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Tbio
SNW1
SNW domain-containing protein 1

Protein Summary
Description
Involved in pre-mRNA splicing as component of the spliceosome (PubMed:11991638, PubMed:28502770, PubMed:28076346). Is required in the specific splicing of CDKN1A pre-mRNA; the function probably involves the recruitment of U2AF2 to the mRNA. Is proposed to recruit PPIL1 to the spliceosome. May be involved in cyclin-D1/CCND1 mRNA stability through the SNARP complex which associates with both the 3'end of the CCND1 gene and its mRNA. Involved in transcriptional regulation. Modulates TGF-beta-mediated transcription via association with SMAD proteins, MYOD1-mediated transcription via association with PABPN1, RB1-mediated transcriptional repression, and retinoid-X receptor (RXR)- and vitamin D receptor (VDR)-dependent gene transcription in a cell line-specific manner probably involving coactivators NCOA1 and GRIP1. Is involved in NOTCH1-mediated transcriptional activation. Binds to multimerized forms of Notch intracellular domain (NICD) and is proposed to recruit transcriptional coactivators ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000261531
  • ENSP00000261531
  • ENSG00000100603

Symbol
  • SKIIP
  • SKIP
  • Bx42
  • SKIP
  • FUN20
  • Prp45
  • SKIIP
  • SKIP1
  • PRPF45
  • NCOA-62
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0.99
disease perturbation
0.98
hub protein
0.96
kinase perturbation
0.93
interacting protein
0.86


Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 83.04   (req: < 5)
Gene RIFs: 26   (req: <= 3)
Antibodies: 119   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 83.04   (req: >= 5)
Gene RIFs: 26   (req: > 3)
Antibodies: 119   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 31
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
red blood cell distribution width
3
3
3
87.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
red blood cell distribution width
3
87.3
Orthologs (16)
1 – 5 of 16
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
SNW domain containing 1
VGNC:3313
453073
Mouse
MGI:1913604
66354
Rat
RGD:1561926
500695
Dog
SNW domain containing 1
480405
Horse
SNW domain containing 1
VGNC:23408
100059578
Species
Name
OMA
EggNOG
Inparanoid
Chimp
SNW domain containing 1
Mouse
Rat
Dog
SNW domain containing 1
Horse
SNW domain containing 1
Protein Structure (4 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q13573-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 4 of 4
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (44)
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants (R-HSA-2894862)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 34
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants
Reactome
Constitutive Signaling by NOTCH1 PEST Domain Mutants
Reactome
Developmental Biology
Reactome
Disease
Reactome
Diseases of signal transduction
Name
Explore in Pharos
Explore in Source
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants
Constitutive Signaling by NOTCH1 PEST Domain Mutants
Developmental Biology
Disease
Diseases of signal transduction
Gene Ontology Terms (39)
Items per page:
10
1 – 10 of 10
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
CAFA
Inferred from Physical Interaction (IPI)
CAFA
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from High Throughput Direct Assay (HDA)
UniProtKB
Protein-Protein Interactions (457)
1 – 10 of 457
MUC5B
Tbio
Novelty:  0.000832
p_int:  0.999994209
p_ni:  0.000005791
Data Source:  BioPlex
CWF19L2
Tdark
Novelty:  0.80210985
p_int:  0.999985144
p_ni:  0.000014856
Score:  0.747
Data Source:  BioPlex,STRINGDB
SPRR3
Tbio
Novelty:  0.0241484
p_int:  0.999885147
p_ni:  0.000040049
p_wrong:  0.000074804
Data Source:  BioPlex
ZNF830
Tdark
Novelty:  0.38957008
p_int:  0.99985443
p_ni:  0.000143876
p_wrong:  0.000001693
Score:  0.729
Data Source:  BioPlex,STRINGDB
AQR
Tbio
Novelty:  0.00434312
p_int:  0.999840677
p_ni:  0.000159323
Score:  0.997
Data Source:  BioPlex,STRINGDB
GPATCH1
Tdark
Novelty:  0.93318176
p_int:  0.999835346
p_ni:  0.000164654
Score:  0.2
Data Source:  BioPlex,STRINGDB
CRNKL1
Tbio
Novelty:  0.10274174
p_int:  0.999669548
p_ni:  0.000330452
Score:  0.999
Data Source:  BioPlex,STRINGDB
DHX35
Tdark
Family:  Enzyme
Novelty:  0.26052594
p_int:  0.999661485
p_ni:  0.000338515
Score:  0.866
Data Source:  BioPlex,STRINGDB
IGHA2
Tbio
p_int:  0.999580315
p_ni:  0.000419552
p_wrong:  1.34e-7
Data Source:  BioPlex
CRNN
Tbio
Novelty:  0.01648731
p_int:  0.999206702
p_ni:  0.000793298
Data Source:  BioPlex
Publication Statistics
PubMed Score  83.04

PubMed score by year
PubTator Score  680.87

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer