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Tbio
SEMA5A
Semaphorin-5A

Protein Summary
Description
Bifunctional axonal guidance cue regulated by sulfated proteoglycans; attractive effects result from interactions with heparan sulfate proteoglycans (HSPGs), while the inhibitory effects depend on interactions with chondroitin sulfate proteoglycans (CSPGs) (By similarity). Ligand for receptor PLXNB3. In glioma cells, SEMA5A stimulation of PLXNB3 results in the disassembly of F-actin stress fibers, disruption of focal adhesions and cellular collapse as well as inhibition of cell migration and invasion through ARHGDIA-mediated inactivation of RAC1. May promote angiogenesis by increasing endothelial cell proliferation and migration and inhibiting apoptosis. This gene belongs to the semaphorin gene family that encodes membrane proteins containing a semaphorin domain and several thrombospondin type-1 repeats. Members of this family are involved in axonal guidance during neural development. This gene has been implicated as an autism susceptibility gene.[provided by RefSeq, Jan 2010]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000382496
  • ENSP00000371936
  • ENSG00000112902

Symbol
  • SEMAF
  • semF
  • SEMAF
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
trait
1
biological process
0.99
protein domain
0.85
PubMedID
0.84
transcription factor perturbation
0.84


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 110.78   (req: < 5)
Gene RIFs: 27   (req: <= 3)
Antibodies: 297   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 110.78   (req: >= 5)
Gene RIFs: 27   (req: > 3)
Antibodies: 297   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 27
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (141)
PLXNB3
Tbio
Novelty:  0.02948198
Score:  0.961
Data Source:  Reactome,STRINGDB
PLXNA3
Tbio
Novelty:  0.02016528
Score:  0.941
Data Source:  STRINGDB
PLXNB1
Tbio
Novelty:  0.01073808
Score:  0.916
Data Source:  STRINGDB
SPON1
Tbio
Novelty:  0.01071398
Score:  0.915
Data Source:  STRINGDB
THSD7B
Tdark
Novelty:  0.34794254
Score:  0.909
Data Source:  STRINGDB
THBS1
Tchem
Novelty:  0.00073905
Score:  0.909
Data Source:  STRINGDB
THBS2
Tbio
Novelty:  0.00310724
Score:  0.908
Data Source:  STRINGDB
ADAMTSL1
Tbio
Novelty:  0.08853044
Score:  0.908
Data Source:  STRINGDB
THSD7A
Tbio
Novelty:  0.01515873
Score:  0.907
Data Source:  STRINGDB
ADAMTS12
Tbio
Family:  Enzyme
Novelty:  0.03184816
Score:  0.907
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (13)
Axon guidance (R-HSA-422475)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 12
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Axon guidance
Reactome
Defective B3GALTL causes Peters-plus syndrome (PpS)
Reactome
Developmental Biology
Reactome
Disease
Reactome
Diseases associated with O-glycosylation of proteins
Name
Explore in Pharos
Explore in Source
Axon guidance
Defective B3GALTL causes Peters-plus syndrome (PpS)
Developmental Biology
Disease
Diseases associated with O-glycosylation of proteins
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (31)
Find Similar Targets
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Disease Associations ()
No disease associations found
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
3
3
3
70.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
3
70.2
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
semaphorin 5A
VGNC:13583
461719
Macaque
semaphorin 5A
696019
Mouse
MGI:107556
20356
Rat
RGD:1308650
310207
Dog
semaphorin 5A
VGNC:45999
478622
Species
Name
OMA
EggNOG
Inparanoid
Chimp
semaphorin 5A
Macaque
semaphorin 5A
Mouse
Rat
Dog
semaphorin 5A
Publication Statistics
PubMed Score 110.78
PubMed score by year
PubTator Score 42.11
PubTator score by year
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Related Publications
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0 of 0
PMID
Year
Title