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Tbio
DNASE1L3
Deoxyribonuclease gamma

Protein Summary
Description
Has DNA hydrolytic activity. Is capable of both single- and double-stranded DNA cleavage, producing DNA fragments with 3'-OH ends (By similarity). Can cleave chromatin to nucleosomal units and cleaves nucleosomal and liposome-coated DNA (PubMed:9070308, PubMed:9714828, PubMed:14646506, PubMed:10807908, PubMed:27293190). Acts in internucleosomal DNA fragmentation (INDF) during apoptosis and necrosis (PubMed:23229555, PubMed:24312463). The role in apoptosis includes myogenic and neuronal differentiation, and BCR-mediated clonal deletion of self-reactive B cells (By similarity). Is active on chromatin in apoptotic cell-derived membrane-coated microparticles and thus suppresses anti-DNA autoimmunity (PubMed:27293190). Together with DNASE1, plays a key role in degrading neutrophil extracellular traps (NETs) (By similarity). NETs are mainly composed of DNA fibers and are released by neutrophils to bind pathogens during inflammation (By similarity). Degradation of intravascular NETs by DNASE1 ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000394549
  • ENSP00000378053
  • ENSG00000163687
  • ENST00000486455
  • ENSP00000419052

Symbol
  • DHP2
  • DNAS1L3
  • LSD
  • DHP2
  • SLEB16
  • DNAS1L3
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.67
tissue
0.54
cell type or tissue
0.48
transcription factor
0.48
tissue sample
0.47


Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 90.29   (req: < 5)
Gene RIFs: 17   (req: <= 3)
Antibodies: 185   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 90.29   (req: >= 5)
Gene RIFs: 17   (req: > 3)
Antibodies: 185   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 12
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (10)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
3
1
0
1.5
80.2
1
1
0
1.6
73
lymphocyte count
1
1
1
46.1
BMI-adjusted waist circumference
1
1
1
40.7
waist circumference
1
1
1
33.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
1.5
80.2
0
1.6
73
lymphocyte count
1
46.1
BMI-adjusted waist circumference
1
40.7
waist circumference
1
33.1
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
deoxyribonuclease 1 like 3
702613
Mouse
MGI:1314633
13421
Rat
RGD:620669
116687
Dog
deoxyribonuclease 1 like 3
VGNC:40025
476576
Horse
deoxyribonuclease 1 like 3
VGNC:17247
100057863
Species
Name
OMA
EggNOG
Inparanoid
Macaque
deoxyribonuclease 1 like 3
Mouse
Rat
Dog
deoxyribonuclease 1 like 3
Horse
deoxyribonuclease 1 like 3
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q13609-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Gene Ontology Terms (15)
Items per page:
10
1 – 4 of 4
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Traceable Author Statement (TAS)
ProtInc
Protein-Protein Interactions (19)
1 – 10 of 19
NRAC
Tbio
Novelty:  0.16564395
Score:  0.621
Data Source:  STRINGDB
PXK
Tbio
Family:  Kinase
Novelty:  0.02316511
Score:  0.577
Data Source:  STRINGDB
DNASE2
Tbio
Family:  Enzyme
Novelty:  0.01869454
Score:  0.569
Data Source:  STRINGDB
DFFB
Tbio
Novelty:  0.00475349
Score:  0.559
Data Source:  STRINGDB
INSR
Tclin
Family:  Kinase
Novelty:  0.00230617
Score:  0.539
Data Source:  STRINGDB
CLEC10A
Tbio
Novelty:  0.00656565
Score:  0.499
Data Source:  STRINGDB
ASGR1
Tbio
Novelty:  0.00209845
Score:  0.478
Data Source:  STRINGDB
SCHIP1
Tbio
Novelty:  0.0765945
Score:  0.473
Data Source:  STRINGDB
GCFC2
Tbio
Novelty:  0.04245608
Score:  0.456
Data Source:  STRINGDB
ALB
Tchem
Novelty:  0.00000616
Score:  0.451
Data Source:  STRINGDB
Publication Statistics
PubMed Score  90.29

PubMed score by year
PubTator Score  57.14

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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