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Tbio
MTMR1
Myotubularin-related protein 1

Protein Summary
Description
Lipid phosphatase that has high specificity for phosphatidylinositol 3-phosphate and has no activity with phosphatidylinositol 4-phosphate, phosphatidylinositol (4,5)-bisphosphate and phosphatidylinositol (3,4,5)-trisphosphate (PubMed:11733541, PubMed:27018598). Activity with phosphatidylinositol (3,5)-bisphosphate is controversial; it has been shown by PubMed:27018598, while PubMed:11733541 find no activity with this substrate. This gene encodes a member of the myotubularin related family of proteins. Members of this family contain the consensus sequence for the active site of protein tyrosine phosphatases. Alternatively spliced variants have been described but their biological validity has not been determined. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000370390
  • ENSP00000359417
  • ENSG00000063601
  • ENST00000485376
  • ENSP00000434105
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.85
disease perturbation
0.74
histone modification site profile
0.74
transcription factor perturbation
0.68
kinase perturbation
0.66


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 11.67   (req: < 5)
Gene RIFs: 3   (req: <= 3)
Antibodies: 94   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 11.67   (req: >= 5)
Gene RIFs: 3   (req: > 3)
Antibodies: 94   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (81)
GMNN
Tbio
Novelty:  0.00436572
p_int:  0.999986361
p_ni:  0.000013639
Data Source:  BioPlex
RPGR
Tbio
Family:  Enzyme
Novelty:  0.002733
p_int:  0.998002823
p_ni:  0.001997177
Score:  0.186
Data Source:  BioPlex,STRINGDB
TRIM10
Tbio
Novelty:  0.27685659
p_int:  0.992410516
p_ni:  0.007589484
Score:  0.183
Data Source:  BioPlex,STRINGDB
LIPC
Tchem
Family:  Enzyme
Novelty:  0.00219107
p_int:  0.975489373
p_ni:  0.024510627
Score:  0.319
Data Source:  BioPlex,STRINGDB
RAB6B
Tbio
Family:  Enzyme
Novelty:  0.0865097
p_int:  0.963292289
p_ni:  0.036707711
Score:  0.154
Data Source:  BioPlex,STRINGDB
HAVCR2
Tbio
Novelty:  0.00155885
p_int:  0.96302693
p_ni:  0.03697307
Data Source:  BioPlex
EFNB2
Tbio
Novelty:  0.00255095
p_int:  0.939838706
p_ni:  0.060161294
Data Source:  BioPlex
PSMC2
Tbio
Family:  Enzyme
Novelty:  0.08240664
p_int:  0.9292643
p_ni:  0.070735664
p_wrong:  3.7e-8
Score:  0.215
Data Source:  BioPlex,STRINGDB
PIP4K2A
Tbio
Family:  Kinase
Novelty:  0.01130885
p_int:  0.904356025
p_ni:  0.095638762
p_wrong:  0.000005213
Score:  0.706
Data Source:  BioPlex,STRINGDB
SKAP1
Tbio
Family:  Enzyme
Novelty:  0.03753848
p_int:  0.860088631
p_ni:  0.139911366
p_wrong:  3e-9
Data Source:  BioPlex
Nearest Tclin Targets (5)
Explore Nearest Tclin Targets
Pathways (9)
Metabolism (R-HSA-1430728)

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Find Similar Targets
Items per page:
1 – 5 of 5
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Metabolism
Reactome
Metabolism of lipids
Reactome
PI Metabolism
Reactome
Phospholipid metabolism
Reactome
Synthesis of PIPs at the plasma membrane
Name
Explore in Pharos
Explore in Source
Metabolism
Metabolism of lipids
PI Metabolism
Phospholipid metabolism
Synthesis of PIPs at the plasma membrane
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (10)
Find Similar Targets
Items per page:
10
1 – 4 of 4
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Electronic Annotation (IEA)
InterPro
Disease Associations ()
No disease associations found
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean platelet volume
1
1
1
56.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean platelet volume
1
56.6
IDG Resources
No IDG generated resources found
Orthologs (15)
1 – 5 of 15
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
myotubularin related protein 1
VGNC:2697
465905
Macaque
myotubularin related protein 1
708892
Mouse
MGI:1858271
53332
Rat
RGD:1306569
317296
Dog
myotubularin related protein 1
VGNC:43478
492211
Species
Name
OMA
EggNOG
Inparanoid
Chimp
myotubularin related protein 1
Macaque
myotubularin related protein 1
Mouse
Rat
Dog
myotubularin related protein 1
Publication Statistics
PubMed Score 11.67
PubMed score by year
PubTator Score 8.52
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title