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Tbio
IQGAP2
Ras GTPase-activating-like protein IQGAP2

Protein Summary
Description
Binds to activated CDC42 and RAC1 but does not seem to stimulate their GTPase activity. Associates with calmodulin. This gene encodes a member of the IQGAP family. The encoded protein contains three IQ domains, one calponin homology domain, one Ras-GAP domain and one WW domain. This protein interacts with components of the cytoskeleton, with cell adhesion molecules, and with several signaling molecules to regulate cell morphology and motility. It also acts as a tumor suppressor and has been found to play a role in regulating innate antiviral responses. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2017]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000274364
  • ENSP00000274364
  • ENSG00000145703
  • ENST00000396234
  • ENSP00000379535
  • ENST00000502745
  • ENSP00000426027
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
interacting protein
0.99
transcription factor perturbation
0.96
protein domain
0.92
transcription factor binding site profile
0.92
molecular function
0.91


Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 36.7   (req: < 5)
Gene RIFs: 21   (req: <= 3)
Antibodies: 182   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 36.7   (req: >= 5)
Gene RIFs: 21   (req: > 3)
Antibodies: 182   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 12
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (17)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean platelet volume
5
11
14
99.8
platelet count
3
4
4
6.1
97.9
reticulocyte count
4
5
9
96.9
reticulocyte measurement
2
3
6
94.7
proteinase-activated receptor 1 measurement
1
2
2
82.9
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean platelet volume
14
99.8
platelet count
4
6.1
97.9
reticulocyte count
9
96.9
reticulocyte measurement
6
94.7
proteinase-activated receptor 1 measurement
2
82.9
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
IQ motif containing GTPase activating protein 2
VGNC:4048
461801
Macaque
IQ motif containing GTPase activating protein 2
712026
Mouse
MGI:2449975
544963
Rat
RGD:2321734
100360623
Dog
IQ motif containing GTPase activating protein 2
VGNC:42082
479177
Species
Name
OMA
EggNOG
Inparanoid
Chimp
IQ motif containing GTPase activating protein 2
Macaque
IQ motif containing GTPase activating protein 2
Mouse
Rat
Dog
IQ motif containing GTPase activating protein 2
Protein Structure (3 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q13576-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 3 of 3
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (32)
Immune System (R-HSA-168256)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 7
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Immune System
Reactome
Innate Immune System
Reactome
Neutrophil degranulation
Reactome
RHO GTPase Effectors
Reactome
RHO GTPases activate IQGAPs
Name
Explore in Pharos
Explore in Source
Immune System
Innate Immune System
Neutrophil degranulation
RHO GTPase Effectors
RHO GTPases activate IQGAPs
Gene Ontology Terms (23)
Items per page:
10
1 – 8 of 8
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Traceable Author Statement (TAS)
ProtInc
Traceable Author Statement (TAS)
ProtInc
Protein-Protein Interactions (81)
1 – 10 of 81
MYL12B
Tbio
Novelty:  0.00999083
p_int:  0.995982391
p_ni:  0.004017609
Score:  0.276
Data Source:  BioPlex,STRINGDB
ABTB2
Tdark
Novelty:  0.45729157
p_int:  0.994555786
p_ni:  0.005444214
Data Source:  BioPlex
CALML3
Tbio
Novelty:  0.0336689
p_int:  0.957572452
p_ni:  0.042427548
Score:  0.213
Data Source:  BioPlex,STRINGDB
SUCLA2
Tchem
Family:  Enzyme
Novelty:  0.02029861
p_int:  0.938286298
p_ni:  0.061713702
Score:  0.242
Data Source:  BioPlex,STRINGDB
SDF4
Tbio
Novelty:  0.00105893
p_int:  0.922887381
p_ni:  0.077112619
Score:  0.222
Data Source:  BioPlex,STRINGDB
MAGEA1
Tbio
Novelty:  0.00506874
p_int:  0.855463209
p_ni:  0.144536791
Score:  0.189
Data Source:  BioPlex,STRINGDB
KHDC1
Tbio
Novelty:  0.13778027
p_int:  0.806089424
p_ni:  0.193910576
Data Source:  BioPlex
CDC42
Tchem
Family:  Enzyme
Novelty:  0.00032619
Score:  0.988
Data Source:  Reactome,STRINGDB
RAC1
Tbio
Family:  Enzyme
Novelty:  0.00365325
Score:  0.969
Data Source:  Reactome,STRINGDB
CDH1
Tbio
Novelty:  0.00010629
Score:  0.96
Data Source:  STRINGDB
Publication Statistics
PubMed Score  36.70

PubMed score by year
PubTator Score  28.63

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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