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Tbio
MTMR3
Myotubularin-related protein 3

Protein Summary
Description
Phosphatase that acts on lipids with a phosphoinositol headgroup. Has phosphatase activity towards phosphatidylinositol 3-phosphate and phosphatidylinositol 3,5-bisphosphate. May also dephosphorylate proteins phosphorylated on Ser, Thr, and Tyr residues (PubMed:10733931). This gene encodes a member of the myotubularin dual specificity protein phosphatase gene family. The encoded protein is structurally similar to myotubularin but in addition contains a FYVE domain and an N-terminal PH-GRAM domain. The protein can self-associate and also form heteromers with another myotubularin related protein. The protein binds to phosphoinositide lipids through the PH-GRAM domain, and can hydrolyze phosphatidylinositol(3)-phosphate and phosphatidylinositol(3,5)-biphosphate in vitro. The encoded protein has been observed to have a perinuclear, possibly membrane-bound, distribution in cells, but it has also been found free in the cytoplasm. Multiple transcript variants encoding different isoforms have ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000333027
  • ENSP00000331649
  • ENSG00000100330
  • ENST00000351488
  • ENSP00000307271
  • ENST00000401950
  • ENSP00000384651
  • ENST00000406629
  • ENSP00000384077

Symbol
  • KIAA0371
  • ZFYVE10
  • ZFYVE10
  • FYVE-DSP1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.92
transcription factor perturbation
0.88
disease perturbation
0.87
microRNA
0.82
kinase perturbation
0.76


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 22.2   (req: < 5)
Gene RIFs: 14   (req: <= 3)
Antibodies: 54   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 22.2   (req: >= 5)
Gene RIFs: 14   (req: > 3)
Antibodies: 54   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 14
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (67)
IL10
Tbio
Novelty:  0.00004352
p_int:  0.999900584
p_ni:  0.000072577
p_wrong:  0.000026839
Data Source:  BioPlex
MED18
Tbio
Family:  Enzyme
Novelty:  0.04066825
p_int:  0.999606556
p_ni:  0.000393444
Data Source:  BioPlex
AURKA
Tchem
Family:  Kinase
Novelty:  0.0010868
p_int:  0.999515137
p_ni:  0.000484863
Data Source:  BioPlex
PNO1
Tbio
Novelty:  0.05311566
p_int:  0.996974484
p_ni:  0.003025516
Score:  0.252
Data Source:  BioPlex,STRINGDB
GTF3C4
Tdark
Family:  Epigenetic
Novelty:  0.28198123
p_int:  0.988235785
p_ni:  0.01176421
p_wrong:  5e-9
Data Source:  BioPlex
ALOX5
Tclin
Family:  Enzyme
Novelty:  0.00062988
p_int:  0.98048061
p_ni:  0.01951939
Data Source:  BioPlex
HDAC11
Tclin
Family:  Epigenetic
Novelty:  0.01015211
p_int:  0.957966363
p_ni:  0.042033637
Score:  0.183
Data Source:  BioPlex,STRINGDB
TULP3
Tbio
Family:  TF
Novelty:  0.06911636
p_int:  0.933898072
p_ni:  0.066101928
Score:  0.166
Data Source:  BioPlex,STRINGDB
DNAJC10
Tbio
Novelty:  0.02258366
p_int:  0.891241488
p_ni:  0.108758512
Score:  0.163
Data Source:  BioPlex,STRINGDB
PIKFYVE
Tchem
Family:  Kinase
Novelty:  0.00441336
Score:  0.93
Data Source:  STRINGDB
Nearest Tclin Targets (5)
Explore Nearest Tclin Targets
Pathways (15)
Autophagy (R-HSA-9612973)

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Find Similar Targets
Items per page:
1 – 5 of 8
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Autophagy
Reactome
Cellular responses to external stimuli
Reactome
Macroautophagy
Reactome
Metabolism
Reactome
Metabolism of lipids
Name
Explore in Pharos
Explore in Source
Autophagy
Cellular responses to external stimuli
Macroautophagy
Metabolism
Metabolism of lipids
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (18)
Find Similar Targets
Items per page:
10
1 – 6 of 6
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Disease Associations ()
No disease associations found
GWAS Traits (34)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
tonsillectomy risk measurement
2
2
0
1.2
90.9
serum non-albumin protein measurement
1
2
2
90.6
blood protein measurement
1
2
2
84.3
mean corpuscular hemoglobin concentration
1
1
1
82.8
reticulocyte count
3
3
3
82.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
tonsillectomy risk measurement
0
1.2
90.9
serum non-albumin protein measurement
2
90.6
blood protein measurement
2
84.3
mean corpuscular hemoglobin concentration
1
82.8
reticulocyte count
3
82.8
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
myotubularin related protein 3
VGNC:5284
458748
Macaque
myotubularin related protein 3
715214
Mouse
MGI:1921552
74302
Rat
RGD:1310972
305482
Dog
myotubularin related protein 3
VGNC:43484
100856311
Species
Name
OMA
EggNOG
Inparanoid
Chimp
myotubularin related protein 3
Macaque
myotubularin related protein 3
Mouse
Rat
Dog
myotubularin related protein 3
Publication Statistics
PubMed Score 22.20
PubMed score by year
PubTator Score 15.04
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title