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Tbio
CUL1
Cullin-1

Protein Summary
Description
Core component of multiple cullin-RING-based SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complexes, which mediate the ubiquitination of proteins involved in cell cycle progression, signal transduction and transcription. SCF complexes and ARIH1 collaborate in tandem to mediate ubiquitination of target proteins (PubMed:27565346). In the SCF complex, serves as a rigid scaffold that organizes the SKP1-F-box protein and RBX1 subunits. May contribute to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme. The E3 ubiquitin-protein ligase activity of the complex is dependent on the neddylation of the cullin subunit and exchange of the substrate recognition component is mediated by TIP120A/CAND1. The functional specificity of the SCF complex depends on the F-box protein as substrate recognition component. SCF(BTRC) and SCF(FBXW11) direct ubiquitination of CTNNB1 and participate in Wnt signaling. SCF(FBXW11) directs ubiquitination of phosphorylated N ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000325222
  • ENSP00000326804
  • ENSG00000055130
  • ENST00000409469
  • ENSP00000387160
  • ENST00000602748
  • ENSP00000473318
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
1
interacting protein
0.99
kinase perturbation
0.99
hub protein
0.85
protein domain
0.85


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
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GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 322.63   (req: < 5)
Gene RIFs: 58   (req: <= 3)
Antibodies: 497   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 322.63   (req: >= 5)
Gene RIFs: 58   (req: > 3)
Antibodies: 497   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 24
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (3)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean corpuscular hemoglobin concentration
1
1
1
67.6
1
1
1
33.9
1
1
0
1.1
25.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean corpuscular hemoglobin concentration
1
67.6
1
33.9
0
1.1
25.3
Orthologs (16)
1 – 5 of 16
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
cullin 1
VGNC:4326
463821
Macaque
cullin 1
710581
Mouse
MGI:1349658
26965
Rat
RGD:1308157
362356
Dog
cullin 1
VGNC:39728
475512
Species
Name
OMA
EggNOG
Inparanoid
Chimp
cullin 1
Macaque
cullin 1
Mouse
Rat
Dog
cullin 1
Protein Structure (9 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q13616-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 5 of 9
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (133)
APC/C-mediated degradation of cell cycle proteins (R-HSA-174143)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 96
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
APC/C-mediated degradation of cell cycle proteins
Reactome
Activation of NF-kappaB in B cells
Reactome
Adaptive Immune System
Reactome
Antigen processing: Ubiquitination & Proteasome degradation
Reactome
C-type lectin receptors (CLRs)
Name
Explore in Pharos
Explore in Source
APC/C-mediated degradation of cell cycle proteins
Activation of NF-kappaB in B cells
Adaptive Immune System
Antigen processing: Ubiquitination & Proteasome degradation
C-type lectin receptors (CLRs)
Protein-Protein Interactions (651)
1 – 10 of 651
FBXO42
Tbio
Novelty: 0.17658866
p_int: 0.999679246
p_ni: 0.000320754
Score: 0.617
Data Source: BioPlex,STRINGDB
FBXL15
Tbio
Novelty: 0.18567032
p_int: 0.999656393
p_ni: 0.000343607
Score: 0.975
Data Source: BioPlex,STRINGDB
FBXO4
Tbio
Novelty: 0.06891705
p_int: 0.999442546
p_ni: 0.000557454
Score: 0.971
Data Source: BioPlex,STRINGDB
FBXO40
Tbio
Novelty: 0.20308726
p_int: 0.99895066
p_ni: 0.00104934
Score: 0.951
Data Source: BioPlex,STRINGDB
FBXO6
Tbio
Novelty: 0.02173918
p_int: 0.998923168
p_ni: 0.001076832
Score: 0.972
Data Source: BioPlex,STRINGDB
FBXO7
Tbio
Novelty: 0.01151907
p_int: 0.998876399
p_ni: 0.001123601
Score: 0.974
Data Source: BioPlex,STRINGDB
FBXL5
Tbio
Novelty: 0.03103624
p_int: 0.998777197
p_ni: 0.001222803
Score: 0.971
Data Source: BioPlex,Reactome,STRINGDB
FBXO17
Tbio
Novelty: 0.1320754
p_int: 0.99457516
p_ni: 0.005424834
p_wrong: 6e-9
Score: 0.969
Data Source: BioPlex,STRINGDB
FBXO44
Tbio
Novelty: 0.06669582
p_int: 0.994169232
p_ni: 0.005830768
Score: 0.967
Data Source: BioPlex,STRINGDB
CRY1
Tchem
Novelty: 0.00116593
p_int: 0.993853774
p_ni: 0.006146226
Score: 0.583
Data Source: BioPlex,STRINGDB
Publication Statistics
PubMed Score  322.63

PubMed score by year
PubTator Score  196.65

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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