||||
Publication Statistics
PubMed Score 330.83
PubMed score by year
PubTator Score 196.65
PubTator score by year
Related Publications
Text Mined References (153)
GeneRif Annotations (58)
Items per page:
0 of 0
PMID | Year | Title |
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