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Tbio
GRAP
GRB2-related adapter protein

Protein Summary
Description
Couples signals from receptor and cytoplasmic tyrosine kinases to the Ras signaling pathway. This gene encodes a member of the GRB2/Sem5/Drk family and functions as a cytoplasmic signaling protein which contains an SH2 domain flanked by two SH3 domains. The SH2 domain interacts with ligand-activated receptors for stem cell factor and erythropoietin, and facilitates the formation of a stable complex with the BCR-ABL oncoprotein. This protein also associates with the Ras guanine nucleotide exchange factor SOS1 (son of sevenless homolog 1) through its N-terminal SH3 domain. In general, it couples signals from receptor and cytoplasmic tyrosine kinases to the Ras signaling pathway. [provided by RefSeq, Jul 2012]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000284154
  • ENSP00000284154
  • ENSG00000154016
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
0.93
tissue sample
0.66
tissue
0.56
cell line
0.48
metabolite
0.45


Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 52.33   (req: < 5)
Gene RIFs: 7   (req: <= 3)
Antibodies: 152   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 52.33   (req: >= 5)
Gene RIFs: 7   (req: > 3)
Antibodies: 152   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
1,5 anhydroglucitol measurement
1
1
0
8.5
68.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
1,5 anhydroglucitol measurement
0
8.5
68.6
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
GRB2-related adaptor protein
702473
Mouse
MGI:1918770
71520
Rat
RGD:1306884
363616
Dog
GRB2-related adapter protein
489534
Cow
GRB2-related adaptor protein
534491
Species
Name
OMA
EggNOG
Inparanoid
Macaque
GRB2-related adaptor protein
Mouse
Rat
Dog
GRB2-related adapter protein
Cow
GRB2-related adaptor protein
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q13588-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (10)
Signal Transduction (R-HSA-162582)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Signal Transduction
Reactome
Signaling by Receptor Tyrosine Kinases
Reactome
Signaling by SCF-KIT
Name
Explore in Pharos
Explore in Source
Signal Transduction
Signaling by Receptor Tyrosine Kinases
Signaling by SCF-KIT
Gene Ontology Terms (5)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Traceable Author Statement (TAS)
ProtInc
Protein-Protein Interactions (89)
1 – 10 of 89
KIT
Tclin
Family:  Kinase
Novelty:  0.00011237
Score:  0.954
Data Source:  Reactome,STRINGDB
LCP2
Tbio
Novelty:  0.00512968
Score:  0.921
Data Source:  STRINGDB
GAB2
Tbio
Novelty:  0.00697372
Score:  0.887
Data Source:  STRINGDB
LAT
Tbio
Novelty:  0.00738419
Score:  0.825
Data Source:  STRINGDB
SOS1
Tchem
Novelty:  0.00285343
Score:  0.78
Data Source:  STRINGDB
SHC1
Tchem
Novelty:  0.00083615
Score:  0.771
Data Source:  STRINGDB
LIMD2
Tbio
Novelty:  0.08706366
Score:  0.768
Data Source:  STRINGDB
SOS2
Tbio
Novelty:  0.01607832
Score:  0.723
Data Source:  STRINGDB
GAB1
Tchem
Novelty:  0.02174353
Score:  0.68
Data Source:  STRINGDB
WAS
Tbio
Novelty:  0.00087362
Score:  0.656
Data Source:  STRINGDB
Publication Statistics
PubMed Score  52.33

PubMed score by year
PubTator Score  14.03

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer