Tchem DGKZ Diacylglycerol kinase zeta

Protein Summary

Description

Displays a strong preference for 1,2-diacylglycerols over 1,3-diacylglycerols, but lacks substrate specificity among molecular species of long chain diacylglycerols. Isoform 2 but not isoform 1 regulates RASGRP1 activity (PubMed:11257115). Positively regulates insulin-induced translocation of SLC2A4 to the cell membrane in adipocytes (By similarity). Activates PIP5K1A activity via generation of phosphatidic acid (PubMed:15157668). The protein encoded by this gene belongs to the eukaryotic diacylglycerol kinase family. It may attenuate protein kinase C activity by regulating diacylglycerol levels in intracellular signaling cascade and signal transduction. Alternative splicing occurs at this locus and multiple transcript variants encoding distinct isoforms have been identified. [provided by RefSeq, Nov 2010]

Uniprot Accession IDs

• Q13574
• B7Z2M9
• B7Z6M3
• E9PPW4
• F6UCU9
• G3V0F6
• J3KNJ6
• O00542
• Q6ZVG7
• Q8IVW9
• DAG kinase zeta

Gene Name

• DGKZ

Ensembl ID

• ENST00000318201
• ENSP00000320340
• ENSG00000149091
• ENST00000343674
• ENSP00000343065
• ENST00000421244
• ENSP00000391021
• ENST00000454345
• ENSP00000412178
• ENST00000456247
• ENSP00000395684
• ENST00000527911
• ENSP00000436291
• ENST00000532868
• ENSP00000436273

Symbol

• DAGK6
• DAGK5
• DAGK6
• DGK-ZETA
• hDGKzeta

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
molecular function	0.96
transcription factor	0.86
protein domain	0.85
transcription factor perturbation	0.74
metabolite	0.72

Protein Classes

PANTHER Classes

Protein / Transferase / Kinase / Diacylglycerol Kinase Zeta

DTO Classes

Protein / Enzyme / Transferase / Diacylglycerol Kinase Zeta

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 105.38   (req: < 5)

Gene RIFs: 37   (req: <= 3)

Antibodies: 204   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 105.38   (req: >= 5)

Gene RIFs: 37   (req: > 3)

Antibodies: 204   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 18

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 4

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0