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Tbio
LAPTM5
Lysosomal-associated transmembrane protein 5

Protein Summary
Description
May have a special functional role during embryogenesis and in adult hematopoietic cells. This gene encodes a transmembrane receptor that is associated with lysosomes. The encoded protein, also known as E3 protein, may play a role in hematopoiesis. [provided by RefSeq, Feb 2009]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000294507
  • ENSP00000294507
  • ENSG00000162511

Symbol
  • KIAA0085
  • CLAST6
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
0.99
PubMedID
0.98
transcription factor perturbation
0.97
disease perturbation
0.87
cellular component
0.75


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 18.58   (req: < 5)
Gene RIFs: 9   (req: <= 3)
Antibodies: 90   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 18.58   (req: >= 5)
Gene RIFs: 9   (req: > 3)
Antibodies: 90   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 1
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Protein-Protein Interactions (118)
1 – 10 of 118
SPI1
Tbio
Family:  TF
Novelty:  0.00064309
Score:  0.912
Data Source:  STRINGDB
CD53
Tbio
Novelty:  0.01722633
Score:  0.91
Data Source:  STRINGDB
ITGB2
Tclin
Novelty:  0.00185859
Score:  0.88
Data Source:  STRINGDB
TYROBP
Tbio
Family:  Enzyme
Novelty:  0.00410031
Score:  0.861
Data Source:  STRINGDB
CORO1A
Tbio
Novelty:  0.00898925
Score:  0.853
Data Source:  STRINGDB
LAPTM4A
Tbio
Novelty:  0.00467804
Score:  0.834
Data Source:  STRINGDB
LAPTM4B
Tbio
Novelty:  0.01162533
Score:  0.831
Data Source:  STRINGDB
HCLS1
Tbio
Novelty:  0.08304056
Score:  0.827
Data Source:  STRINGDB
CTSS
Tchem
Family:  Enzyme
Novelty:  0.00786042
Score:  0.805
Data Source:  STRINGDB
PLEK
Tbio
Novelty:  0.00074263
Score:  0.803
Data Source:  STRINGDB
Gene Ontology Terms (5)
Items per page:
10
1 – 4 of 4
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Traceable Author Statement (TAS)
ProtInc
Traceable Author Statement (TAS)
ProtInc
Inferred from Electronic Annotation (IEA)
UniProtKB-SubCell
GWAS Traits (7)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
myeloid white cell count
1
1
1
38.2
neutrophil count
2
1
2
34.8
leukocyte count
1
1
1
32.8
platelet crit
2
1
2
31.2
platelet count
2
1
2
26.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
myeloid white cell count
1
38.2
neutrophil count
2
34.8
leukocyte count
1
32.8
platelet crit
2
31.2
platelet count
2
26.5
Find similar targets by:
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
lysosomal protein transmembrane 5
VGNC:10703
456693
Macaque
lysosomal protein transmembrane 5
704041
Mouse
MGI:108046
16792
Rat
RGD:621838
89783
Dog
lysosomal protein transmembrane 5
VGNC:42584
487324
Species
Name
OMA
EggNOG
Inparanoid
Chimp
lysosomal protein transmembrane 5
Macaque
lysosomal protein transmembrane 5
Mouse
Rat
Dog
lysosomal protein transmembrane 5
Publication Statistics
PubMed Score 18.58
PubMed score by year
PubTator Score 12.12
PubTator score by year