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Tbio
SNX1
Sorting nexin-1

Protein Summary
Description
Involved in several stages of intracellular trafficking. Interacts with membranes containing phosphatidylinositol 3-phosphate (PtdIns(3P)) or phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2) (PubMed:12198132). Acts in part as component of the retromer membrane-deforming SNX-BAR subcomplex. The SNX-BAR retromer mediates retrograde transport of cargo proteins from endosomes to the trans-Golgi network (TGN) and is involved in endosome-to-plasma membrane transport for cargo protein recycling. The SNX-BAR subcomplex functions to deform the donor membrane into a tubular profile called endosome-to-TGN transport carrier (ETC) (Probable). Can sense membrane curvature and has in vitro vesicle-to-membrane remodeling activity (PubMed:19816406, PubMed:23085988). Involved in retrograde endosome-to-TGN transport of lysosomal enzyme receptors (IGF2R, M6PR and SORT1) and Shiginella dysenteria toxin stxB. Plays a role in targeting ligand-activated EGFR to the lysosomes for degradation after endocyt ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000261889
  • ENSP00000261889
  • ENSG00000028528
  • ENST00000559844
  • ENSP00000453785
  • ENST00000561026
  • ENSP00000453567

Symbol
  • VPS5
  • HsT17379
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
1
kinase perturbation
0.97
interacting protein
0.89
transcription factor perturbation
0.88
transcription factor binding site profile
0.83


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IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 90.42   (req: < 5)
Gene RIFs: 23   (req: <= 3)
Antibodies: 337   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 90.42   (req: >= 5)
Gene RIFs: 23   (req: > 3)
Antibodies: 337   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 15
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
sorting nexin 1
VGNC:1875
453503
Macaque
sorting nexin 1
706544
Mouse
MGI:1928395
56440
Rat
RGD:68935
84471
Dog
sorting nexin 1
VGNC:46619
478336
Species
Name
OMA
EggNOG
Inparanoid
Chimp
sorting nexin 1
Macaque
sorting nexin 1
Mouse
Rat
Dog
sorting nexin 1
Protein Data Bank (2)
1 – 2 of 2
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Gene Ontology Terms (29)
Items per page:
10
1 – 9 of 9
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
IntAct
Inferred from Physical Interaction (IPI)
ParkinsonsUK-UCL
Inferred from Physical Interaction (IPI)
ParkinsonsUK-UCL
Inferred from High Throughput Direct Assay (HDA)
BHF-UCL
Protein-Protein Interactions (137)
1 – 10 of 137
SNX32
Tdark
Novelty: 0.66136036
p_int: 1
Score: 0.772
Data Source: BioPlex,STRINGDB
SNX5
Tbio
Novelty: 0.04075649
p_int: 0.999999997
p_ni: 3e-9
Score: 0.996
Data Source: BioPlex,STRINGDB
SNX6
Tbio
Novelty: 0.05909848
p_int: 0.999999953
p_ni: 4.3e-8
p_wrong: 4e-9
Score: 0.991
Data Source: BioPlex,STRINGDB
BIN3
Tbio
Novelty: 0.02034119
p_int: 0.999999939
p_ni: 6.1e-8
Score: 0.336
Data Source: BioPlex,STRINGDB
SNX2
Tbio
Novelty: 0.03880384
p_int: 0.999997789
p_ni: 0.000002211
Score: 0.976
Data Source: BioPlex,STRINGDB
C1orf87
Tbio
Novelty: 0.03162594
p_int: 0.999995777
p_ni: 0.000004223
Score: 0.538
Data Source: BioPlex,STRINGDB
KLHL1
Tbio
Novelty: 0.05206893
p_int: 0.999995197
p_ni: 0.000004802
Data Source: BioPlex
CCDC102B
Tdark
Novelty: 0.28075569
p_int: 0.999761369
p_ni: 0.000238631
Data Source: BioPlex
HYOU1
Tbio
Novelty: 0.00833649
p_int: 0.999752857
p_ni: 0.000247142
p_wrong: 1e-9
Data Source: BioPlex
LRRC61
Tdark
Novelty: 1.45343096
p_int: 0.99975081
p_ni: 0.000249189
Data Source: BioPlex
Publication Statistics
PubMed Score  90.42

PubMed score by year
PubTator Score  41.74

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer