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Tbio
KRR1
KRR1 small subunit processome component homolog

Protein Summary
Description
Required for 40S ribosome biogenesis. Involved in nucleolar processing of pre-18S ribosomal RNA and ribosome assembly (By similarity).
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000229214
  • ENSP00000229214
  • ENSG00000111615
  • ENST00000438169
  • ENSP00000411740

Symbol
  • HRB2
  • HRB2
  • RIP-1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
virus perturbation
1
co-expressed gene
0.99
ligand (protein) perturbation
0.96
transcription factor binding site profile
0.89
transcription factor perturbation
0.84


Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 14.65   (req: < 5)
Gene RIFs: 4   (req: <= 3)
Antibodies: 165   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 14.65   (req: >= 5)
Gene RIFs: 4   (req: > 3)
Antibodies: 165   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
2
2
1
1.1
34.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
1
1.1
34.7
Orthologs (15)
1 – 5 of 15
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
KRR1, small subunit processome component homolog
VGNC:10079
452081
Macaque
KRR1, small subunit processome component homolog
718935
Mouse
MGI:1289274
52705
Rat
RGD:1306183
314830
Dog
KRR1 small subunit processome component homolog
475405
Species
Name
OMA
EggNOG
Inparanoid
Chimp
KRR1, small subunit processome component homolog
Macaque
KRR1, small subunit processome component homolog
Mouse
Rat
Dog
KRR1 small subunit processome component homolog
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q13601-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (5)
Major pathway of rRNA processing in the nucleolus and cytosol (R-HSA-6791226)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 5
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Major pathway of rRNA processing in the nucleolus and cytosol
Reactome
Metabolism of RNA
Reactome
rRNA modification in the nucleus and cytosol
Reactome
rRNA processing
Reactome
rRNA processing in the nucleus and cytosol
Name
Explore in Pharos
Explore in Source
Major pathway of rRNA processing in the nucleolus and cytosol
Metabolism of RNA
rRNA modification in the nucleus and cytosol
rRNA processing
rRNA processing in the nucleus and cytosol
Gene Ontology Terms (9)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from High Throughput Direct Assay (HDA)
UniProtKB
Protein-Protein Interactions (325)
1 – 10 of 325
HIST1H1T
Tdark
Novelty:  0.01039464
p_int:  0.978719593
p_ni:  0.021280407
Score:  0.356
Data Source:  BioPlex,STRINGDB
HIST1H1E
Tbio
Novelty:  0.01125284
p_int:  0.975648567
p_ni:  0.024351433
Score:  0.221
Data Source:  BioPlex,STRINGDB
RPS14
Tbio
Novelty:  0.00576737
p_int:  0.97410418
p_ni:  0.02589582
Score:  0.989
Data Source:  BioPlex,STRINGDB
RPS2
Tbio
Novelty:  0.00412313
p_int:  0.964469154
p_ni:  0.035530846
Score:  0.966
Data Source:  BioPlex,STRINGDB
RPS13
Tbio
Novelty:  0.0019983
p_int:  0.961580052
p_ni:  0.038419948
p_wrong:  1e-9
Score:  0.985
Data Source:  BioPlex,STRINGDB
THAP3
Tdark
Family:  TF
Novelty:  0.52942342
p_int:  0.930422036
p_ni:  0.069577964
Data Source:  BioPlex
H2AFX
Tbio
Novelty:  0.00048694
p_int:  0.924188354
p_ni:  0.075811646
Score:  0.194
Data Source:  BioPlex,STRINGDB
DAXX
Tbio
Novelty:  0.00348585
p_int:  0.890405597
p_ni:  0.109594381
p_wrong:  2.1e-8
Data Source:  BioPlex
RPS16
Tbio
Novelty:  0.00261983
p_int:  0.885390864
p_ni:  0.114609136
Score:  0.978
Data Source:  BioPlex,STRINGDB
RPL23A
Tbio
Novelty:  0.02951947
p_int:  0.876543391
p_ni:  0.123456609
Score:  0.281
Data Source:  BioPlex,STRINGDB
Publication Statistics
PubMed Score  14.65

PubMed score by year
PubTator Score  5.62

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer