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Tbio
GPR50
Melatonin-related receptor

Protein Summary
Description
Does not bind melatonin. This gene product belongs to the G-protein coupled receptor 1 family. Even though this protein shares similarity with the melatonin receptors, it does not bind melatonin, however, it inhibits melatonin receptor 1A function through heterodimerization. Polymorphic variants of this gene have been associated with bipolar affective disorder in women. [provided by RefSeq, Jan 2010]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000218316
  • ENSP00000218316
  • ENSG00000102195

Symbol
  • H9
  • Mel1c
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
cell type or tissue
0.62
disease perturbation
0.62
protein domain
0.58
gene perturbation
0.56
tissue
0.55


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 110.6   (req: < 5)
Gene RIFs: 16   (req: <= 3)
Antibodies: 294   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 110.6   (req: >= 5)
Gene RIFs: 16   (req: > 3)
Antibodies: 294   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (47)
MAS1
Tchem
Family:  GPCR
Novelty:  0.0089712
p_int:  0.999853803
p_ni:  0.000146188
p_wrong:  9e-9
Score:  0.233
Data Source:  BioPlex,STRINGDB
IPPK
Tbio
Family:  Enzyme
Novelty:  0.02169701
p_int:  0.998730107
p_ni:  0.001260167
p_wrong:  0.000009726
Data Source:  BioPlex
TMEM171
Tdark
Novelty:  2.00247773
p_int:  0.998385231
p_ni:  0.001614764
p_wrong:  5e-9
Score:  0.158
Data Source:  BioPlex,STRINGDB
HTR2C
Tclin
Family:  GPCR
Novelty:  0.00074287
p_int:  0.997544772
p_ni:  0.002304427
p_wrong:  0.000150801
Score:  0.204
Data Source:  BioPlex,STRINGDB
CLEC2D
Tbio
Novelty:  0.02501194
p_int:  0.995851574
p_ni:  0.003243463
p_wrong:  0.000904963
Data Source:  BioPlex
EVA1B
Tdark
Novelty:  2.1380272
p_int:  0.991564454
p_ni:  0.003762608
p_wrong:  0.004672938
Data Source:  BioPlex
LPAR1
Tchem
Family:  GPCR
Novelty:  0.00318056
p_int:  0.990956881
p_ni:  0.009043118
p_wrong:  1e-9
Score:  0.313
Data Source:  BioPlex,STRINGDB
GRPR
Tchem
Family:  GPCR
Novelty:  0.00282511
p_int:  0.974595421
p_ni:  0.024794196
p_wrong:  0.000610384
Score:  0.206
Data Source:  BioPlex,STRINGDB
P10321
Tbio
Novelty:  0.00698601
p_int:  0.966741659
p_ni:  0.033144131
p_wrong:  0.00011421
Data Source:  BioPlex
CD1A
Tbio
Novelty:  0.00090676
p_int:  0.945541618
p_ni:  0.054376768
p_wrong:  0.000081614
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
testosterone measurement
1
1
1
1.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
testosterone measurement
1
1.7
Find similar targets by:
IDG Resources
Genetic Construct
GPR50-Tango
image for GPR50-Tango
Details:
  • Vector:  addgene66361
  • Vector backbone:  pcDNA3.1(+)
  • Promoter:  CMV
  • Tag:  FLAG
Data:
  • GPR50-Tango
Order Genetic Construct from:
Orthologs (7)
1 – 5 of 7
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
G protein-coupled receptor 50
VGNC:12389
736267
Macaque
G protein-coupled receptor 50
703817
Mouse
MGI:1333877
14765
Rat
RGD:619863
117097
Dog
G protein-coupled receptor 50
VGNC:41437
492213
Species
Name
OMA
EggNOG
Inparanoid
Chimp
G protein-coupled receptor 50
Macaque
G protein-coupled receptor 50
Mouse
Rat
Dog
G protein-coupled receptor 50
Publication Statistics
PubMed Score 110.60
PubMed score by year
PubTator Score 86.84
PubTator score by year
Patents
Patents by year
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Related Publications
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PMID
Year
Title