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Tbio
ITPK1
Inositol-tetrakisphosphate 1-kinase

Protein Summary
Description
Kinase that can phosphorylate various inositol polyphosphate such as Ins(3,4,5,6)P4 or Ins(1,3,4)P3. Phosphorylates Ins(3,4,5,6)P4 at position 1 to form Ins(1,3,4,5,6)P5. This reaction is thought to have regulatory importance, since Ins(3,4,5,6)P4 is an inhibitor of plasma membrane Ca(2+)-activated Cl(-) channels, while Ins(1,3,4,5,6)P5 is not. Also phosphorylates Ins(1,3,4)P3 on O-5 and O-6 to form Ins(1,3,4,6)P4, an essential molecule in the hexakisphosphate (InsP6) pathway. Also acts as an inositol polyphosphate phosphatase that dephosphorylate Ins(1,3,4,5)P4 and Ins(1,3,4,6)P4 to Ins(1,3,4)P3, and Ins(1,3,4,5,6)P5 to Ins(3,4,5,6)P4. May also act as an isomerase that interconverts the inositol tetrakisphosphate isomers Ins(1,3,4,5)P4 and Ins(1,3,4,6)P4 in the presence of ADP and magnesium. Probably acts as the rate-limiting enzyme of the InsP6 pathway. Modifies TNF-alpha-induced apoptosis by interfering with the activation of TNFRSF1A-associated death domain (PubMed:11909533, PubMed ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000267615
  • ENSP00000267615
  • ENSG00000100605
  • ENST00000354313
  • ENSP00000346272
  • ENST00000556603
  • ENSP00000451091
  • ENST00000614271
  • ENSP00000483767
  • ENSG00000274958
  • ENST00000617836
  • ENSP00000480918
  • ENST00000626153
  • ENSP00000486991

Symbol
  • ITRPK1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
1
disease perturbation
0.99
trait
0.99
interacting protein
0.94
PubMedID
0.86


Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
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GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 37.56   (req: < 5)
Gene RIFs: 7   (req: <= 3)
Antibodies: 268   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 37.56   (req: >= 5)
Gene RIFs: 7   (req: > 3)
Antibodies: 268   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 20
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (18)
Items per page:
1 – 5 of 18
GWAS Trait
EFO ID
ENSG ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
platelet count
2
2
1
3.6
86.9
platelet count
2
2
1
3.6
86.9
platelet crit
2
1
2
81.5
platelet crit
2
1
2
81.5
body height
1
1
1
54.4
Items per page:
1 – 5 of 18
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
platelet count
1
3.6
86.9
platelet count
1
3.6
86.9
platelet crit
2
81.5
platelet crit
2
81.5
body height
1
54.4
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
inositol-tetrakisphosphate 1-kinase
453121
Macaque
inositol-tetrakisphosphate 1-kinase
698756
Mouse
MGI:2446159
217837
Rat
RGD:1595691
500709
Dog
inositol-tetrakisphosphate 1-kinase
VGNC:42153
490591
Species
Name
OMA
EggNOG
Inparanoid
Chimp
inositol-tetrakisphosphate 1-kinase
Macaque
inositol-tetrakisphosphate 1-kinase
Mouse
Rat
Dog
inositol-tetrakisphosphate 1-kinase
Protein Structure (3 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q13572-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 3 of 3
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (14)
Factors involved in megakaryocyte development and platelet production (R-HSA-983231)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 6
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Factors involved in megakaryocyte development and platelet production
Reactome
Hemostasis
Reactome
Inositol phosphate metabolism
Reactome
Metabolism
Reactome
Synthesis of IP3 and IP4 in the cytosol
Name
Explore in Pharos
Explore in Source
Factors involved in megakaryocyte development and platelet production
Hemostasis
Inositol phosphate metabolism
Metabolism
Synthesis of IP3 and IP4 in the cytosol
Gene Ontology Terms (23)
Items per page:
10
1 – 10 of 13
GO Term
Evidence
Assigned by
Inferred from Experiment (EXP)
Reactome
Inferred from Experiment (EXP)
Reactome
Inferred from Experiment (EXP)
Reactome
Inferred from Mutant Phenotype (IMP)
UniProtKB
Traceable Author Statement (TAS)
ProtInc
Traceable Author Statement (TAS)
Reactome
Traceable Author Statement (TAS)
Reactome
Traceable Author Statement (TAS)
Reactome
Traceable Author Statement (TAS)
Reactome
Traceable Author Statement (TAS)
Reactome
Protein-Protein Interactions (70)
1 – 10 of 70
CRYZL1
Tbio
Family:  Enzyme
Novelty:  0.04435286
p_int:  0.99971934
p_ni:  0.000280646
p_wrong:  1.5e-8
Score:  0.455
Data Source:  BioPlex,STRINGDB
SCN2B
Tbio
Family:  IC
Novelty:  0.03773629
p_int:  0.999467125
p_ni:  0.000473064
p_wrong:  0.000059811
Score:  0.181
Data Source:  BioPlex,STRINGDB
TRAC
Tdark
p_int:  0.999150796
p_ni:  0.000750081
p_wrong:  0.000099123
Data Source:  BioPlex
IPPK
Tbio
Family:  Enzyme
Novelty:  0.02169701
Score:  0.98
Data Source:  STRINGDB
IPMK
Tbio
Family:  Kinase
Novelty:  0.01837813
Score:  0.977
Data Source:  STRINGDB
IP6K1
Tbio
Family:  Kinase
Novelty:  0.03418032
Score:  0.959
Data Source:  STRINGDB
PPIP5K1
Tbio
Family:  Enzyme
Novelty:  0.01175655
Score:  0.954
Data Source:  STRINGDB
ITPKA
Tchem
Family:  Kinase
Novelty:  0.02901348
Score:  0.942
Data Source:  STRINGDB
ITPKB
Tchem
Family:  Kinase
Novelty:  0.02397335
Score:  0.942
Data Source:  STRINGDB
IP6K2
Tbio
Family:  Kinase
Novelty:  0.05004446
Score:  0.941
Data Source:  STRINGDB
Publication Statistics
PubMed Score  37.56

PubMed score by year
PubTator Score  14.68

PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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